Immunohistological patterns of myeloid antigens: tissue distribution of CD13, CD14, CD16, CD31, CD36, CD65, CD66 and CD67

Summary. A number of differentiation antigens on myeloid cells have been defined on the CD classification system by the four International Workshops on Human Leucocyte Differentiation Antigens. The distribution of eight of these antigens (CD13, CD14, CD16, CD31, CD36, CD65, CD66, CD67) have been studied in human tissues, with the aim of documenting their immunohistological patterns and their degree of myeloid restriction. CD13, the most widely distributed antigen, was found in skin, bile canaliculi, kidney and pancreas. CD14 was not restricted to monocytes and tissue macrophages, being also strongly expressed on dendritic reticulum cells. CD 16 was expressed on granulocytes and tissue macrophages (alveolar and Kupffer cells) and in the red pulp of the spleen. CD31 and CD36 gave a characteristic staining of vascular endothelium, corresponding to their identification as the platelet glycoproteins gp IIa and gp IV. Antibodies against the most recently defined myeloid antigens (CD65, CD66 and CD67) appeared to be more specific for myeloid differentiation than previously described ‘myeloid antigens’.

[1]  E. Reinherz,et al.  A monoclonal antibody reactive with human peripheral blood monocytes. , 1980, Journal of immunology.

[2]  J. Ritz,et al.  Expression of myeloid differentiation antigens on normal and malignant myeloid cells. , 1981, The Journal of clinical investigation.

[3]  V. D’Agati,et al.  Monoclonal anti-human monocyte antibodies OKM1 and OKM5 possess distinctive tissue distributions including differential reactivity with vascular endothelium. , 1984, Journal of immunology.

[4]  H Stein,et al.  Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). , 1984, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[5]  J. Griffin,et al.  A monoclonal antibody reactive with normal and leukemic human myeloid progenitor cells. , 1984, Leukemia research.

[6]  H. Ohto,et al.  A novel leukocyte differentiation antigen: two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts. , 1985, Blood.

[7]  G. Cattoretti,et al.  Immunohistochemical Reactivity of Anti-Myeloid/Stem Cell Workshop Monoclonal Antibodies in Thymus, Lymph Node, Lung, Liver, and Normal Skin , 1986 .

[8]  D. Kraft,et al.  Reactivity Patterns of Monoclonal Antibodies Against Myeloid-Associated Antigens with Human Natural Killer Cells , 1986 .

[9]  J. Barnwell,et al.  Isolation of the thrombospondin membrane receptor. , 1987, The Journal of clinical investigation.

[10]  S. Clarkson,et al.  CD16. Developmentally regulated IgG Fc receptors on cultured human monocytes , 1988, The Journal of experimental medicine.

[11]  G. M. Taylor.  Leucocyte Typing III: White Cell Differentiation Antigens , 1988 .

[12]  V. Desmet,et al.  Plasmacytoid T cells. Immunohistochemical evidence for their monocyte/macrophage origin. , 1988, The American journal of pathology.

[13]  T. Springer,et al.  The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria , 1988, Nature.

[14]  H. Zola,et al.  Further characterization of human myeloid antigens (gp160,95; gp150; gp67): investigation of epitopic heterogeneity and non‐haemopoietic distribution using panels of monoclonal antibodies belonging to CD‐11b, CD‐13 and CD‐33 , 1988, British journal of haematology.

[15]  R. Silverstein,et al.  Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. , 1989, The Journal of clinical investigation.

[16]  G. Freeman,et al.  Isolated human follicular dendritic cells display a unique antigenic phenotype , 1989, The Journal of experimental medicine.

[17]  P. Wernet,et al.  Modulation of monocyte function by cd14 specific monoclonal antibodies in vitro , 1989 .

[18]  B. Perussia,et al.  Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions , 1989, The Journal of experimental medicine.

[19]  E. Macintyre,et al.  Binding of monoclonal antibody to CD16 causes calcium mobilization in large granular lymphocytes but inhibits NK killing. , 1989, Immunology.

[20]  S. H. Lin,et al.  Cloning and expression of a cDNA coding for a rat liver plasma membrane ecto-ATPase. The primary structure of the ecto-ATPase is similar to that of the human biliary glycoprotein I. , 1989, The Journal of biological chemistry.

[21]  Brian Seed,et al.  CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes , 1989, Cell.

[22]  D L Simmons,et al.  Monocyte antigen CD14 is a phospholipid anchored membrane protein. , 1989, Blood.

[23]  S. Oikawa,et al.  Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion. , 1989, Biochemical and biophysical research communications.

[24]  R. Ashmun,et al.  Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. , 1989, The Journal of clinical investigation.

[25]  U. Francke,et al.  CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. , 1990, Journal of immunology.

[26]  P. Möller,et al.  Expression of aminopeptidase N (CD13) in mesenchymal tumors. , 1990, The American journal of pathology.

[27]  C. Power,et al.  Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen , 1990, The Journal of experimental medicine.

[28]  F. Lund-Johansen,et al.  Signal transduction in human monocytes and granulocytes through the PI‐linked antigen CD14 , 1990, FEBS letters.

[29]  F. Maly,et al.  Human monocytes CD36 and CD16 are signaling molecules. Evidence from studies using antibody-induced chemiluminescence as a tool to probe signal transduction. , 1990, Immunology.

[30]  R. Ulevitch,et al.  CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. , 1990, Science.

[31]  J. Gorski,et al.  PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. , 1990, Science.

[32]  J. Fransen,et al.  Intracellular localization of glycosyl-phosphatidylinositol-anchored CD67 and FcRIII (CD16) in affected neutrophil granulocytes of patients with paroxysmal nocturnal hemoglobinuria. , 1991, Blood.

[33]  T. Hoang,et al.  CD66 identifies a neutrophil-specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules. , 1991, Blood.

[34]  C. Ockenhouse,et al.  Adhesive functions of platelets lacking glycoprotein IV (CD36). , 1991, Blood.

[35]  T. Hoang,et al.  CD66 identifies a neutrophil-specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules. , 1991 .

[36]  L. Lanier,et al.  Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation. , 1991, Journal of immunology.

[37]  J. Barnwell,et al.  Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[38]  H. Dockrell.  Leucocyte Typing IV. White Cell Differentiation Antigens , 1991 .

[39]  L. Frati,et al.  GTP-binding proteins transduce signals generated via human FC gamma receptor IIIA (CD16). , 1991, Journal of immunology.

[40]  N. Tandon,et al.  Adhesive functions of platelets lacking glycoprotein IV (CD36) , 1991 .