Collagen disruption as a marker for basal cell carcinoma in presurgical margin detection

Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States. Surgery is the most common treatment for these tumors, but pre‐operative identification of surgical margins is challenging. The objective in this study was to determine whether optical polarization imaging (OPI) could be used prior to surgery to detect the extent of subclinical tumor spread by monitoring disruption in collagen.

[1]  Anna N Yaroslavsky,et al.  Multimodal imaging for nonmelanoma skin cancer margin delineation , 2017, Lasers in surgery and medicine.

[2]  Collin M. Stultz,et al.  Collagen--a necessary accomplice in the metastatic process. , 2007, Cancer genomics & proteomics.

[3]  Elena Salomatina,et al.  Optical properties of normal and cancerous human skin in the visible and near-infrared spectral range. , 2006, Journal of biomedical optics.

[4]  Ilya Yaroslavsky,et al.  Polarization enhanced wide‐field imaging for evaluating dermal changes caused by non‐ablative fractional laser treatment , 2016, Lasers in surgery and medicine.

[5]  A. Koloydenko,et al.  Diagnosis of tumors during tissue-conserving surgery with integrated autofluorescence and Raman scattering microscopy , 2013, Proceedings of the National Academy of Sciences.

[6]  Murad Alam,et al.  Needs assessment for Mohs micrographic surgery. , 2012, Dermatologic clinics.

[7]  Anna N. Yaroslavsky,et al.  Wavelength optimized cross-polarized wide-field imaging for noninvasive and rapid evaluation of dermal structures. , 2015, Journal of biophotonics.

[8]  G. Jemec,et al.  Optical coherence tomography in the diagnosis of basal cell carcinoma , 2014, Archives of Dermatological Research.

[9]  B. Rao,et al.  Uses of non‐invasive imaging in the diagnosis of skin cancer: an overview of the currently available modalities , 2013, International journal of dermatology.

[10]  M. Makary,et al.  Outlier Practice Patterns in Mohs Micrographic Surgery: Defining the Problem and a Proposed Solution , 2017, JAMA dermatology.

[11]  G. Argenziano,et al.  Evaluating ex vivo fluorescence confocal microscopy images of basal cell carcinomas in Mohs excised tissue , 2014, The British journal of dermatology.

[12]  J. Strasswimmer,et al.  Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high‐powered CO2 laser , 2014, Lasers in surgery and medicine.

[13]  W. Stetler-Stevenson.  Type IV collagenases in tumor invasion and metastasis , 1990, Cancer and Metastasis Reviews.

[14]  A. Kauvar,et al.  Consensus for Nonmelanoma Skin Cancer Treatment, Part II: Squamous Cell Carcinoma, Including a Cost Analysis of Treatment Methods , 2015, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[15]  M. Rajadhyaksha,et al.  Confocal imaging of carbon dioxide laser‐ablated basal cell carcinomas: An ex‐vivo study on the uptake of contrast agent and ablation parameters , 2016, Lasers in surgery and medicine.

[16]  Takeshi Yasui,et al.  In vivo observation of age-related structural changes of dermal collagen in human facial skin using collagen-sensitive second harmonic generation microscope equipped with 1250-nm mode-locked Cr:Forsterite laser , 2012, Journal of biomedical optics.

[17]  A. Kauvar,et al.  Consensus for Nonmelanoma Skin Cancer Treatment: Basal Cell Carcinoma, Including a Cost Analysis of Treatment Methods , 2015, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[18]  S. Feldman,et al.  Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the U.S. Population, 2012. , 2015, JAMA dermatology.

[19]  Anna N Yaroslavsky,et al.  Optical mapping of nonmelanoma skin Cancers—A pilot clinical study , 2017, Lasers in surgery and medicine.

[20]  A. Marghoob,et al.  Skin Cancer Diagnosis With Reflectance Confocal Microscopy: Reproducibility of Feature Recognition and Accuracy of Diagnosis. , 2015, JAMA dermatology.

[21]  Anna N Yaroslavsky,et al.  Demarcation of nonmelanoma skin cancer margins in thick excisions using multispectral polarized light imaging. , 2003, The Journal of investigative dermatology.