Thyrotropin-induced hyperthyroidism: use of alpha and beta subunit levels to identify patients with pituitary tumors.

Six hyperthyroid patients with inappropriately elevated serum thyrotropin (TSH) had serum concentrations of the common alpha subunit of the glycoprotein hormones (alpha) and the beta subunit of TSH (TSH-β) measured by radioimmunoassay. The three patients with a pituitary tumor had markedly elevated serum alpha levels of 105, 16.6, and 19.5 ng/ml and TSH of 34, 1.7, and 5.6 eU/ml, yielding molar alpha to TSH ratios of 31 to 98; TSH-β was not detected (<;0.5 ng/ml). The three patients without a pituitary tumor had serum alpha concentrations of 1.2, 0.5, and 1.0 ng/ml and serum TSH levels of 160, 9.3, and 90 eU/ml, yielding molar alpha to TSH ratios <1; TSH-β was 1.3, 0.5, and 0.5 ng/ml. Subunit and TSH secretion in the patients with a pituitary tumor demonstrated little or no change after thyrotropin releasing hormone (TRH) or thyroid hormone administration. In contrast, serum subunit and TSH levels increased after TRH in the patients withou a pituitary tumor; both basal and peak subuni and TSH levels after...

[1]  R. Utiger,et al.  Juvenile hyperthyroidism with elevated thyrotropin (TSH) and normal 24 hour FSH, LH, GH and prolactin secretory patterns. , 1977, The Journal of clinical endocrinology and metabolism.

[2]  G. Giustina,et al.  Hyperthyroidism with elevated plasma TSH levels and pituitary tumor: study with somatostatin. , 1976, The Journal of clinical endocrinology and metabolism.

[3]  A. Vermeulen,et al.  Familial partial target organ resistance to thyroid hormones. , 1976, The Journal of clinical endocrinology and metabolism.

[4]  B. Weintraub,et al.  The effect of glucocorticoid administration on human pituitary secretion of thyrotropin and prolactin. , 1976, The Journal of clinical endocrinology and metabolism.

[5]  R. Fahlbusch,et al.  Recurrent goiter, hyperthyroidism, galactorrhea and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. , 1976, The Journal of clinical endocrinology and metabolism.

[6]  B. Weintraub,et al.  Secretion of alpha subunit of glycoprotein hormones by pituitary adenomas. , 1976, The Journal of clinical endocrinology and metabolism.

[7]  B. Weintraub,et al.  THYROTROPIN-INDUCED HYPERTHYROIDISM CAUSED BY SELECTIVE PITUITARY RESISTANCE TO THYROID HORMONE , 1976 .

[8]  P. Baylis.  CASE OF HYPERTHYROIDISM DUE TO A CHROMOPHOBE ADENOMA * , 1976, Clinical endocrinology.

[9]  B. Weintraub,et al.  Pituitary secretion of free alpha and beta subunit of human thyrotropin in patients with thyroid disorders. , 1975, The Journal of clinical endocrinology and metabolism.

[10]  Ross Gt,et al.  Subunits of human glycoprotein hormones. Their immunological and biological behavior. , 1974 .

[11]  P. Snyder,et al.  Effects on the pituitary-thyroid axis and prolactin secretion of single and repetitive oral doses of thyrotropin-releasing hormone (TRH). , 1974, The Journal of clinical endocrinology and metabolism.

[12]  B. Weintraub,et al.  Ectopic production of the isolated alpha subunit of the glycoprotein hormones. A quantitative marker in certain cases of cancer. , 1974, The New England journal of medicine.

[13]  K. Gautvik,et al.  Thyrotropin-releasing hormone is not the sole physiologic mediator of prolactin release during suckling. , 1974, The New England journal of medicine.

[14]  B. Weintraub,et al.  Alpha and beta subunits of human thyrotropin: purification and development of specific radioimmunoassays. , 1974, Endocrinology.

[15]  J. Pierce,et al.  Radioimmunological characterization of human thyrotropin and its subunits: applications for the measurement of human TSH. , 1974, The Journal of clinical endocrinology and metabolism.

[16]  B. Weintraub,et al.  Metabolic clearance and production rates of human thyrotropin. , 1974, The Journal of clinical investigation.

[17]  B. Weintraub,et al.  Ectopic production of the isolated beta subunit of human chorionic gonadotropin. , 1973, The Journal of clinical investigation.

[18]  B. Weintraub,et al.  Increase in the beta subunit of human TSH in hypothyroid serum after thyrotropin releasing hormone. , 1973, The Journal of clinical endocrinology and metabolism.

[19]  B. Weintraub,et al.  Suppression of pituitary TSH secretion in the patient with a hyperfunctioning thyroid nodule. , 1973, The Journal of clinical investigation.

[20]  D. Hadden,et al.  Thyrotoxicosis Recurring after Surgical Removal of a Thyrotrophin-Secreting Pituitary Tumour , 1973, Proceedings of the Royal Society of Medicine.

[21]  B. Lamberg,et al.  Congenital euthyroid goitre and partial peripheral resistance to thyroid hormones. , 1973, Lancet.

[22]  B. Weintraub,et al.  Partial target organ resistance to thyroid hormone. , 1973, The Journal of clinical investigation.

[23]  F. Maloof,et al.  Acromegaly and toxic goiter. Cure of the hyperthyroidism and acromegaly by proton-beam partial hypophysectomy. , 1972, The Journal of clinical endocrinology and metabolism.

[24]  P. Franchimont,et al.  POLYMORPHISM OF PROTEIN AND POLYPEPTIDE HORMONES 1 , 1972, Clinical endocrinology.

[25]  C. Emerson,et al.  Hyperthyroidism and excessive thyrotropin secretion. , 1972, The New England journal of medicine.

[26]  S. Refetoff,et al.  Studies of a sibship with apparent hereditary resistance to the intracellular action of thyroid hormone. , 1972, Metabolism: clinical and experimental.

[27]  P. Beck‐Peccoz,et al.  High plasma thyrotrophin levels in two patients with pituitary tumour. , 1972, Acta endocrinologica.

[28]  J. Pierce.  Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones. , 1971, Endocrinology.

[29]  J. Hershman,et al.  Direct evaluation of pituitary thyrotopin reserve utilizing synthetic thyrotopin releasing hormone. , 1971, The Journal of clinical endocrinology and metabolism.

[30]  F. Maloof,et al.  Hyperthyroidism due to thyrotropin-producing pituitary chromophobe adenoma. , 1970, The New England journal of medicine.

[31]  S. Refetoff,et al.  Familial syndrome combining deaf-mutism, stuppled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone. , 1967, The Journal of clinical endocrinology and metabolism.

[32]  D. Holub,et al.  Remission of Graves' disease following radiotherapy of a pituitary neoplasm. , 1960, The American journal of medicine.

[33]  C. Ezrin,et al.  Pituitary hyperthyroidism. Case report and review of the literature. , 1978, The American journal of medicine.

[34]  R. Sandler.  Recurrent hyperthyroidism in an acromegalic patient previously treated with proton beam irradiation: Graves' disease as probable etiology based on follow-up observations. , 1976, The Journal of clinical endocrinology and metabolism.

[35]  H. Wagner,et al.  Hyperthyreose durch TSH-produzierendes chromophobes Hypophysenadenom , 1972 .

[36]  A. Gordin,et al.  Chromophobe pituitary adenoma with acromegaly and TSH-induced hyperthyroidism associated with parathyroid adenoma. Acromegaly and parathyroid adenoma. , 1969, Acta endocrinologica.

[37]  J. Wilber,et al.  Studies of thyrotropin physiology by means of radioimmunoassay. , 1967, Recent progress in hormone research.