Molecular rotors and motors: recent advances and future challenges.

At the "Molecular Rotors and Motors" symposium of the Spring 2009 ACS National Meeting in Salt Lake City (March 22-26), a diverse mix of talks addressed many current issues in the field. Speakers described topics that varied from single-molecule rotors and nanomachines to exquisite synthetic approaches toward building functional materials and mathematical and computational methods aimed at uncovering design opportunities and highlighting the fundamental limitations of molecular motors. While the realization of building useful nanomachines remains far off, a general consensus abounded that investigating biological systems and understanding the implications of the laws of thermodynamics and quantum mechanics for the behavior of nanostructures will help drive important advances in the quest for molecular machinery. Molecular rotors were demonstrated to have practical applications as probes for microviscosity, and many speakers presented experimental studies that indicated that highly directed translation and rotation of individual molecules, as well as interacting dipolar arrays, are just around the corner. While this Nano Focus is not intended to be a comprehensive review of the subject, it will focus on several key advances that were presented at the ACS meeting and highlight future challenges for the field of molecular rotors and motors.

[1]  Auke Meetsma,et al.  MHz unidirectional rotation of molecular rotary motors. , 2008, Journal of the American Chemical Society.

[2]  T R Kelly,et al.  Progress toward a rationally designed molecular motor. , 2001, Accounts of chemical research.

[3]  James M Tour,et al.  Synthesis of a nanocar with an angled chassis. Toward circling movement. , 2008, Organic letters.

[4]  Richard A. Silva,et al.  Unidirectional rotary motion in a molecular system , 1999, Nature.

[5]  Josef Michl,et al.  A MOLECULAR TINKERTOY CONSTRUCTION KIT : COMPUTER SIMULATION OF MOLECULAR PROPELLERS , 1997 .

[6]  M. Ratner,et al.  Molecular Dipole Chains: Excitations and Dissipation , 1998 .

[7]  James M Tour,et al.  Surface-rolling molecules. , 2006, Journal of the American Chemical Society.

[8]  Josef Michl,et al.  Altitudinal Surface-Mounted Molecular Rotors , 2006 .

[9]  P. Weiss,et al.  Tuning interactions between ligands in self-assembled double-decker phthalocyanine arrays. , 2006, Journal of the American Chemical Society.

[10]  Mark A Haidekker,et al.  Molecular rotors--fluorescent biosensors for viscosity and flow. , 2007, Organic & biomolecular chemistry.

[11]  Robert D. Horansky,et al.  Dielectric response of a dipolar molecular rotor crystal , 2005 .

[12]  T. Ross Kelly,et al.  In Search of Molecular Ratchets , 1997 .

[13]  J. Bochinski,et al.  Dynamics within alkylsiloxane self-assembled monolayers studied by sensitive dielectric spectroscopy. , 2008, ACS nano.

[14]  Dominik Horinek,et al.  Surface-mounted altitudinal molecular rotors in alternating electric field: single-molecule parametric oscillator molecular dynamics. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[15]  James M Tour,et al.  Molecular Dynamics of Surface-Moving Thermally Driven Nanocars. , 2008, Journal of chemical theory and computation.

[16]  Heather L. Tierney,et al.  A quantitative single-molecule study of thioether molecular rotors. , 2008, ACS nano.

[17]  T. Komeda,et al.  Excitation of molecular vibrational modes with inelastic scanning tunneling microscopy processes: examination through action spectra of cis-2-butene on Pd(110). , 2005, Physical review letters.

[18]  Heather L. Tierney,et al.  Engineering Dislocation Networks for the Directed Assembly of Two-Dimensional Rotor Arrays , 2009 .

[19]  C. Joachim,et al.  Lander on Cu(2 1 1) – selective adsorption and surface restructuring by a molecular wire , 2003 .

[20]  Robert D. Horansky,et al.  The dielectric response of chloromethylsilyl and dichloromethylsilyl dipolar rotors on fused silica surfaces , 2002 .

[21]  Ben L. Feringa,et al.  Light-Driven Molecular Rotor: Unidirectional Rotation Controlled by a Single Stereogenic Center , 2000 .

[22]  Dominik Horinek,et al.  Molecular dynamics simulation of an electric field driven dipolar molecular rotor attached to a quartz glass surface. , 2003, Journal of the American Chemical Society.

[23]  R. Astumian,et al.  Making molecules into motors. , 2001, Scientific American.

[24]  Christian Joachim,et al.  A rack-and-pinion device at the molecular scale. , 2007, Nature materials.

[25]  J. C. Price,et al.  Dipolar rotor-rotor interactions in a difluorobenzene molecular rotor crystal , 2006 .

[26]  Ben L. Feringa,et al.  Toward a switchable molecular rotor. Unexpected dynamic behavior of functionalized overcrowded alkenes , 1997 .

[27]  Wilson Ho,et al.  Coupling of Vibrational Excitation to the Rotational Motion of a Single Adsorbed Molecule , 1998 .

[28]  Ben L. Feringa,et al.  Unidirectional molecular motor on a gold surface , 2005, Nature.

[29]  B. Feringa,et al.  In control of motion: from molecular switches to molecular motors. , 2001, Accounts of chemical research.

[30]  James M. Tour,et al.  Synthesis of a dipolar nanocar , 2007 .

[31]  B. V. Rao,et al.  Measurement of a linear free energy relationship one molecule at a time , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. Garcia‐Garibay,et al.  Molecular compasses and gyroscopes with polar rotors: synthesis and characterization of crystalline forms. , 2003, Journal of the American Chemical Society.

[33]  M. Ratner,et al.  Molecular Dipole Chains III: Energy Transfer , 2004 .

[34]  J. Tour,et al.  Directional control in thermally driven single-molecule nanocars. , 2005, Nano letters.

[35]  Dominik Horinek,et al.  Artificial Molecular Rotors , 2005 .

[36]  J. Michl,et al.  Artificial Surface‐Mounted Molecular Rotors: Molecular Dynamics Simulations , 2007 .

[37]  W. Akers,et al.  Hydrophilic molecular rotor derivatives-synthesis and characterization. , 2004, Bioorganic chemistry.

[38]  Francesco Zerbetto,et al.  Synthetic molecular motors and mechanical machines. , 2007, Angewandte Chemie.

[39]  James M Tour,et al.  Micrometer-scale translation and monitoring of individual nanocars on glass. , 2009, ACS nano.

[40]  Dominik Horinek,et al.  Dipolar and nonpolar altitudinal molecular rotors mounted on an Au(111) surface. , 2004, Journal of the American Chemical Society.

[41]  B. V. Rao,et al.  2,5-dichlorothiophenol on Cu(111): Initial adsorption site and scanning tunnel microscope-based abstraction of hydrogen at high intramolecular selectivity , 2003 .

[42]  Rozenbaum.  Coulomb interactions in two-dimensional lattice structures. , 1996, Physical review. B, Condensed matter.

[43]  R. Astumian.  Thermodynamics and kinetics of a Brownian motor. , 1997, Science.

[44]  C Joachim,et al.  Recording intramolecular mechanics during the manipulation of a large molecule. , 2001, Physical review letters.

[45]  C. Joachim,et al.  Recording the intramolecular deformation of a 4-legs molecule during its STM manipulation on a Cu(2 1 1) surface , 2005 .

[46]  David Bebbington,et al.  A Molecular Brake , 1994 .

[47]  M. Ratner,et al.  Local Field Controlled Switching in a One-Dimensional Dipolar Array , 2007 .

[48]  M. Schliwa,et al.  Molecular motors , 2003, Nature.

[49]  Nathalie Katsonis,et al.  Molecular machines: Nanomotor rotates microscale objects , 2006, Nature.

[50]  Miguel A. Garcia-Garibay,et al.  Amphidynamic character of crystalline MOF-5: rotational dynamics of terephthalate phenylenes in a free-volume, sterically unhindered environment. , 2008, Journal of the American Chemical Society.

[51]  M. Garcia‐Garibay,et al.  Rotational dynamics in a crystalline molecular gyroscope by variable-temperature 13C NMR, 2H NMR, X-ray diffraction, and force field calculations. , 2007, Journal of the American Chemical Society.

[52]  Burkhard König,et al.  Chemistry in motion--unidirectional rotating molecular motors. , 2004, Angewandte Chemie.

[53]  Ke Wen,et al.  Phospholipid-bound molecular rotors: synthesis and characterization. , 2002, Bioorganic & medicinal chemistry.

[54]  N. Harada,et al.  Light-driven monodirectional molecular rotor , 2022 .

[55]  R. Astumian.  Adiabatic operation of a molecular machine , 2007, Proceedings of the National Academy of Sciences.

[56]  Heather L. Tierney,et al.  Dynamics of Thioether Molecular Rotors: Effects of Surface Interactions and Chain Flexibility , 2009 .

[57]  Joachim,et al.  Rotation of a single molecule within a supramolecular bearing , 1998, Science.

[58]  N. Hush,et al.  An Azanorbornadiene Anchor For Molecular-Level Construction On Silicon(100) , 2004 .

[59]  M. Kuimova,et al.  Molecular rotor measures viscosity of live cells via fluorescence lifetime imaging. , 2008, Journal of the American Chemical Society.

[60]  J. C. Price,et al.  Artificial Dipolar Molecular Rotors , 2007 .

[61]  Richard A. Silva,et al.  A Rationally Designed Prototype of a Molecular Motor. , 2000, Journal of the American Chemical Society.

[62]  T. Komeda,et al.  Observation of cis-2-butene molecule on Pd(110) by cryogenic STM: site determination using tunneling-current-induced rotation , 2003 .

[63]  P. Weiss,et al.  Controlled Adsorption Orientation for Double-Decker Complexes , 2007 .

[64]  M. Garcia‐Garibay,et al.  Crystalline molecular machines: a quest toward solid-state dynamics and function. , 2006, Accounts of chemical research.

[65]  Ho,et al.  Inducing and viewing the rotational motion of a single molecule , 1998, Science.

[66]  J. C. Price,et al.  Dipolar molecular rotors in the metal-organic framework crystal IRMOF-2. , 2008, Physical chemistry chemical physics : PCCP.

[67]  Josef Michl,et al.  Molecular dynamics of a grid-mounted molecular dipolar rotor in a rotating electric field , 2001, Proceedings of the National Academy of Sciences of the United States of America.