Metabolic Phenotyping in Health and Disease

Analyzing metabolites (small molecules <1 kDa) in body fluids such as urine and plasma using various spectroscopic methods provides information on the metabotype (metabolic phenotype) of individuals or populations, information that can be applied to personalized medicine or public healthcare.

[1]  A. Barabasi,et al.  Human disease classification in the postgenomic era: A complex systems approach to human pathobiology , 2007, Molecular systems biology.

[2]  J. Lindon,et al.  Metabonomics: a platform for studying drug toxicity and gene function , 2002, Nature Reviews Drug Discovery.

[3]  Dominique Gauguier,et al.  Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models , 2007, Nature Genetics.

[4]  S. Horvath,et al.  Variations in DNA elucidate molecular networks that cause disease , 2008, Nature.

[5]  J I Baumbach,et al.  Ion mobility spectrometry in the diagnosis of sarcoidosis: results of a feasibility study. , 2007, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[6]  J. Nicholson Global systems biology, personalized medicine and molecular epidemiology , 2006, Molecular systems biology.

[7]  Leonid Kruglyak,et al.  The road to genome-wide association studies , 2008, Nature Reviews Genetics.

[8]  A. Dyer,et al.  Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. , 2004, JAMA.

[9]  R. Rosenfeld Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[10]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[11]  Richard Barnett Diabetes , 1904, The Lancet.

[12]  J. Castle,et al.  An integrative genomics approach to infer causal associations between gene expression and disease , 2005, Nature Genetics.

[13]  E. Schlatter,et al.  Renal electrolyte effects of guanylin and uroguanylin , 2007, Current opinion in nephrology and hypertension.

[14]  D. Nebert,et al.  Pharmacogenomics and “Individualized Drug Therapy” , 2003 .

[15]  Ian J. Brown,et al.  Human metabolic phenotype diversity and its association with diet and blood pressure , 2008, Nature.

[16]  Haifeng Lu,et al.  Symbiotic gut microbes modulate human metabolic phenotypes , 2008, Proceedings of the National Academy of Sciences.

[17]  F. Hu,et al.  Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population , 2008, Diabetes.

[18]  M. Romero,et al.  Renal physiology of SLC26 anion exchangers , 2007, Current opinion in nephrology and hypertension.

[19]  J. Lindon,et al.  Pharmaco-metabonomic phenotyping and personalized drug treatment , 2006, Nature.