Risk factors for wheezing, eczema and rhinoconjunctivitis in the previous 12 months among six-year-old children in Himeji City, Japan: food allergy, older siblings, day-care attendance and parental allergy history.

BACKGROUND The aim of this study was to clarify whether some environmental and genetic factors (food allergy, older siblings, early day-care attendance and parents' allergy history) are related to the development of allergic symptoms (wheezing in the previous 12 months [WP], eczema symptoms in the previous 12 months [EP], and rhinoconjunctivitis symptoms in the previous 12 months [RP]) in Japanese children. METHODS Using the modified version of the International Study on Asthma and Allergies in Childhood (ISSAC) questionnaire, we studied the prevalence of WP, EP and RP among six-year-old children attending 72 primary schools throughout Himeji City, Japan, during the two years from 2005 to 2006. RESULTS Food allergy and parents' history of allergy showed a significant relationship with the prevalence of WP, EP and RP. Day-care attendance in the first two years of life and presence of older siblings showed a significant inverse relationship with the prevalence of RP. However, neither day-care attendance nor presence of older siblings was related to the development of W and ER. CONCLUSIONS Among Japanese children, food allergy and parents' history of allergy are risk factors for WP, ES or RS. However, early day-care attendance and presence of older siblings might be protective factors against RS. Infections in early life may affect the prevalence of rhinoconjunctivitis in six-year-old children.

[1]  J. Ring,et al.  Contact to cat or dog, allergies and parental education , 2010, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[2]  S. Sasaki,et al.  Sibship size and prevalence of allergic disorders in Japan: The Ryukyus Child Health Study , 2009, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[3]  Y. Ohya,et al.  Breastfeeding and atopic eczema in Japanese infants: The Osaka Maternal and Child Health Study , 2009, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[4]  D. Johns,et al.  Relevance of the hygiene hypothesis to early vs. late onset allergic rhinitis , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[5]  C. Bindslev‐Jensen,et al.  The prevalence of allergic diseases in an unselected group of 6‐year‐old children. The DARC birth cohort study , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[6]  Y. Ohya,et al.  Breastfeeding and the risk of wheeze and asthma in Japanese infants: The Osaka Maternal and Child Health Study , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[7]  Jennifer S. Kim,et al.  Associations Between Eczema and Food Allergy in Children , 2008 .

[8]  Y. Ohya,et al.  Dental Caries and Allergic Disorders in Japanese Children: The Ryukyus Child Health Study , 2008, The Journal of asthma : official journal of the Association for the Care of Asthma.

[9]  A. Custovic,et al.  Original article: Rhinoconjunctivitis in 5‐year‐old children: a population‐based birth cohort study , 2007, Allergy.

[10]  H. Nishio,et al.  Current cat ownership may be associated with the lower prevalence of atopic dermatitis, allergic rhinitis, and Japanese cedar pollinosis in schoolchildren in Himeji, Japan , 2006, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[11]  S. Weiland,et al.  Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis: results from a cross‐sectional study , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[12]  P. Andersen,et al.  Sibship characteristics and risk of allergic rhinitis and asthma. , 2005, American journal of epidemiology.

[13]  R. Kurukulaaratchy,et al.  Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age. , 2005, Chest.

[14]  A. Gulsvik,et al.  Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. , 2003, The Journal of allergy and clinical immunology.

[15]  H. Sampson.  Anaphylaxis and emergency treatment. , 2003, Pediatrics.

[16]  Rosalind J Wright,et al.  Day care attendance in early life, maternal history of asthma, and asthma at the age of 6 years. , 2003, American journal of respiratory and critical care medicine.

[17]  A. Gulsvik,et al.  Early exposure to children in family and day care as related to adult asthma and hay fever: results from the European Community Respiratory Health Survey , 2002, Thorax.

[18]  S. Nishima,et al.  PREVALENCE OF CHILDHOOD ALLERGIC DISEASES IN JAPAN USING INTERNATIONAL STUDY OF ASTHMA AND ALLEGIES IN CHILDHOOD (ISAAC) PHASE I PROTOCAL , 2002 .

[19]  J. Castro‐Rodriguez,et al.  Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. , 2000, The New England journal of medicine.

[20]  E. P. Sarafino,et al.  Connections among parent and child atopic illnesses , 2000, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[21]  J. Pekkanen,et al.  Infections in early childhood and risk of atopic disease , 1999, Acta paediatrica.

[22]  Ichikawa,et al.  High prevalence of sensitization to cat allergen among Japanese children with asthma, living without cats , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[23]  M. Wjst,et al.  Age of entry to day nursery and allergy in later childhood , 1999, The Lancet.

[24]  P. Sly,et al.  Development of allergen-specific T-cell memory in atopic and normal children , 1999, The Lancet.

[25]  Hedberg,et al.  Perinatal risk factors for atopic disease in conscripts , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[26]  B. Cohen,et al.  Prevalence of IgE-Mediated Food Allergy Among Children With Atopic Dermatitis , 1998, Pediatrics.

[27]  A. Seaton,et al.  Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group. , 1998, Thorax.

[28]  J. Kaprio,et al.  Hay fever, asthma and number of older siblings — a twin study , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[29]  S. Chinn,et al.  Family size, atopic disorders in parents, asthma in children, and ethnicity. , 1997, Journal of Allergy and Clinical Immunology.

[30]  D. Jarvis,et al.  The association of family size with atopy and atopic disease , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[31]  D. Strachan,et al.  Sibship size and self‐reported inhalant allergy among adult women , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[32]  D. Strachan,et al.  Family structure, neonatal infection, and hay fever in adolescence. , 1996, Archives of disease in childhood.

[33]  D. Strachan,et al.  International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. , 1995, The European respiratory journal.

[34]  F. Martinez.  Role of viral infections in the inception of asthma and allergies during childhood: could they be protective? , 1994, Thorax.

[35]  P. Holt.  A potential vaccine strategy for asthma and allied atopic diseases during early childhood , 1994, The Lancet.

[36]  S. H. Arshad,et al.  The effect of genetic and environmental factors on the prevalence of allergic disorders at the age of two years , 1993, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[37]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[38]  M. de Martino,et al.  Foods and respiratory allergy. , 1988, The Journal of allergy and clinical immunology.

[39]  N. M. Kjellman,et al.  ATOPIC DISEASE IN SEVEN‐YEAR‐OLD CHILDREN Incidence in Relation to Family History , 1977, Acta paediatrica Scandinavica.

[40]  K. Furusho,et al.  Surveys on the prevalence of pediatric bronchial asthma in Japan: a comparison between the 1982, 1992, and 2002 surveys conducted in the same region using the same methodology. , 2009, Allergology international : official journal of the Japanese Society of Allergology.

[41]  C. Kiyohara,et al.  Environmental factors and allergic disorders. , 2007, Allergology international : official journal of the Japanese Society of Allergology.

[42]  Komei Ito,et al.  [Immediate type food hypersensitivity associated with atopic dermatitis in children]. , 2004, Arerugi = [Allergy].

[43]  P. Falconieri,et al.  Food allergy and asthma , 1995, Pediatric pulmonology. Supplement.

[44]  S. Romagnani.  Human TH1 and TH2 subsets: regulation of differentiation and role in protection and immunopathology. , 1992, International archives of allergy and immunology.