Heat shock proteins – modulators of apoptosis in tumour cells

[1]  T. Cotter,et al.  Heat shock protein 70 inhibits caspase-dependent and -independent apoptosis in Jurkat T cells. , 2000, Experimental cell research.

[2]  Y Li,et al.  [Mitochondria and apoptosis]. , 2000, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

[3]  G. Chinnadurai,et al.  Modulation of Mitochondrial Ca2+ Homeostasis by Bcl-2* , 1999, The Journal of Biological Chemistry.

[4]  E. Solary,et al.  HSP27 inhibits cytochrome c‐dependent activation of procaspase‐9 , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  R. von Harsdorf,et al.  p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c‐independent apoptosis blocked by Bcl‐2 , 1999, The EMBO journal.

[6]  H. Kang,et al.  Geldanamycin Induces Heat Shock Protein Expression Through Activation of HSF1 in K562 Erythroleukemic Cells , 1999, IUBMB life.

[7]  G. Kroemer,et al.  Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death , 1999, Cell Death and Differentiation.

[8]  L. Sistonen,et al.  Differentiation lineage‐specific expression of human heat shock transcription factor 2 , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  Creagh,et al.  Selective protection by hsp 70 against cytotoxic drug‐, but not Fas‐induced T‐cell apoptosis , 1999, Immunology.

[10]  H. Thé,et al.  In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARα protein and the PML retargeting on PML-nuclear bodies , 1999, Leukemia.

[11]  X. Liu,et al.  An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9* , 1999, The Journal of Biological Chemistry.

[12]  B. Zhivotovsky,et al.  Presence of a pre‐apoptotic complex of pro‐caspase‐3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells , 1999, The EMBO journal.

[13]  P. Tawa,et al.  Hsp60 accelerates the maturation of pro‐caspase‐3 by upstream activator proteases during apoptosis , 1999, The EMBO journal.

[14]  J. Roth,et al.  Signaling defect in the activation of caspase-3 and PKCdelta in human TUR leukemia cells is associated with resistance to apoptosis. , 1999, Experimental cell research.

[15]  M. Komeda,et al.  Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heart. , 1999, Circulation.

[16]  T G Cotter,et al.  Antioxidant‐mediated inhibition of the heat shock response leads to apoptosis , 1999, FEBS letters.

[17]  Ruedi Aebersold,et al.  Molecular characterization of mitochondrial apoptosis-inducing factor , 1999, Nature.

[18]  M. Zhou,et al.  The clinical significance of Fas expression in leukemia: questions and controversies , 1999, Leukemia.

[19]  M. Prevost,et al.  Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process , 1999, The Journal of experimental medicine.

[20]  S. H. Kim,et al.  Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells. , 1998, The American journal of pathology.

[21]  S. Nagata,et al.  Caspase-independent Cell Killing by Fas-associated Protein with Death Domain , 1998, The Journal of cell biology.

[22]  Y. Lee,et al.  Metabolic Oxidative Stress-induced HSP70 Gene Expression Is Mediated through SAPK Pathway , 1998, The Journal of Biological Chemistry.

[23]  M. Jäättelä,et al.  Hsp70 exerts its anti‐apoptotic function downstream of caspase‐3‐like proteases , 1998, The EMBO journal.

[24]  G. Brittinger,et al.  In Acute Myeloid Leukemia only the Coexpression of at Least Two Proteins Including P-Glycoprotein, the Multidrug Resistance-Related Protein MRP, bcl-2, Mutant p53 and Heat-Shock Protein 27 is Predictive for the Response to Induction Chemotherapy , 1998 .

[25]  P. Krammer,et al.  CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Minden,et al.  Antileukemic action of buthionine sulfoximine: evidence for an intrinsic death mechanism based on oxidative stress , 1998, Leukemia.

[27]  J. Buchner,et al.  The Hsp90 complex--a super-chaperone machine as a novel drug target. , 1998, Biochemical pharmacology.

[28]  V. Dixit,et al.  Death receptors: signaling and modulation. , 1998, Science.

[29]  Y. Lazebnik,et al.  Caspases: enemies within. , 1998, Science.

[30]  S. Cory,et al.  The Bcl-2 protein family: arbiters of cell survival. , 1998, Science.

[31]  R. Voellmy,et al.  Repression of Heat Shock Transcription Factor HSF1 Activation by HSP90 (HSP90 Complex) that Forms a Stress-Sensitive Complex with HSF1 , 1998, Cell.

[32]  J. Mazat,et al.  From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state. , 1998, Biochimica et biophysica acta.

[33]  G. Bokoch.  Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction? , 1998, Cell Death and Differentiation.

[34]  J C Reed,et al.  Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. , 1998, Cancer research.

[35]  A. Giaccia,et al.  Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis* , 1998, The Journal of Biological Chemistry.

[36]  Sun-Hee Kim,et al.  Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells , 1998, Experimental & Molecular Medicine.

[37]  V. Cryns,et al.  Proteases to die for. , 1998, Genes & development.

[38]  J C Reed,et al.  Bax directly induces release of cytochrome c from isolated mitochondria. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[39]  K. Schulze-Osthoff,et al.  Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression* , 1998, The Journal of Biological Chemistry.

[40]  T. Finkel.  Oxygen radicals and signaling. , 1998, Current opinion in cell biology.

[41]  N. Thornberry,et al.  The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling , 1998, The Journal of cell biology.

[42]  C. Widmann,et al.  Caspase-dependent Cleavage of Signaling Proteins during Apoptosis , 1998, The Journal of Biological Chemistry.

[43]  M. Peter,et al.  Two CD95 (APO‐1/Fas) signaling pathways , 1998, The EMBO journal.

[44]  P. Branton,et al.  E4orf4, a Novel Adenovirus Death Factor That Induces p53-independent Apoptosis by a Pathway That Is Not Inhibited by zVAD-fmk , 1998, The Journal of cell biology.

[45]  D G Kirsch,et al.  Modulation of cell death by Bcl-XL through caspase interaction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[46]  E. Cheng,et al.  Conversion of Bcl-2 to a Bax-like death effector by caspases. , 1997, Science.

[47]  J. D. Robertson,et al.  Bcl-xL overexpression restricts heat-induced apoptosis and influences hsp70, bcl-2, and Bax protein levels in FL5.12 cells. , 1997, Biochemical and biophysical research communications.

[48]  P. Hugo,et al.  CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway. , 1997, Journal of immunology.

[49]  S. Srinivasula,et al.  Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade , 1997, Cell.

[50]  Y. Yamaoka,et al.  Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid. , 1997, Cancer research.

[51]  J. Hurwitz,et al.  The large subunit of replication factor C is a substrate for caspase‐3 in vitro and is cleaved by a caspase‐3‐like protease during Fas‐mediated apoptosis , 1997, The EMBO journal.

[52]  M. Jäättelä,et al.  The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type , 1997, Journal of virology.

[53]  L. Bourget,et al.  Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis , 1997, Molecular and cellular biology.

[54]  John Calvin Reed,et al.  BAG‐1 modulates the chaperone activity of Hsp70/Hsc70 , 1997, The EMBO journal.

[55]  Xiaodong Wang,et al.  Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 , 1997, Cell.

[56]  Dick D. Mosser,et al.  Hsp70 Prevents Activation of Stress Kinases , 1997, The Journal of Biological Chemistry.

[57]  I. Guénal,et al.  Bcl-2 and Hsp27 act at different levels to suppress programmed cell death , 1997, Oncogene.

[58]  B. Chauffert,et al.  HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. , 1997, Cancer research.

[59]  X. Ding,et al.  Overexpression of the heat shock protein 70 enhances the TCR/CD3- and Fas/Apo-1/CD95-mediated apoptotic cell death in Jurkat T cells. , 1997, Journal of immunology.

[60]  J. Wang,et al.  Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses. , 1997, The American journal of physiology.

[61]  F. Trautinger,et al.  Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line. , 1997, Journal of photochemistry and photobiology. B, Biology.

[62]  M. Quaia,et al.  Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients. , 1997, European journal of cancer.

[63]  Neal Rosen,et al.  Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent , 1997, Cell.

[64]  T. Cotter,et al.  Role of peroxide and superoxide anion during tumour cell apoptosis , 1997, FEBS letters.

[65]  Y. Komada,et al.  Fas receptor (CD95)-mediated apoptosis in leukemic cells. , 1997, Leukemia & lymphoma.

[66]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[67]  G. Evan,et al.  Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak , 1997, The Journal of cell biology.

[68]  Minoru Takagi,et al.  Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways , 1997, Science.

[69]  D. Latchman,et al.  Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology. , 1996, Journal of immunology.

[70]  G. Kroemer,et al.  Bcl-2 inhibits the mitochondrial release of an apoptogenic protease , 1996, The Journal of experimental medicine.

[71]  L. Neckers,et al.  Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway , 1996, Molecular and cellular biology.

[72]  T. Cotter,et al.  Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP‐ribose)polymerase (PARP) cleavage and apoptosis , 1996, FEBS letters.

[73]  C. Franceschi,et al.  Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytes. , 1996, International journal of radiation biology.

[74]  L. Neckers,et al.  Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[75]  D. Chan,et al.  Interleukin-1 beta-converting enzyme-like protease cleaves DNA- dependent protein kinase in cytotoxic T cell killing , 1996, The Journal of experimental medicine.

[76]  D C Linch,et al.  Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study. , 1996, Blood.

[77]  Xiaodong Wang,et al.  Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c , 1996, Cell.

[78]  K. Schulze-Osthoff,et al.  Small Stress Proteins as Novel Regulators of Apoptosis , 1996, The Journal of Biological Chemistry.

[79]  A. Rossi,et al.  Inhibition of HSP70 Expression by Calcium Ionophore A23187 in Human Cells , 1996, The Journal of Biological Chemistry.

[80]  M. Simon,et al.  Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. , 1996, British Journal of Cancer.

[81]  S. Orrenius,et al.  Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody* , 1996, The Journal of Biological Chemistry.

[82]  C. Franceschi,et al.  Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[83]  David Wallach,et al.  Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death , 1996, Cell.

[84]  Matthias Mann,et al.  FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex , 1996, Cell.

[85]  K. Goi,et al.  Mechanisms of glucocorticoid resistance in human leukemic cells: implication of abnormal 90 and 70 kDa heat shock proteins. , 1996, Leukemia.

[86]  P. Rose,et al.  Susceptibility of AML cells to in vitro apoptosis correlates with heat shock protein 70 (hsp70) expression , 1996, British journal of haematology.

[87]  P. Mehlen,et al.  Human hsp27, Drosophila hsp27 and human alphaB‐crystallin expression‐mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha‐induced cell death. , 1996, The EMBO journal.

[88]  L. Weber,et al.  Effect of overexpression of the small heat shock protein HSP27 on the heat and drug sensitivities of human testis tumor cells. , 1996, Cancer research.

[89]  S. Nagata,et al.  Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis , 1996, Nature.

[90]  M. Castedo,et al.  Mitochondrial control of nuclear apoptosis , 1996, The Journal of experimental medicine.

[91]  H. Liu,et al.  Activation of Heat Shock Factor by Alkylating Agents Is Triggered by Glutathione Depletion and Oxidation of Protein Thiols (*) , 1996, The Journal of Biological Chemistry.

[92]  S. Horman,et al.  ANTISENSE INHIBITION OF THE 27 kDa HEAT SHOCK PROTEIN PRODUCTION AFFECTS GROWTH RATE AND CYTOSKELETAL ORGANIZATION IN MCF‐7 CELLS , 1996, Cell biology international.

[93]  T G Cotter,et al.  Heat shock proteins increase resistance to apoptosis. , 1996, Experimental cell research.

[94]  R. Shoemaker,et al.  Overlapping phenotypes of multidrug resistance among panels of human cancer‐cell lines , 1996, International journal of cancer.

[95]  Michael E. Greenberg,et al.  Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis , 1995, Science.

[96]  M. Peter,et al.  Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor. , 1995, The EMBO journal.

[97]  R. Ralhan,et al.  Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix. , 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

[98]  Patrick R. Griffin,et al.  Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis , 1995, Nature.

[99]  V. Dixit,et al.  Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. , 1995, Oncogene.

[100]  W. Murdoch.  Temporal relationships between stress protein induction, progesterone withdrawal, and apoptosis in corpora lutea of ewes treated with prostaglandin F2 alpha. , 1995, Journal of animal science.

[101]  P. Rose,et al.  Analysis of heat‐shock protein expression in myeloid leukaemia cells by flow cytometry , 1995, British journal of haematology.

[102]  R. Morimoto,et al.  Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ‐1. , 1995, The EMBO journal.

[103]  S. Orrenius,et al.  Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. , 1995, The Biochemical journal.

[104]  C. Thompson,et al.  Apoptosis in the pathogenesis and treatment of disease , 1995, Science.

[105]  M. Simon,et al.  Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release. , 1995, The Journal of clinical investigation.

[106]  P. Mehlen,et al.  Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts. , 1995, Journal of immunology.

[107]  Aaron Ciechanover,et al.  The ubiquitin-proteasome proteolytic pathway , 1994, Cell.

[108]  S. Nagata,et al.  No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis , 1994, FEBS letters.

[109]  J. Behlke,et al.  Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. , 1994, The Journal of biological chemistry.

[110]  R. Cohen,et al.  hsc70 moderates the heat shock (stress) response in Xenopus laevis oocytes and binds to denatured protein inducers. , 1994, The Journal of biological chemistry.

[111]  P. Barr,et al.  Apoptosis and Its Role in Human Disease , 1994, Bio/Technology.

[112]  K. Khanna,et al.  Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA. , 1994, Biochemical and biophysical research communications.

[113]  Takashi Suda,et al.  Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family , 1993, Cell.

[114]  M. Jäättelä,et al.  Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2. , 1993, Journal of immunology.

[115]  D. D. Mosser,et al.  The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70 , 1993, Molecular and cellular biology.

[116]  S. Nagata,et al.  Lethal effect of the anti-Fas antibody in mice , 1993, Nature.

[117]  S. Nagata,et al.  Effect of bcl-2 on Fas antigen-mediated cell death. , 1993, Journal of immunology.

[118]  J. Albina,et al.  Nitric oxide-mediated apoptosis in murine peritoneal macrophages. , 1993, Journal of immunology.

[119]  J. Magaud,et al.  High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. , 1993, Blood.

[120]  W. Fiers,et al.  Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. , 1993, Oncogene.

[121]  M. Jäättelä,et al.  Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection , 1993, The Journal of experimental medicine.

[122]  C. Haslett.  Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. , 1992, Clinical science.

[123]  S. Lindquist.  Heat-shock proteins and stress tolerance in microorganisms , 1992, Current Biology.

[124]  D. Green,et al.  Apoptotic cell death induced by c-myc is inhibited by bcl-2 , 1992, Nature.

[125]  M. Jäättelä,et al.  Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity. , 1992, The EMBO journal.

[126]  P. Hainaut,et al.  Interaction of heat‐shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation. , 1992, The EMBO journal.

[127]  John Calvin Reed,et al.  bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. , 1992, Cancer research.

[128]  W. Welch.  Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. , 1992, Physiological reviews.

[129]  J. Buchner,et al.  Hsp90 chaperones protein folding in vitro , 1992, Nature.

[130]  A. Nègre-Salvayre,et al.  Oxidized low density lipoproteins elicit DNA fragmentation of cultured lymphoblastoid cells , 1992, FEBS letters.

[131]  R. Baler,et al.  Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factor , 1992, The Journal of cell biology.

[132]  G. Li,et al.  Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[133]  W. Fiers,et al.  Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation. , 1992, The Journal of biological chemistry.

[134]  R. Floyd.  Oxidative damage to behavior during aging. , 1991, Science.

[135]  S. Korsmeyer,et al.  bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes , 1991, Cell.

[136]  L. Hightower,et al.  Heat shock, stress proteins, chaperones, and proteotoxicity , 1991, Cell.

[137]  B. Geiger,et al.  A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein , 1991, The Journal of cell biology.

[138]  C. Angelidis,et al.  Constitutive expression of heat-shock protein 70 in mammalian cells confers thermoresistance. , 1991, European journal of biochemistry.

[139]  R. Floyd,et al.  Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[140]  Seamus J. Martin,et al.  Dose‐dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli , 1991, Cell proliferation.

[141]  G. Evan,et al.  Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells , 1991, Journal of virology.

[142]  R. Schreiber,et al.  Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death , 1990, Nature.

[143]  S. Lindquist,et al.  HSP104 required for induced thermotolerance. , 1990, Science.

[144]  W. Welch,et al.  Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. , 1990, Science.

[145]  T. Waldmann,et al.  Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia , 1990, The Lancet.

[146]  A. Yagihashi,et al.  Heat- or stress-inducible transformation-associated cell surface antigen on the activated H-ras oncogene-transfected rat fibroblast. , 1989, Cancer research.

[147]  P. Möller,et al.  Monoclonal antibody-mediated tumor regression by induction of apoptosis. , 1989, Science.

[148]  W. Welch,et al.  Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock protein , 1988, Molecular and cellular biology.

[149]  J. Hickman,et al.  Investigation of the effects of heat shock and agents which induce a heat shock response on the induction of differentiation of HL-60 cells. , 1988, Cancer research.

[150]  P. Chrétien,et al.  Enhanced constitutive expression of the 27‐kDa heat shock proteins in heat‐resistant variants from chinese hamster cells , 1988, Journal of cellular physiology.

[151]  A. Rougvie,et al.  The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged , 1988, Cell.

[152]  B. Halliwell.  Oxidants and human disease: some new concepts , 1987 .

[153]  M. Kasuga,et al.  Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[154]  S. Lindquist,et al.  RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis , 1986, Cell.

[155]  Carl Wu.  The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I , 1980, Nature.

[156]  S. Lindquist,et al.  Translational efficiency of heat-induced messages in Drosophila melanogaster cells. , 1980, Journal of molecular biology.

[157]  A. Tissières,et al.  Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. , 1974, Journal of molecular biology.

[158]  P. Colussi,et al.  Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis. , 1999, Trends in biochemical sciences.

[159]  G. Kroemer,et al.  The mitochondrial death/life regulator in apoptosis and necrosis. , 1998, Annual review of physiology.

[160]  D. Green,et al.  Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization , 1998, The EMBO journal.

[161]  D. Chao,et al.  BCL-2 family: regulators of cell death. , 1998, Annual review of immunology.

[162]  A. Arrigo.  Small stress proteins: chaperones that act as regulators of intracellular redox state and programmed cell death. , 1998, Biological chemistry.

[163]  G. Brittinger,et al.  In acute myeloid leukemia, coexpression of at least two proteins, including P-glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat-shock protein 27, is predictive of the response to induction chemotherapy. , 1998, Experimental hematology.

[164]  L. Neckers,et al.  Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity , 1997, Cancer Chemotherapy and Pharmacology.

[165]  R. Morimoto,et al.  The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. , 1997, Essays in biochemistry.

[166]  W. Pratt.  The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinase. , 1997, Annual review of pharmacology and toxicology.

[167]  T. McDonnell,et al.  Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. , 1996, Leukemia.

[168]  G. Zauli,et al.  Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein. , 1994, The Journal of general virology.

[169]  T. Buttke,et al.  Oxidative stress as a mediator of apoptosis. , 1994, Immunology today.

[170]  B. P. Yu,et al.  Cellular defenses against damage from reactive oxygen species. , 1994, Physiological reviews.

[171]  F. Hartl,et al.  10 Molecular Chaperone Functions of hsp70 and hsp60 in Protein Folding , 1994 .

[172]  John T. Lis,et al.  15 Structure and Regulation of Heat Shock Gene Promoters , 1994 .

[173]  R. Morimoto,et al.  17 Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors , 1994 .

[174]  Carl Wu,et al.  16 Structure and Regulation of Heat Shock Transcription Factor , 1994 .

[175]  B. Polla,,et al.  Hsp70--a multi-gene, multi-structure, multi-function family with potential clinical applications. , 1994, Experientia.

[176]  F. Hartl,et al.  Molecular chaperone functions of heat-shock proteins. , 1993, Annual review of biochemistry.

[177]  C. Gross,et al.  Is hsp70 the cellular thermometer? , 1991, Trends in biochemical sciences.

[178]  A. Wyllie,et al.  Apoptosis: mechanisms and roles in pathology. , 1991, International review of experimental pathology.

[179]  W. Troll.  Prevention of cancer by agents that suppress oxygen radical formation. , 1991, Free radical research communications.

[180]  G. Kass,et al.  Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiation. , 1991, Chemico-biological interactions.

[181]  J. Becker,et al.  On the mechanism of action of H2O2 in the cellular stress. , 1991, Free radical research communications.

[182]  R. Kuick,et al.  Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins. , 1990, The Journal of clinical investigation.

[183]  J. Holmes,et al.  Multidrug Resistance in Leukaemia. , 1990, Leukemia & lymphoma.

[184]  L. Zwelling.  Topoisomerase II as a target of antileukemia drugs: a review of controversial areas. , 1989, Hematologic pathology.

[185]  E. Craig,et al.  The heat shock response. , 1985, CRC critical reviews in biochemistry.

[186]  J. Kerr,et al.  Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance. , 1982, Pathology annual.

[187]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.