Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors

[1]  Kitodo Praxistreffen,et al.  Phase I , 2019, Encyclopedic Dictionary of Archaeology.

[2]  V. Schini-Kerth,et al.  Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells , 2017, Cell Biology and Toxicology.

[3]  N. Sojic,et al.  Co(iii) complexes of (1,3-selenazol-2-yl)hydrazones and their sulphur analogues. , 2017, Dalton transactions.

[4]  S. Radulović,et al.  (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. , 2017, MedChemComm.

[5]  D. Richardson,et al.  Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes. , 2016, Journal of inorganic biochemistry.

[6]  R. Silvestri,et al.  Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines , 2016 .

[7]  J. Thiery,et al.  Exosome-Mediated Metastasis: From Epithelial-Mesenchymal Transition to Escape from Immunosurveillance. , 2016, Trends in pharmacological sciences.

[8]  W. Berger,et al.  Differences in protein binding and excretion of Triapine and its Fe(III) complex. , 2016, Journal of inorganic biochemistry.

[9]  W. Berger,et al.  Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention , 2016, Journal of medicinal chemistry.

[10]  Lewis H. Mervin,et al.  Trisubstituted-Imidazoles Induce Apoptosis in Human Breast Cancer Cells by Targeting the Oncogenic PI3K/Akt/mTOR Signaling Pathway , 2016, PloS one.

[11]  E. Ratner,et al.  Triapine potentiates platinum-based combination therapy by disruption of homologous recombination repair , 2016, British Journal of Cancer.

[12]  C. Myers Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase. , 2016, Free radical biology & medicine.

[13]  Ø. Bruserud,et al.  Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia , 2016, Oncotarget.

[14]  D. Richardson,et al.  Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. , 2016, Journal of medicinal chemistry.

[15]  C. Muller,et al.  Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and -9 independent apoptose induction , 2015 .

[16]  Marius Raica,et al.  The Story of MCF-7 Breast Cancer Cell Line: 40 years of Experience in Research. , 2015, Anticancer research.

[17]  F. Fontanesi,et al.  Mitochondria: Structure and Role in Respiration , 2015 .

[18]  Xiangrong Li,et al.  Interaction of oridonin with human serum albumin by isothermal titration calorimetry and spectroscopic techniques. , 2015, Chemico-biological interactions.

[19]  J. Fernández-Bolaños,et al.  Phenolic thio- and selenosemicarbazones as multi-target drugs. , 2015, European journal of medicinal chemistry.

[20]  Julia L. Brumaghim,et al.  Sulfur and selenium antioxidants: challenging radical scavenging mechanisms and developing structure-activity relationships based on metal binding. , 2015, Journal of inorganic biochemistry.

[21]  G. Combs Biomarkers of Selenium Status , 2015, Nutrients.

[22]  R. Lange,et al.  Live Fluorescent RNA‐Based Detection of Pluripotency Gene Expression in Embryonic and Induced Pluripotent Stem Cells of Different Species , 2015, Stem cells.

[23]  E. Ratner,et al.  Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. , 2014, Biochemical pharmacology.

[24]  I. Matić,et al.  Steroid dimers—In vitro cytotoxic and antimicrobial activities , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[25]  M. Pollak,et al.  Metformin directly acts on mitochondria to alter cellular bioenergetics , 2014, Cancer & metabolism.

[26]  N. Polović,et al.  Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes , 2014, Monatshefte für Chemie - Chemical Monthly.

[27]  Anders Ståhlberg,et al.  The workflow of single-cell expression profiling using quantitative real-time PCR , 2014, Expert review of molecular diagnostics.

[28]  Huan Qi,et al.  Interaction of Warfarin with Human Serum Albumin and Effect of Ferulic Acid on the Binding , 2014 .

[29]  David Robert Grimes,et al.  A method for estimating the oxygen consumption rate in multicellular tumour spheroids , 2014, Journal of The Royal Society Interface.

[30]  W. Berger,et al.  Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells , 2014, Molecular Pharmacology.

[31]  Hong Liang,et al.  Interactive Association of Drugs Binding to Human Serum Albumin , 2014, International journal of molecular sciences.

[32]  B. Evans,et al.  SOD2 to SOD1 Switch in Breast Cancer* , 2014, The Journal of Biological Chemistry.

[33]  E. Ratner,et al.  Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors , 2014, Molecular Cancer Research.

[34]  J. Rose,et al.  Structural studies of several clinically important oncology drugs in complex with human serum albumin. , 2013, Biochimica et biophysica acta.

[35]  P. Fernandes,et al.  Development of ribonucleotide reductase inhibitors: a review on structure activity relationships. , 2013, Mini reviews in medicinal chemistry.

[36]  Elias S. J. Arnér,et al.  Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. , 2013, Free radical biology & medicine.

[37]  M. Grever,et al.  A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors , 2013, Investigational New Drugs.

[38]  Anders Ståhlberg,et al.  The added value of single-cell gene expression profiling. , 2013, Briefings in functional genomics.

[39]  D. Richardson,et al.  Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation. , 2013, Journal of medicinal chemistry.

[40]  J. Stubbe,et al.  Mechanistic Studies of Semicarbazone Triapine Targeting Human Ribonucleotide Reductase in Vitro and in Mammalian Cells , 2012, The Journal of Biological Chemistry.

[41]  D. Richardson,et al.  Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect , 2012, Molecular Pharmacology.

[42]  C. Pirker,et al.  Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones , 2012, Biochemical pharmacology.

[43]  P. Wipf,et al.  Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi , 2012 .

[44]  W. Berger,et al.  Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds , 2012, JBIC Journal of Biological Inorganic Chemistry.

[45]  C. Hoppel,et al.  Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia. , 2012, Future oncology.

[46]  E. Stratulat,et al.  Synthesis, antibacterial, and antifungal activities of 8-quinolinealdehyde chalcogensemicarbazones and their copper(II) complexes , 2011, Pharmaceutical Chemistry Journal.

[47]  P. Chiba,et al.  Synthesis, structures and anti-malaria activity of some gold(I) phosphine complexes containing seleno- and thiosemicarbazonato ligands. , 2011, Dalton transactions.

[48]  M. Ushio-Fukai,et al.  Superoxide dismutases: role in redox signaling, vascular function, and diseases. , 2011, Antioxidants & redox signaling.

[49]  E. Lander,et al.  Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells , 2011, Cell.

[50]  R. Xiang,et al.  Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. , 2011, Biochemical and biophysical research communications.

[51]  B. Keppler,et al.  Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study. , 2011, Dalton Transactions.

[52]  Jeong-Seok Nam,et al.  OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer , 2011, Laboratory animal research.

[53]  Erin E. Battin,et al.  Preventing metal-mediated oxidative DNA damage with selenium compounds. , 2011, Metallomics : integrated biometal science.

[54]  P. Pandolfi,et al.  SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. , 2011, Cancer cell.

[55]  W. Antholine,et al.  The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress. , 2011, Toxicology letters.

[56]  S. Park,et al.  Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. , 2010, Molecular cell.

[57]  B. Han,et al.  Prognostic significance of OCT4 expression in adenocarcinoma of the lung. , 2010, Japanese journal of clinical oncology.

[58]  Zhiwei Wang,et al.  Epithelial to Mesenchymal Transition Is Mechanistically Linked with Stem Cell Signatures in Prostate Cancer Cells , 2010, PloS one.

[59]  P. Lu,et al.  Octamer 4 (Oct4) mediates chemotherapeutic drug resistance in liver cancer cells through a potential Oct4–AKT–ATP‐binding cassette G2 pathway , 2010, Hepatology.

[60]  B. Keppler,et al.  Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3‐Aminopyridine‐2‐carbaldehyde Thiosemicarbazone) and Related Ligands , 2010 .

[61]  Y. Xu,et al.  A common gain of function of p53 cancer mutants in inducing genetic instability , 2010, Oncogene.

[62]  T. Kinsella,et al.  Phase I Trial of Pelvic Radiation, Weekly Cisplatin, and 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone (3-AP, NSC #663249) for Locally Advanced Cervical Cancer , 2010, Clinical Cancer Research.

[63]  E. Morselli,et al.  Mitochondrial gateways to cancer. , 2010, Molecular aspects of medicine.

[64]  I. Lichtscheidl,et al.  Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex. , 2010, Dalton transactions.

[65]  David S. Goodsell,et al.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility , 2009, J. Comput. Chem..

[66]  Y. Toiyama,et al.  Correlation of CD133, OCT4, and SOX2 in Rectal Cancer and Their Association with Distant Recurrence After Chemoradiotherapy , 2009, Annals of Surgical Oncology.

[67]  A. Bacchi,et al.  Synthesis, characterization and biological activity evaluation of Pt(II), Pd(II), Co(III) and Ni(II) complexes with N -heteroaromatic selenosemicarbazones , 2009 .

[68]  W. Berger,et al.  Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation. , 2009, Journal of medicinal chemistry.

[69]  Arthur J. Olson,et al.  AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading , 2009, J. Comput. Chem..

[70]  G. Wilding,et al.  A phase I study of Triapine® in combination with doxorubicin in patients with advanced solid tumors , 2009, Cancer Chemotherapy and Pharmacology.

[71]  R. Schmid,et al.  OCT4 expression in human non-small cell lung cancer: implications for therapeutic intervention. , 2009, Interactive cardiovascular and thoracic surgery.

[72]  S. Ménard,et al.  Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab , 2009, Clinical Cancer Research.

[73]  M. Galanski,et al.  An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones. , 2008, Inorganic chemistry.

[74]  Hwan-You Chang,et al.  Recent advances in three‐dimensional multicellular spheroid culture for biomedical research , 2008, Biotechnology journal.

[75]  G. Shaw,et al.  Brine shrimp bioassay: Importance of correct taxonomic identification of Artemia (Anostraca) species , 2008, Environmental toxicology.

[76]  B. Goh,et al.  A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells , 2008, Investigational New Drugs.

[77]  Nektarios Tavernarakis,et al.  No death without life: vital functions of apoptotic effectors , 2008, Cell Death and Differentiation.

[78]  J. Marley,et al.  Prilocaine induced methaemoglobinaemia in a medically compromised patient. Was this an inevitable consequence of the dose administered? , 2007, BDJ.

[79]  V. Baladandayuthapani,et al.  Targeting cell signaling pathways for drug discovery: An old lock needs a new key , 2007, Journal of cellular biochemistry.

[80]  E. Eisenhauer,et al.  Phase II study of Triapine® in patients with metastatic renal cell carcinoma: a trial of the National Cancer Institute of Canada Clinical Trials Group (NCIC IND.161) , 2007, Investigational New Drugs.

[81]  D. Richardson,et al.  Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond , 2006, Clinical Cancer Research.

[82]  Stefan Grimme,et al.  Semiempirical GGA‐type density functional constructed with a long‐range dispersion correction , 2006, J. Comput. Chem..

[83]  D. Richardson,et al.  A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics , 2006, Proceedings of the National Academy of Sciences.

[84]  L. Wiesmüller,et al.  p53 in recombination and repair , 2006, Cell Death and Differentiation.

[85]  K. Camphausen,et al.  In vitro and In vivo Radiosensitization Induced by the Ribonucleotide Reductase Inhibitor Triapine (3-Aminopyridine-2-Carboxaldehyde-Thiosemicarbazone) , 2006, Clinical Cancer Research.

[86]  Y. Yen,et al.  A Ferrous-triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase , 2006, Molecular Cancer Therapeutics.

[87]  Brian Keith,et al.  HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. , 2006, Genes & development.

[88]  G. Mor,et al.  Triapine (3-aninopyridine-2-carboxaldehyde thiosemicarbazone) Induces Apoptosis in Ovarian Cancer Cells , 2006, The Journal of the Society for Gynecologic Investigation: JSGI.

[89]  D. Richardson,et al.  The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer , 2005, Pharmacological Reviews.

[90]  S. Curry,et al.  Structural basis of the drug-binding specificity of human serum albumin. , 2005, Journal of molecular biology.

[91]  C. Galmarini,et al.  Increased expression of the large subunit of ribonucleotide reductase is involved in resistance to gemcitabine in human mammary adenocarcinoma cells , 2005, Molecular Cancer Therapeutics.

[92]  R. Prior,et al.  Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements. , 2005, Journal of agricultural and food chemistry.

[93]  Y. Saintigny,et al.  p53's double life: transactivation-independent repression of homologous recombination. , 2004, Trends in genetics : TIG.

[94]  M. Sznol,et al.  Phase I and pharmacokinetic study of the ribonucleotide reductase inhibitor, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, administered by 96-hour intravenous continuous infusion. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[95]  Y. Ikawa,et al.  Dimerization and Processing of Procaspase-9 by Redox Stress in Mitochondria* , 2004, Journal of Biological Chemistry.

[96]  Yate-Ching Yuan,et al.  In Vitro Characterization of Enzymatic Properties and Inhibition of the p53R2 Subunit of Human Ribonucleotide Reductase , 2004, Cancer Research.

[97]  R. Weissleder,et al.  The transferrin receptor: a potential molecular imaging marker for human cancer. , 2003, Neoplasia.

[98]  C. Reynolds,et al.  Hypoxia-targeting copper bis(selenosemicarbazone) complexes: comparison with their sulfur analogues. , 2003, Journal of the American Chemical Society.

[99]  J. Ohnishi,et al.  ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation. , 2003, Experimental cell research.

[100]  M. Temperini,et al.  2-Formylpyridinethiosemicarbazone and methyl derivatives: spectroscopic studies , 2001 .

[101]  S. Krauss Mitochondria: Structure and Role in Respiration , 2001 .

[102]  G. Thomas,et al.  Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shortening. , 2001, Biochemical and biophysical research communications.

[103]  A. Sartorelli,et al.  Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity. , 2000, Biochemical pharmacology.

[104]  A. Sartorelli,et al.  Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. , 1999, Advances in enzyme regulation.

[105]  M F Sanner,et al.  Python: a programming language for software integration and development. , 1999, Journal of molecular graphics & modelling.

[106]  P. Brick,et al.  Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites , 1998, Nature Structural Biology.

[107]  C. Niu,et al.  Synthesis of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) , 1998 .

[108]  S. Powell,et al.  Inactivation of p53 results in high rates of homologous recombination , 1997, Oncogene.

[109]  A. Sartorelli,et al.  Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. , 1996, Journal of medicinal chemistry.

[110]  A. Sartorelli,et al.  Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones. , 1994, Biochemical pharmacology.

[111]  A. Sartorelli,et al.  Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. , 1992, Journal of medicinal chemistry.

[112]  D. Carter,et al.  Atomic structure and chemistry of human serum albumin , 1992, Nature.

[113]  R. K. Robins,et al.  Chemotherapeutic characterization in mice of 2-amino-9-beta-D-ribofuranosylpurine-6-sulfinamide (sulfinosine), a novel purine nucleoside with unique antitumor properties. , 1990, Cancer research.

[114]  J. Drach,et al.  Structure-activity relationships among alpha-(N)-heterocyclic acyl thiosemicarbazones and related compounds as inhibitors of herpes simplex virus type 1-specified ribonucleoside diphosphate reductase. , 1986, The Journal of general virology.

[115]  R. Walker,et al.  Transferrin receptor expression in non‐malignant and malignant human breast tissue , 1986, The Journal of pathology.

[116]  L. Pannell,et al.  Iron(III) complexes of some thiosemicarbazones derived from 2-acetylpyridine, its 6-methyl derivative and itsN-oxide , 1985 .

[117]  D. L. Klayman,et al.  2-Acetylpyridine thiosemicarbazones. 6.2-Acetylpyridine and 2-butyrylpyridine thiosemicarbazones as antileukemic agents. , 1983, Arzneimittel-Forschung.

[118]  D. E. Nichols,et al.  Brine shrimp: a convenient general bioassay for active plant constituents. , 1982, Planta medica.

[119]  P. Sorgeloos,et al.  Proposal for a short-term toxicity test with Artemia nauplii. , 1981, Ecotoxicology and environmental safety.

[120]  P. Ross,et al.  Thermodynamics of protein association reactions: forces contributing to stability. , 1981, Biochemistry.

[121]  A. D. McLean,et al.  Contracted Gaussian basis sets for molecular calculations. I. Second row atoms, Z=11–18 , 1980 .

[122]  N. Doorenbos,et al.  Screening procedure for phorbol esters using brine shrimp (Artemia salina) larvae. , 1977, Journal of pharmaceutical sciences.

[123]  R. Carrell,et al.  Oxidation of human haemoglobin by copper. Mechanism and suggested role of the thiol group of residue beta-93. , 1977, Biochemical Journal.

[124]  A. Sartorelli,et al.  Comparative studies of the antineoplastic activity of 5-hydroxy-2-formylpyridine thiosemicarbazone and its seleno-semicarbazone, guanylhydrazone and semicarbazone analogs. , 1974, Biochemical pharmacology.

[125]  R. W. Brockman,et al.  Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity. , 1974, Journal of medicinal chemistry.

[126]  J. Bertino,et al.  Clinical and pharmacological studies with 5-hydroxy-2-formylpyridine thiosemicarbazone. , 1972, Cancer research.

[127]  D. Grosch Poisonig with DDT: Effect on Reproductive Performance of Artemia , 1967, Science.

[128]  P. Mitchell,et al.  Evidence discriminating between the Chemical and the Chemiosmotic Mechanisms of Electron Transport Phosphorylation , 1965, Nature.

[129]  PETER MITCHELL,et al.  Stoichiometry of Proton Translocation through the Respiratory Chain and Adenosine Triphosphatase Systems of Rat Liver Mitochondria , 1965, Nature.

[130]  A. B. Robinson,et al.  Anesthesia of Artemia Larvae: Method for Quantitative Study , 1965, Science.

[131]  Xuehao Wang,et al.  OCT4 regulates epithelial-mesenchymal transition and its knockdown inhibits colorectal cancer cell migration and invasion. , 2013, Oncology reports.

[132]  三枝 晋 Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy , 2012 .

[133]  M. Sznol,et al.  A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloproliferative disorders. , 2008, Leukemia research.

[134]  Lorenzo Galluzzi,et al.  Mitochondrial membrane permeabilization in cell death. , 2007, Physiological reviews.

[135]  Pär Nordlund,et al.  Ribonucleotide reductases. , 2006, Annual review of biochemistry.

[136]  A. Goldstein,et al.  The effects of morphine-like compounds on the light responses of the brine shrimp Artemia salina , 2004, Psychopharmacologia.

[137]  A. Sartorelli,et al.  Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo. , 1995, Advances in enzyme regulation.

[138]  W. R. Wadt,et al.  Ab initio effective core potentials for molecular calculations , 1984 .

[139]  J. Lakowicz Principles of fluorescence spectroscopy , 1983 .

[140]  J. Pople,et al.  Self‐consistent molecular orbital methods. XX. A basis set for correlated wave functions , 1980 .

[141]  H. Schaefer Methods of Electronic Structure Theory , 1977 .

[142]  T. Edition,et al.  The determination of ionization constants , 1971 .

[143]  H. Mautner,et al.  Antifungal activity of some substituted selenosemicarbazones and related compounds. , 1956, Antibiotics & chemotherapy.