Power Spectral Density Analysis of Electrocorticogram Recordings during Cerebral Hypothermia in Neonatal Seizures

Background: Neonatal seizures (NS) are the most common form of neurological dysfunction observed in newborns. Purpose: The purpose of this study in newborn piglets was to determine the effect of cerebral hypothermia (CH) on neural activity during pharmacologically induced NS. We hypothesized that the neuroprotective effects of CH would preserve higher frequencies observed in electrocorticogram (ECoG) recordings. Methods: Power spectral density was employed to determine the levels of brain activity in ECoGs to quantitatively assess the power of each frequency observed in neurological brain states of delta, theta, alpha, and beta-gamma frequencies. Result: The most significant reduction of power occurs in the lower frequency band of delta-theta-alpha of CH cohorts, while t score probabilities imply that high-frequency brain activity in the beta-gamma range is preserved in the CH population. Conclusion: While the overall power density decreases over time in both groups, the decrease is to a lesser degree in the CH population.

[1]  Robert Kozma,et al.  Seizure prediction through dynamic synchronization measures of neural populations , 2009, 2009 International Joint Conference on Neural Networks.

[2]  Yasuomi D. Sato,et al.  Transitions between multistable states as a model of epileptic seizure dynamics. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[3]  Robert Kozma,et al.  Modeling Dynamics of the Human Limbic System , 2013 .

[4]  J. Kelso,et al.  Toward a Complementary Neuroscience: Metastable Coordination Dynamics of the Brain , 2009 .

[5]  Walter J. Freeman,et al.  Origin, structure, and role of background EEG activity. Part 3. Neural frame classification , 2005, Clinical Neurophysiology.

[6]  C. Stam,et al.  r Human Brain Mapping 32:413–425 (2011) r Network Analysis of Resting State EEG in the Developing Young Brain: Structure Comes With Maturation , 2022 .

[7]  T. Koenig,et al.  Brain electric microstates and momentary conscious mind states as building blocks of spontaneous thinking: I. Visual imagery and abstract thoughts. , 1998, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[8]  J. M. Herrmann,et al.  Dynamical synapses causing self-organized criticality in neural networks , 2007, 0712.1003.

[9]  O. Bertrand,et al.  Oscillatory gamma activity in humans: a possible role for object representation. , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[10]  J. Kelso,et al.  Cortical coordination dynamics and cognition , 2001, Trends in Cognitive Sciences.

[11]  K. Linkenkaer-Hansen,et al.  Long-Range Temporal Correlations and Scaling Behavior in Human Brain Oscillations , 2001, The Journal of Neuroscience.

[12]  Walter J. Freeman,et al.  Petit mal seizure spikes in olfactory bulb and cortex caused by runaway inhibition after exhaustion of excitation , 1986, Brain Research Reviews.

[13]  Tang,et al.  Self-Organized Criticality: An Explanation of 1/f Noise , 2011 .

[14]  Alexander C. Huk,et al.  Neural correlates and neural computations in posterior parietal cortex during perceptual decision-making , 2012, Front. Integr. Neurosci..

[15]  A. Haig,et al.  Synchronous cortical gamma‐band activity in task‐relevant cognition , 2000, Neuroreport.

[16]  W. Freeman.  Origin, structure, and role of background EEG activity. Part 2. Analytic phase , 2004, Clinical Neurophysiology.

[17]  David J. Freedman,et al.  Visual categorization and the parietal cortex , 2012, Front. Integr. Neurosci..

[18]  Sampsa Vanhatalo,et al.  Dynamics of human neocortex that optimizes its stability and flexibility , 2006, Int. J. Intell. Syst..

[19]  M. Raichle,et al.  Cerebellar blood flow and metabolism in cerebral hemisphere infarction , 1983, Annals of neurology.

[20]  T R Gunn,et al.  Neuroprotection With Prolonged Head Cooling Started Before Postischemic Seizures in Fetal Sheep , 1998, Pediatrics.

[21]  M. Raichle.  Behind the scenes of functional brain imaging: a historical and physiological perspective. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  W. Freeman,et al.  Analysis of spatial patterns of phase in neocortical gamma EEGs in rabbit. , 2000, Journal of neurophysiology.

[23]  Elizabeth M. Brannon,et al.  Representation of numerosity in posterior parietal cortex , 2012, Front. Integr. Neurosci..

[24]  D. Levy.  Towards an understanding of parietal mnemonic processes: some conceptual guideposts , 2012, Front. Integr. Neurosci..

[25]  P. Bak,et al.  Complexity, contingency, and criticality. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Walter J. Freeman,et al.  Optimization of olfactory model in software to give 1/f power spectra reveals numerical instabilities in solutions governed by aperiodic (chaotic) attractors , 1998, Neural Networks.

[27]  Dante R. Chialvo,et al.  The brain near the edge , 2006, q-bio/0610041.

[28]  K. Linkenkaer-Hansen,et al.  Avalanche dynamics of human brain oscillations: Relation to critical branching processes and temporal correlations , 2008, Human brain mapping.

[29]  Walter J. Freeman,et al.  Origin, structure, and role of background EEG activity. Part 4: Neural frame simulation , 2006, Clinical Neurophysiology.

[30]  D. Plenz,et al.  The organizing principles of neuronal avalanches: cell assemblies in the cortex? , 2007, Trends in Neurosciences.

[31]  Klaus Linkenkaer-Hansen,et al.  Scale-Free Modulation of Resting-State Neuronal Oscillations Reflects Prolonged Brain Maturation in Humans , 2011, The Journal of Neuroscience.

[32]  Catherine Tallon-Baudry,et al.  The many faces of the gamma band response to complex visual stimuli , 2005, NeuroImage.

[33]  Christopher T. Kello,et al.  Scaling laws in cognitive sciences , 2010, Trends in Cognitive Sciences.

[34]  Robert Kozma,et al.  Modeling normal/epileptic brain dynamics with potential application in titration therapy , 2011, The 2011 International Joint Conference on Neural Networks.