Clinical Courses of Schizophrenia

Abstract Schizophrenia is a complex disorder, characterized by molecular, neuroendocrine, and behavioral alterations as well as gene-environment interactions. This article summarizes key facts on the diagnosis, long-term course and neurocognitive deficits of schizophrenia. Due to the heterogeneity of schizophrenia with regard to symptomatology, illness manifestations, course and outcome, the focus of attention has shifted from diagnostic categories to endophenotypes which are hoped to characterize distinct subtypes of schizophrenia more appropriately than the diagnostic classification systems. The systems approach aims to assess the complexity and multiple dynamics of biological systems to explain endophenotypes of schizophrenia and their associations with susceptibility genes. Data presented in this paper support the view that looking for associations between neurocognitive endophenotypes and susceptibility genes might be a promising approach for future research to elucidate the heterogeneity of schizophrenic spectrum disorders.

[1]  N. Tarrier,et al.  Needs‐based cognitive‐behavioural family intervention for patients suffering from schizophrenia: 5‐year follow‐up of a randomized controlled effectiveness trial , 2007, Acta psychiatrica Scandinavica.

[2]  W. Eaton,et al.  Remission and relapse in schizophrenia: the Madras Longitudinal Study. , 1998, The Journal of nervous and mental disease.

[3]  M. Albus,et al.  Contrasts in neuropsychological test profile between patients with first‐eoisode schizophienia and first‐episohe affective disorders , 1996, Acta psychiatrica Scandinavica.

[4]  M. Shepherd,et al.  The natural history of schizophrenia: a 5-year prospective follow-up of a representative sample of schizophrenics by means of a standardized clinical and social assessment , 1983, Psychological Medicine.

[5]  P. Garety,et al.  Predicting recovery from schizophrenia: a retrospective comparison of characteristics at onset of people with single and multiple episodes. , 2005, Schizophrenia bulletin.

[6]  L. Grossman,et al.  Do patients with schizophrenia ever show periods of recovery? A 15-year multi-follow-up study. , 2005, Schizophrenia bulletin.

[7]  R Giel,et al.  Natural course of schizophrenic disorders: a 15-year followup of a Dutch incidence cohort. , 1998, Schizophrenia bulletin.

[8]  N. Smeeton,et al.  The natural history of schizophrenia: a five-year follow-up study of outcome and prediction in a representative sample of schizophrenics. , 1989, Psychological medicine. Monograph supplement.

[9]  G. Huber,et al.  Longitudinal studies of schizophrenic patients. , 1980, Schizophrenia bulletin.

[10]  G. Teschke.  Die schizophrenen Geistesstörungen im Lichte langjähriger Kranken- und Familiengeschichten, by Manfred Bleuler , 1978 .

[11]  Luc Ciompi,et al.  Lebensweg und Alter der Schizophrenen : eine katamnestische Langzeitstudie bis ins Senium, mit 27 Fallbeispielen , 1976 .