Improvement of Human Multilineage Hematopoietic Engraftment by Cytokine Knock-in Replacement in Human‐Hemato‐Lymphoid System Mice

[1]  R. Flavell,et al.  Human hemato-lymphoid system mice: current use and future potential for medicine. , 2013, Annual review of immunology.

[2]  P. Bourgine,et al.  Engineering of a functional bone organ through endochondral ossification , 2013, Proceedings of the National Academy of Sciences.

[3]  D. Greiner,et al.  Humanized mice for immune system investigation: progress, promise and challenges , 2012, Nature Reviews Immunology.

[4]  Raymond Dunn,et al.  Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF. , 2012, Blood.

[5]  O. Ohara,et al.  Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. , 2012, Blood.

[6]  Elisa Laurenti,et al.  Hematopoiesis: a human perspective. , 2012, Cell stem cell.

[7]  Yong-Guang Yang,et al.  Macrophages prevent human red blood cell reconstitution in immunodeficient mice. , 2011, Blood.

[8]  M. Merad,et al.  Studying the mononuclear phagocyte system in the molecular age , 2011, Nature Reviews Immunology.

[9]  A. Murphy,et al.  Efficient differentiation and function of human macrophages in humanized CSF-1 mice. , 2011, Blood.

[10]  J. D. Di Santo,et al.  Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo , 2011, Proceedings of the National Academy of Sciences.

[11]  R. Flavell,et al.  Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice , 2011, Proceedings of the National Academy of Sciences.

[12]  R. Flavell,et al.  Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. , 2011, Trends in immunology.

[13]  A. Murphy,et al.  Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung , 2011, Proceedings of the National Academy of Sciences.

[14]  A. Murphy,et al.  Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo , 2010, Proceedings of the National Academy of Sciences.

[15]  Ryan M. O’Connell,et al.  Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7) to Human Immune System (HIS) Mice Expands T Lymphocyte Populations , 2010, PloS one.

[16]  Jianzhu Chen,et al.  Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice , 2009, Proceedings of the National Academy of Sciences.

[17]  B. Blom,et al.  IL-7 Enhances Thymic Human T Cell Development in “Human Immune System” Rag2−/−IL-2Rγc−/− Mice without Affecting Peripheral T Cell Homeostasis1 , 2009, The Journal of Immunology.

[18]  F. Geissmann,et al.  Blood monocytes: development, heterogeneity, and relationship with dendritic cells. , 2009, Annual review of immunology.

[19]  J. D. Di Santo,et al.  IL-15 trans-presentation promotes human NK cell development and differentiation in vivo , 2009, The Journal of experimental medicine.

[20]  T. Suda,et al.  Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. , 2007, Cell stem cell.

[21]  Lina A. Thoren,et al.  Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. , 2007, Cell stem cell.

[22]  J. Dick,et al.  Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells , 2007, Nature Immunology.

[23]  M. Manz,et al.  Macrophage tolerance: CD47–SIRP-α–mediated signals matter , 2007, Nature Immunology.

[24]  M. Manz.  Human-hemato-lymphoid-system mice: opportunities and challenges. , 2007, Immunity.

[25]  Dale L. Greiner,et al.  Humanized mice in translational biomedical research , 2007, Nature Reviews Immunology.

[26]  H. Spits,et al.  Experimental Models to Study Development and Function of the Human Immune System In Vivo , 2006, The Journal of Immunology.

[27]  K. Akashi,et al.  Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice , 2005 .

[28]  Markus G. Manz,et al.  Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice , 2004, Science.

[29]  C. Hughes,et al.  Of Mice and Not Men: Differences between Mouse and Human Immunology , 2004, The Journal of Immunology.

[30]  C. Eaves,et al.  NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration , 2004, Leukemia.

[31]  Lawrence S. Chan,et al.  Human Immune System , 2003 .

[32]  Irving L Weissman,et al.  Biology of hematopoietic stem cells and progenitors: implications for clinical application. , 2003, Annual review of immunology.

[33]  N. Fox,et al.  Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. , 2003, Blood.

[34]  A. F. Stewart,et al.  High-throughput engineering of the mouse genome coupled with high-resolution expression analysis , 2003, Nature Biotechnology.

[35]  Mamoru Ito,et al.  NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. , 2002, Blood.

[36]  N. Fox,et al.  Thrombopoietin expands hematopoietic stem cells after transplantation. , 2002, The Journal of clinical investigation.

[37]  O. Kollet,et al.  NOD/LtSz-Rag1null Mice: An Immunodeficient and Radioresistant Model for Engraftment of Human Hematolymphoid Cells, HIV Infection, and Adoptive Transfer of NOD Mouse Diabetogenic T Cells1 , 2000, The Journal of Immunology.

[38]  F. Moreau-Gaudry,et al.  A Novel Immunodeficient Mouse Model-RAG2 gamma Cytokine Receptor Chain Double Mutants-Requiring Exogenous Cytokine Administration for Human Hematopoietic Stem Cell Engraftment Common , 1999 .

[39]  A. Dunn,et al.  Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[40]  G. Dranoff,et al.  Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. , 1994, Science.

[41]  J. Dick,et al.  Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice. , 1992, Science.

[42]  J. Dick,et al.  Engraftment of immune-deficient mice with human hematopoietic stem cells. , 1988, Science.

[43]  I. Weissman,et al.  The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. , 1988, Science.

[44]  Donald E. Mosier,et al.  Transfer of a functional human immune system to mice with severe combined immunodeficiency , 1988, Nature.