Large placental chorioangioma

Chorioangioma of the placenta is a benign vascular tumor arising from the primitive chorionic mesenchyme whose etiology is unknown. It occurs in approximately 1% of all pregnancies and has generally no clinical significance (1). In the rare cases in which the size of this tumor is large (diameter .4 cm) various and significant maternal and fetal complications, with a considerable increase of fetal mortality (30–40%), are reported (1, 2, 3): in these cases the presence of early maternal serum markers would be of great clinical interest.