Neuron-specific enolase A probe for neurons and neuroendocrine cells

Abstract Three forms of the glycolytic enzyme enolase exist in brain representing three possible dimeric combinations of two distinct α and γ subunits. Neuron-specific enolase (NSE) is composed of two γ subunits and is found only in neurons and neuroendocrine cells. A non-neuronal enolase composed of two α subunits is found in glia. The γ subunit is also a useful marker for neuroendocrine peptide-containing cells of the APUD (amine precursor uptake and decarboxylation) classification and is present in relatively high amounts in APUDomas. The ability to quantitate and visualize NSE should therefore prove useful to a variety of disciplines in neurobiology and neuroendocrinology.

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