[Case of dermatomyositis with anti-CADM-140 antibody and alveolar hemorrhage].

A-47-year-old woman was admitted to our hospital because of eruption, severe arthritis, myalgia, pharyngalgia and the elevation of serum creatine kinase. She was diagnosed with dermatomyositis based on a biopsied specimen and clinical symptoms. Serum anti CADM-140 antibody was detected by immunoprecipitation. Pulse therapy with methylprednisolone and cyclophophamide could transiently improve myalgia and so on, but she died of rapidly progressive interstitial lung disease. Autopsy findings demonstrated diffuse alveolar damage and alveolar hemorrhage. It is said that patients with anti CADM-140 antibody show poor muscle symptoms and alveolar hemorrhage has been described very rarely. This patient is the rare case of dermatomyositis with anti CADM-140 antibody developing severe muscle symptoms, pharyngalgia and aleveolar hemorrhage in autopsy findings.

[1]  T. Fujita,et al.  Anti-CADM-140/MDA5 autoantibody titer correlates with disease activity and predicts disease outcome in patients with dermatomyositis and rapidly progressive interstitial lung disease , 2013, Modern rheumatology.

[2]  Y. Yamaguchi,et al.  Analysis of dermatomyositis‐specific autoantibodies and clinical characteristics in Japanese patients , 2011, The Journal of dermatology.

[3]  H. Tsutsumi,et al.  Anti-CADM-140 Antibody-positive Juvenile Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Cardiac Involvement , 2011, The Journal of Rheumatology.

[4]  M. Fujimoto,et al.  Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study. , 2011, Archives of dermatology.

[5]  C. Oddis,et al.  Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? , 2010, Chest.

[6]  L. Dubertret,et al.  A first case report of a patient with paraneoplastic dermatomyositis developing diffuse alveolar haemorrhage , 2010, The British journal of dermatology.

[7]  N. McHugh,et al.  Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. , 2009, Rheumatology.

[8]  T. Nishikawa,et al.  Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. , 2005, Arthritis and rheumatism.

[9]  V. Cottin,et al.  Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis , 2003, European Respiratory Journal.

[10]  E. Hachulla,et al.  Interstitial lung disease in polymyositis and dermatomyositis. , 2002, Arthritis and rheumatism.

[11]  R. Sontheimer.  Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis siné myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? , 2002, Journal of the American Academy of Dermatology.

[12]  D. Schroeder,et al.  Polymyositis-dermatomyositis-associated interstitial lung disease. , 2001, American journal of respiratory and critical care medicine.

[13]  M. Ishii,et al.  Fatal alveolar hemorrhage in a patient with mixed connective tissue disease presenting polymyositis features. , 1998, Internal medicine.

[14]  J. Nick,et al.  Pulmonary capillaritis and diffuse alveolar hemorrhage. A primary manifestation of polymyositis. , 1995, American journal of respiratory and critical care medicine.