The blood saving potential of vortex versus roller pump with and without aprotinin

To evaluate the potential of centrifugal blood pumps for saving blood, 120 patients scheduled for elective coronary artery bypass grafting were entered into a prospective randomized trial. A standard roller pump (group I) was compared with a centrifugal blood pump (group II) and roller pump plus aprotinin (group III). There was no significant difference between groups I and I I with respect to free haemoglobin, lactic dehydrogenase, serum bilirubin, platelet surface glycoprotein IIb-IIIa and granule membrane protein 140, chest-tube drainage, use of blood products, length of stay in intensive care, time on ventilator and postoperative mortality. Aprotinin reduced chest-tube drainage and use of blood products significantly. Three cases of graft occlusions were noted in group III. Centrifugal blood pumps offer no advantage in routine heart surgery over conventional roller pumps. Aprotinin reduces blood loss, but does not influence GP IIb-IIIa and GMP 140 expression on blood platelets.

[1]  T. Dickinson,et al.  A comparison of the benefits of roller pump versus constrained vortex pump in adult open-heart operations utilizing outcomes research. , 1994, The journal of extra-corporeal technology.

[2]  H. Teufelsbauer,et al.  Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood. , 1994, The Journal of thoracic and cardiovascular surgery.

[3]  P. Nurden,et al.  Markers of platelet activation in coronary heart disease patients , 1994, European journal of clinical investigation.

[4]  T. Sundt,et al.  Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest. , 1993, The Annals of thoracic surgery.

[5]  F. Loop,et al.  Aprotinin therapy for reoperative myocardial revascularization: a placebo-controlled study. , 1992, The Annals of thoracic surgery.

[6]  T. Masuzawa,et al.  Influence of an impeller centrifugal pump on blood components in chronic animal experiments. , 1992, ASAIO journal.

[7]  W. Butt,et al.  Pump-induced haemolysis: is the constrained vortex pump better or worse than the roller pump? , 1992 .

[8]  C. Yakut,et al.  Cardiopulmonary Bypass Using Centrifugal Pump , 1992 .

[9]  J. Driessen,et al.  Comparison of the standard roller pump and a pulsatile centrifugal pump for extracorporeal circulation during routine coronary artery bypass grafting , 1991, Perfusion.

[10]  J. Mathew,et al.  Modulation of platelet surface adhesion receptors during cardiopulmonary bypass. , 1991, Anesthesiology.

[11]  R. Hillman,et al.  Platelet activation and aggregation during cardiopulmonary bypass. , 1991, Anesthesiology.

[12]  G. Hafner,et al.  Routine extracorporeal circulation with a centrifugal or roller pump. , 1991, ASAIO transactions.

[13]  W. Prellwitz,et al.  In-vitro assessment of centrifugal pumps for ventricular assist. , 1990, Artificial organs.

[14]  W. van Oeveren,et al.  Aprotinin protects platelets against the initial effect of cardiopulmonary bypass. , 1990, The Journal of thoracic and cardiovascular surgery.

[15]  R. Guyton,et al.  Hematologic derangements of cardiopulmonary bypass: a comparison of two perfusion systems. , 1990, The journal of extra-corporeal technology.

[16]  K. M. Taylor,et al.  EFFECT OF APROTININ ON NEED FOR BLOOD TRANSFUSION AFTER REPEAT OPEN-HEART SURGERY , 1987, The Lancet.

[17]  J. Crowley,et al.  In Vitro Comparison of the Blood Handling by the Constrained Vortex and Twin Roller Blood Pumps , 1987, The Journal of ExtraCorporeal Technology.

[18]  E. Blackstone,et al.  Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins. , 1981, The New England journal of medicine.

[19]  M F Lynch,et al.  Centrifugal blood pumping for open heart surgery. , 1978, Minnesota medicine.

[20]  H. Huwer,et al.  Is there a phase of hypercoagulability when aprotinin is used in cardiac surgery? , 1994, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[21]  R. Prêtre,et al.  Influence of aprotinin on early graft thrombosis in patients undergoing myocardial revascularization. , 1994, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[22]  G. Hafner,et al.  Reoperation and the centrifugal pump? , 1992, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.