Spatial summation of S-cone ON and OFF signals: Effects of retinal eccentricity

We studied spatial summation for S-cone ON and OFF signals as a function of retinal eccentricity in human subjects. S-cone isolation was obtained by the two-colour threshold method of Stiles, modified by adding blue light to the yellow background. Test stimuli were blue light increments or decrements within a circular area of variable size. These were presented for 100 ms at 0 to 20 deg along the horizontal temporal retinal meridian. Ricco's area of complete spatial summation was measured from the threshold vs. area curves. This was nearly constant and approximately the same for both types of stimuli within the 0-5 deg range and increased beyond this range. The decremental area increased faster, suggesting that separate mechanisms, presumably ON and OFF, integrate S-cone increments and decrements. The results appear to provide new evidence for the existence of separate S-cone ON and OFF pathways. We compare the data with known morphology of primate retina and assume that, if S-cone decrements are detected via separate OFF cells, these should differ in density and dendritic field size from the S-cone ON cells, but only in the retinal periphery.

[1]  N Drasdo,et al.  Non-linear projection of the retinal image in a wide-angle schematic eye. , 1974, The British journal of ophthalmology.

[2]  H. Wässle,et al.  The structural correlate of the receptive field centre of alpha ganglion cells in the cat retina. , 1983, The Journal of physiology.

[3]  A. Milam,et al.  Distribution and morphology of human cone photoreceptors stained with anti‐blue opsin , 1991, The Journal of comparative neurology.

[4]  H. Barlow.  Temporal and spatial summation in human vision at different background intensities , 1958, The Journal of physiology.

[5]  D. Dacey.  Morphology of a small-field bistratified ganglion cell type in the macaque and human retina , 1993, Visual Neuroscience.

[6]  William R. Mathew,et al.  Color as a Science , 2005 .

[7]  V C Smith,et al.  Temporal modulation sensitivity and pulse-detection thresholds for chromatic and luminance perturbations. , 1987, Journal of the Optical Society of America. A, Optics and image science.

[8]  Peter H. Schiller,et al.  Lack of blue OFF-center cells in the visual system of the monkey , 1978, Brain Research.

[9]  B. B. Lee,et al.  Receptive field structure in the primate retina , 1996, Vision Research.

[10]  J. Pokorny,et al.  Effect of sawtooth polarity on chromatic and luminance detection , 1994, Visual Neuroscience.

[11]  Shaban Demirel,et al.  What limits detection and resolution of short-wavelength sinusoidal gratings across the retina? , 2002, Vision Research.

[12]  David R. Williams,et al.  Punctate sensitivity of the blue-sensitive mechanism , 1981, Vision Research.

[13]  R W Jones,et al.  Increment and decrement visual thresholds. , 1968, Journal of the Optical Society of America.

[14]  J. Mollon,et al.  A theory of theΠ1 andΠ3 color mechanisms of stiles , 1979, Vision Research.

[15]  A. Vassilev,et al.  Spatial summation of blue-on-yellow light increments and decrements in human vision , 2000, Vision Research.

[16]  P. Lennie,et al.  Chromatic mechanisms in lateral geniculate nucleus of macaque. , 1984, The Journal of physiology.

[17]  John S. Werner,et al.  Spatial summation in human cone mechanisms from 0° to 20° in the superior retina , 2000 .

[18]  B. Boycott,et al.  Functional architecture of the mammalian retina. , 1991, Physiological reviews.

[19]  D. Dacey,et al.  Identification of an S-cone Opponent OFF Pathway in the Macaque Monkey Retina: Morphology, Physiology and Possible Circuitry , 2002 .

[20]  Barry B. Lee,et al.  The 'blue-on' opponent pathway in primate retina originates from a distinct bistratified ganglion cell type , 1994, Nature.

[21]  John Krauskopf,et al.  Discrimination and detection of changes in luminance , 1980, Vision Research.

[22]  F. D. de Monasterio.  Asymmetry of on- and off-pathways of blue-sensitive cones of the retina of macaques. , 1979, Brain research.

[23]  G. C. Duncan,et al.  Contribution of the retinal ON channels to scotopic and photopic spectral sensitivity , 1989, Visual Neuroscience.

[24]  R. M. Boynton,et al.  Temporal modulation sensitivity of the blue mechanism: Measurements made without chromatic adaptation , 1980, Vision Research.

[25]  R. L. Valois,et al.  Some transformations of color information from lateral geniculate nucleus to striate cortex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Rhea T Eskew,et al.  ON and OFF S-cone pathways have different long-wave cone inputs , 2000, Vision Research.

[27]  S. Schwartz.  Spectral sensitivity as revealed by isolated step onsets and step offsets. , 1996, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[28]  D. W. Heeley,et al.  Cardinal directions of color space , 1982, Vision Research.

[29]  Paul R. Martin,et al.  Colour processing in the primate retina: recent progress , 1998, The Journal of physiology.

[30]  R. Bogartz,et al.  A least squares method for fitting intercepting line segments to a set of data points. , 1968 .

[31]  Paul D. Gamlin,et al.  Fireworks in the Primate Retina In Vitro Photodynamics Reveals Diverse LGN-Projecting Ganglion Cell Types , 2003, Neuron.