Exploring the mechanism of MP gel against skin photoaging based on network pharmacology, molecular docking, and experimental validation

Long‐term and high exposure to UV radiation can lead to the development of skin photoaging diseases. Therefore, there is an ongoing need for more natural and safe drugs to prevent or treat skin photoaging diseases.

[1]  D. Ke,et al.  Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking , 2022, Clinical, cosmetic and investigational dermatology.

[2]  A. M. Torres-Contreras,et al.  Plant Secondary Metabolites against Skin Photodamage: Mexican Plants, a Potential Source of UV-Radiation Protectant Molecules , 2022, Plants.

[3]  Yunfei Xie,et al.  Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil , 2021, Bioengineered.

[4]  Tong Chen,et al.  EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks online. , 2021, Journal of genetics and genomics = Yi chuan xue bao.

[5]  M. Won,et al.  Chemical Composition of a Novel Distillate from Fermented Mixture of Nine Anti-Inflammatory Herbs and Its UVB-Protective Efficacy in Mouse Dorsal Skin via Attenuating Collagen Disruption and Inflammation , 2020, Molecules.

[6]  W. Kuo,et al.  Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts , 2020, Environmental toxicology.

[7]  W. Kuo,et al.  Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosinase pathway , 2020, Environmental toxicology.

[8]  Xinyuan Shi,et al.  Multiscale study on the enhancing effect and mechanism of borneolum on transdermal permeation of drugs with different log P values and molecular sizes. , 2020, International journal of pharmaceutics.

[9]  Ying Zhang,et al.  Biomarkers, oxidative stress and autophagy in skin aging , 2020, Ageing Research Reviews.

[10]  Xiaoxv Dong,et al.  Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review , 2020, Pharmaceutical biology.

[11]  Xue Xiao,et al.  Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective , 2020, Chinese journal of integrative medicine.

[12]  Sungwoo Kim,et al.  Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression , 2019, International journal of molecular sciences.

[13]  Jingwei Tian,et al.  Preclinical safety of ginsenoside compound K: Acute, and 26-week oral toxicity studies in mice and rats. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[14]  Sang-hyun Ahn,et al.  Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[15]  A. L. Kadekaro,et al.  Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation , 2018, Front. Pharmacol..

[16]  M. Cavinato,et al.  Plant extracts and natural compounds used against UVB-induced photoaging , 2017, Biogerontology.

[17]  C. Menck,et al.  Sunlight damage to cellular DNA: Focus on oxidatively generated lesions. , 2017, Free radical biology & medicine.

[18]  Douglas E. Vaughan,et al.  Molecular and physiological manifestations and measurement of aging in humans , 2017, Aging cell.

[19]  E. Lephart.  Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms , 2016, Ageing Research Reviews.

[20]  Yuhong Liu,et al.  Photo-protective activity of pogostone against UV-induced skin premature aging in mice , 2016, Experimental Gerontology.

[21]  D. Trisciuoglio,et al.  Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies , 2016, Aging.

[22]  U. Babu,et al.  Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f. , 2016, Natural product research.

[23]  Jae Min Han,et al.  Topical Application of Angelica sinensis Improves Pruritus and Skin Inflammation in Mice with Atopic Dermatitis-Like Symptoms. , 2016, Journal of medicinal food.

[24]  M. Jia,et al.  Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties. , 2015, The American journal of Chinese medicine.

[25]  D. Leavesley,et al.  Shikonin reduces TGF-β1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts , 2015, International journal of molecular medicine.

[26]  R. Luiten,et al.  Oxidation events and skin aging , 2015, Ageing Research Reviews.

[27]  Z. Su,et al.  The protective effect of 18β-Glycyrrhetinic acid against UV irradiation induced photoaging in mice , 2015, Experimental Gerontology.

[28]  N. Gibbs,et al.  Damage to skin extracellular matrix induced by UV exposure. , 2014, Antioxidants & redox signaling.

[29]  Rongfeng Lin,et al.  Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil. , 2014, Journal of ethnopharmacology.

[30]  Y. Kimura,et al.  Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice , 2009, Journal of Natural Medicines.

[31]  T. Fan,et al.  Caspase family proteases and apoptosis. , 2005, Acta biochimica et biophysica Sinica.

[32]  C. Oresajo,et al.  Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation‐induced matrix degradation – a review , 2005, International journal of cosmetic science.

[33]  Yukihiko Hara,et al.  Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. , 2004, The Journal of investigative dermatology.

[34]  J. Voorhees,et al.  Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin. , 2004, The Journal of investigative dermatology.

[35]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[36]  K. Scharffetter-Kochanek,et al.  Solar UV irradiation and dermal photoaging. , 2001, Journal of photochemistry and photobiology. B, Biology.

[37]  K. Scharffetter-Kochanek,et al.  Photoaging of the skin from phenotype to mechanisms , 2000, Experimental Gerontology.

[38]  S. D. du Plessis,et al.  Ultraviolet Light Induced Generation of Reactive Oxygen Species. , 2017, Advances in experimental medicine and biology.

[39]  Xu Jin-bo.  Anti-aging effects of Arnebia euchroma(Royle) Johnston extracts in subacute aging mice caused by D-galactose , 2009 .

[40]  Yang Zhi-rong.  Ultraviole induced formation mechanism of photoaging , 2009 .