A Smad Transcriptional Corepressor

[1]  P. Hoodless,et al.  Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. , 1998, Molecular cell.

[2]  Scott E. Kern,et al.  DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1 , 1996, Science.

[3]  A. Wolffe,et al.  Histone Deacetylase--A Regulator of Transcription , 1996, Science.

[4]  E. Harlow,et al.  Antibodies: A Laboratory Manual , 1988 .

[5]  Irene L Andrulis,et al.  MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma , 1996, Cell.

[6]  Xin Chen,et al.  A transcriptional partner for MAD proteins in TGF-β signalling , 1996, Nature.

[7]  L. Chin,et al.  Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression , 1997, nature.

[8]  J. Massagué,et al.  Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. , 1998, Genes & development.

[9]  P. D. Vize,et al.  Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo. , 1995, The EMBO journal.

[10]  J. Graff,et al.  Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo , 1994, Cell.

[11]  J. Massagué,et al.  Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex , 1995, Molecular and cellular biology.

[12]  K. Struhl,et al.  Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters , 1997, Cell.

[13]  Stuart L Schreiber,et al.  Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A , 1997, Cell.

[14]  R. Derynck,et al.  The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. , 1998, Genes & development.

[15]  Wen‐Ming Yang,et al.  Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression , 1997, Cell.

[16]  Alan P. Wolffe,et al.  A positive role for histone acetylation in transcription factor access to nucleosomal DNA , 1993, Cell.

[17]  J. Massagué,et al.  Physical and Functional Interaction of SMADs and p300/CBP* , 1998, The Journal of Biological Chemistry.

[18]  J. Massagué,et al.  Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 , 1997, Nature.

[19]  P. Hoodless,et al.  MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways , 1996, Cell.

[20]  Minoru Watanabe,et al.  Smad4 and FAST-1 in the assembly of activin-responsive factor , 1997, Nature.

[21]  T. Hunter,et al.  TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. , 1998, Genes & development.

[22]  J. Wrana,et al.  The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling , 1997, Cell.

[23]  J. Massagué TGF-beta signal transduction. , 1998, Annual review of biochemistry.

[24]  Kirby D. Johnson,et al.  Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic , 1997, Nature.

[25]  B. Howard,et al.  The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases , 1996, Cell.

[26]  G. Campbell,et al.  Transducing the Dpp Morphogen Gradient in the Wing of Drosophila Regulation of Dpp Targets by brinker , 1999, Cell.

[27]  H. Moses,et al.  Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. , 1988, The Journal of biological chemistry.

[28]  M. Vettese-Dadey,et al.  Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. , 1996, The EMBO journal.

[29]  R. Derynck,et al.  Receptor-associated Mad homologues synergize as effectors of the TGF-β response , 1996, Nature.

[30]  C. Abate-Shen,et al.  A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. Rossant,et al.  The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. , 1998, Genes & development.

[32]  Yigong Shi,et al.  Crystal Structure of a Smad MH1 Domain Bound to DNA Insights on DNA Binding in TGF-β Signaling , 1998, Cell.

[33]  J. Baker,et al.  A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. , 1996, Genes & development.

[34]  J. Massagué,et al.  TGF- SIGNAL TRANSDUCTION , 1998 .

[35]  Ya-Li Yao,et al.  Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family* , 1997, The Journal of Biological Chemistry.

[36]  S. White Dual role , 1996, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[37]  J. Massagué,et al.  The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. , 1997, Genes & development.

[38]  J. Massagué,et al.  Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways , 1996, Nature.

[39]  J. Graff,et al.  Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily , 1996, Cell.

[40]  S. Schreiber,et al.  Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase , 1997, Cell.

[41]  Andrew J. Bannister,et al.  The CBP co-activator is a histone acetyltransferase , 1996, Nature.

[42]  J. Massagué,et al.  Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway , 1999, Nature.

[43]  M. Levine,et al.  Transcriptional repression in development. , 1996, Current opinion in cell biology.

[44]  L. Dobens,et al.  Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. , 1998, Development.

[45]  J. Massagué,et al.  Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. , 1999, Nature.

[46]  E. Bradbury,et al.  Acetylation of histone H4 and its role in chromatin structure and function , 1980, Nature.

[47]  P. Hoodless,et al.  MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling , 1996, Cell.

[48]  Yigong Shi,et al.  A structural basis for mutational inactivation of the tumour suppressor Smad4 , 1997, Nature.

[49]  J. Massagué,et al.  A human Mad protein acting as a BMP-regulated transcriptional activator , 1996, Nature.

[50]  D. Reinberg,et al.  Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex , 1997, Cell.

[51]  T R Bürglin,et al.  Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. , 1997, Nucleic acids research.

[52]  R. Brent,et al.  Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites , 1993, Cell.

[53]  P. Hoodless,et al.  Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2* , 1998, The Journal of Biological Chemistry.

[54]  Kohei Miyazono,et al.  TGF-β signalling from cell membrane to nucleus through SMAD proteins , 1997, Nature.

[55]  K. Irie,et al.  The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3 , 1998, Nature.

[56]  C. Glass,et al.  A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression , 1997, nature.

[57]  J. Berthelsen,et al.  Prep1, a novel functional partner of Pbx proteins , 1998, The EMBO journal.

[58]  E. Bertolino,et al.  A Novel Homeobox Protein Which Recognizes a TGT Core and Functionally Interferes with a Retinoid-responsive Motif (*) , 1995, The Journal of Biological Chemistry.

[59]  C. Heldin,et al.  Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling , 1997, Nature.

[60]  E. Li,et al.  Smad2 role in mesoderm formation, left–right patterning and craniofacial development , 1998, Nature.

[61]  Yigong Shi,et al.  The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors , 1998, The EMBO journal.

[62]  K. Struhl Histone acetylation and transcriptional regulatory mechanisms. , 1998, Genes & development.

[63]  P. Hoodless,et al.  Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo , 1998, Cell.

[64]  E. Wieschaus,et al.  The Drosophila Gene brinker Reveals a Novel Mechanism of Dpp Target Gene Regulation , 1999, Cell.

[65]  E. Lai,et al.  FAST-2 Is a Mammalian Winged-Helix Protein Which Mediates Transforming Growth Factor β Signals , 1999, Molecular and Cellular Biology.

[66]  J. Manley,et al.  Even-skipped Represses Transcription by Binding TATA Binding Protein and Blocking the TFIID-TATA Box Interaction , 1998, Molecular and Cellular Biology.

[67]  K. Miyazono,et al.  Smad6 inhibits signalling by the TGF-β superfamily , 1997, Nature.

[68]  S. Schreiber,et al.  A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p , 1996, Science.

[69]  J. Sekelsky,et al.  Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. , 1995, Genetics.

[70]  J. Massagué,et al.  A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. , 1999, Genes & development.

[71]  Hiroyuki Miyoshi,et al.  Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes , 1998, Cell.

[72]  M. Kretzschmar,et al.  Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1 , 1997, Nature.

[73]  J. Massagué,et al.  Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. , 1997, Genes & development.

[74]  J. Berthelsen,et al.  The novel homeoprotein Prep1 modulates Pbx–Hox protein cooperativity , 1998, The EMBO journal.

[75]  J. Massagué,et al.  Smad 6 inhibits BMP / Smad 1 signaling by specifically competing with the Smad 4 tumor suppressor , 1998 .

[76]  Takeshi Imamura,et al.  TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4 , 1997 .