What counters antibiotic resistance in nature?

Antibiotics promote the spread of resistance in the clinic, but various mechanisms may exist in natural environments that tilt the balance toward antibiotic sensitivity. Studying such mechanisms could help us understand the evolutionary dynamics of resistance and sensitivity in the wild, which may inspire new therapeutic strategies.

[1]  D. Bannister Analysis of an R+ strain carrying two fi- sex factors. , 1970, Journal of general microbiology.

[2]  R. Kishony,et al.  A Differential Drug Screen for Compounds That Select Against Antibiotic Resistance , 2010, PloS one.

[3]  D. Hopwood,et al.  Streptomyces in nature and medicine : the antibiotic makers , 2007 .

[4]  C. Fuqua,et al.  Bacterial competition: surviving and thriving in the microbial jungle , 2010, Nature Reviews Microbiology.

[5]  Bernd Schneider,et al.  Symbiotic Streptomycetes provide antibiotic combination prophylaxis for wasp offspring. , 2010, Nature chemical biology.

[6]  Heather K. Allen,et al.  Call of the wild: antibiotic resistance genes in natural environments , 2010, Nature Reviews Microbiology.

[7]  R. Ebright,et al.  Antibiotic Production by Myxobacteria Plays a Role in Predation , 2011, Journal of bacteriology.

[8]  R. Kishony,et al.  Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions , 2009, Cell.

[9]  Roberto Kolter,et al.  New developments in microbial interspecies signaling. , 2009, Current opinion in microbiology.

[10]  Gary Taubes,et al.  The Bacteria Fight Back , 2008, Science.

[11]  B. Ames,et al.  Positive selection for loss of tetracycline resistance , 1980, Journal of bacteriology.

[12]  G. B. Golding,et al.  Antibiotic resistance is ancient , 2011, Nature.

[13]  R. Kishony,et al.  Functional classification of drugs by properties of their pairwise interactions , 2006, Nature Genetics.

[14]  Roy Kishony,et al.  Structure and Evolution of Streptomyces Interaction Networks in Soil and In Silico , 2011, PLoS biology.

[15]  M. Feldman,et al.  Local dispersal promotes biodiversity in a real-life game of rock–paper–scissors , 2002, Nature.

[16]  F. Baquero,et al.  Antibiotics as intermicrobial signaling agents instead of weapons , 2006, Proceedings of the National Academy of Sciences.

[17]  R. Kishony,et al.  Antibiotic interactions that select against resistance , 2007, Nature.

[18]  S. Levy,et al.  Antibacterial resistance worldwide: causes, challenges and responses , 2004, Nature Medicine.

[19]  H. Krapp Ocelli , 2009, Current Biology.

[20]  C. Bacon,et al.  Production of fusaric acid by Fusarium species , 1996, Applied and environmental microbiology.

[21]  B. Craine Novel selection for tetracycline- or chloramphenicol-sensitive Escherichia coli , 1982, Journal of bacteriology.

[22]  R. Kishony,et al.  Chemical decay of an antibiotic inverts selection for resistance , 2010, Nature chemical biology.

[23]  Gerard D. Wright,et al.  Antibiotic resistance in the environment: a link to the clinic? , 2010, Current opinion in microbiology.

[24]  C Reading,et al.  Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus , 1977, Antimicrobial Agents and Chemotherapy.

[25]  W. Szybalski,et al.  GENETIC STUDIES ON MICROBIAL CROSS RESISTANCE TO TOXIC AGENTS I. , , 1952, American review of tuberculosis.