Notch signalling: a simple pathway becomes complex

[1]  David Newnham,et al.  Outside in. , 2008, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[2]  Henry C. Chang,et al.  Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway , 2006, The Journal of cell biology.

[3]  Sally Lowell,et al.  Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells , 2006, PLoS biology.

[4]  A. Chitnis.  Why is delta endocytosis required for effective activation of notch? , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[5]  Julian Lewis,et al.  Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear , 2006, Development.

[6]  D. Dorsett,et al.  Nipped-A, the Tra1/TRRAP Subunit of the Drosophila SAGA and Tip60 Complexes, Has Multiple Roles in Notch Signaling during Wing Development , 2006, Molecular and Cellular Biology.

[7]  Jon C. Aster,et al.  Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes , 2006, Cell.

[8]  Rhett A. Kovall,et al.  Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA , 2006, Cell.

[9]  M. Milán,et al.  Self‐refinement of Notch activity through the transmembrane protein Crumbs: modulation of γ‐Secretase activity , 2006, EMBO reports.

[10]  G. Stormo,et al.  Target Selectivity of Vertebrate Notch Proteins , 2006, Journal of Biological Chemistry.

[11]  Min Gao,et al.  Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[12]  F. Schweisguth,et al.  Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. , 2006, Developmental cell.

[13]  Eric Wieschaus,et al.  Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. , 2006, Developmental cell.

[14]  Angeliki Louvi,et al.  Notch signalling in vertebrate neural development , 2006, Nature Reviews Neuroscience.

[15]  A. Spradling,et al.  The adult Drosophila posterior midgut is maintained by pluripotent stem cells , 2006, Nature.

[16]  N. Perrimon,et al.  Evidence that stem cells reside in the adult Drosophila midgut epithelium , 2006, Nature.

[17]  J. Bolívar,et al.  Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing , 2006, Nature.

[18]  T. Klein,et al.  Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. , 2006, Developmental biology.

[19]  D. Maier,et al.  Hairless-Mediated Repression of Notch Target Genes Requires the Combined Activity of Groucho and CtBP Corepressors , 2005, Molecular and Cellular Biology.

[20]  A. Bauer,et al.  Regulation of Notch signalling by non-visual β-arrestin , 2005, Nature Cell Biology.

[21]  F. Oswald,et al.  RBP-Jκ/SHARP Recruits CtIP/CtBP Corepressors To Silence Notch Target Genes , 2005, Molecular and Cellular Biology.

[22]  Iva Greenwald,et al.  LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans , 2005, Development.

[23]  S. Cohen,et al.  Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. , 2005, Developmental cell.

[24]  D. Bilder,et al.  The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. , 2005, Developmental cell.

[25]  S. Jarriault,et al.  Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE. , 2005, Developmental biology.

[26]  J. Aster.  Deregulated NOTCH Signaling in Acute T-Cell Lymphoblastic Leukemia/Lymphoma: New Insights, Questions, and Opportunities , 2005, International journal of hematology.

[27]  I. Hariharan,et al.  Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. , 2005, Developmental cell.

[28]  D. Bilder,et al.  Endocytic control of epithelial polarity and proliferation in Drosophila , 2005, Nature Cell Biology.

[29]  C. Delidakis,et al.  The interplay between DSL proteins and ubiquitin ligases in Notch signaling , 2005, Development.

[30]  D. Berdnik,et al.  Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System , 2005, Cell.

[31]  Sunil Q. Mehta,et al.  Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. , 2005, Developmental cell.

[32]  J. Knoblich,et al.  Numb and α‐Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs , 2005, EMBO reports.

[33]  Scott Barolo,et al.  Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless , 2005, Development.

[34]  C. Doe,et al.  Genetic Screens for Enhancers of brahma Reveal Functional Interactions Between the BRM Chromatin-Remodeling Complex and the Delta-Notch Signal Transduction Pathway in Drosophila , 2005, Genetics.

[35]  A. Fraser,et al.  Chromatin regulation and sumoylation in the inhibition of Ras‐induced vulval development in Caenorhabditis elegans , 2005, The EMBO journal.

[36]  M. Pelto-huikko,et al.  Shedding light on ADAM metalloproteinases. , 2005, Trends in biochemical sciences.

[37]  Hans Clevers,et al.  Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells , 2005, Nature.

[38]  S. Artavanis-Tsakonas,et al.  Notch signals control the fate of immature progenitor cells in the intestine , 2005, Nature.

[39]  G. Struhl,et al.  Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila , 2005, Development.

[40]  J. Priess,et al.  The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways. , 2005, Developmental cell.

[41]  M. Gho,et al.  Lethal Giant Larvae Controls the Localization of Notch-Signaling Regulators Numb, Neuralized, and Sanpodo in Drosophila Sensory-Organ Precursor Cells , 2005, Current Biology.

[42]  G. Rubin,et al.  The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta , 2005, Development.

[43]  Gerald M Rubin,et al.  Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. , 2005, Genes & development.

[44]  W. Zhong,et al.  Numb Proteins Specify Asymmetric Cell Fates via an Endocytosis- and Proteasome-Independent Pathway , 2005, Molecular and Cellular Biology.

[45]  F. Schweisguth,et al.  The roles of receptor and ligand endocytosis in regulating Notch signaling , 2005, Development.

[46]  F. Schweisguth,et al.  Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila , 2005, PLoS biology.

[47]  A. Xu,et al.  Chaperone Activity of Protein O-Fucosyltransferase 1 Promotes Notch Receptor Folding , 2005, Science.

[48]  M. Bienz,et al.  Bre1 is required for Notch signaling and histone modification. , 2005, Developmental cell.

[49]  M. Caudy,et al.  A DNA Transcription Code for Cell-Specific Gene Activation by Notch Signaling , 2005, Current Biology.

[50]  B. Shilo,et al.  Unidirectional Notch signaling depends on continuous cleavage of Delta , 2004, Development.

[51]  G. Weinmaster,et al.  Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. , 2004, Molecular biology of the cell.

[52]  K. Matsuno,et al.  Drosophila Nedd4 Regulates Endocytosis of Notch and Suppresses Its Ligand-Independent Activation , 2004, Current Biology.

[53]  M. Cornell,et al.  Regulation of Notch Endosomal Sorting and Signaling by Drosophila Nedd4 Family Proteins , 2004, Current Biology.

[54]  T. Schedl,et al.  Epsin potentiates Notch pathway activity in Drosophila and C. elegans , 2004, Development.

[55]  K. Jones,et al.  Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. , 2004, Molecular cell.

[56]  Julian Lewis,et al.  Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development , 2004, Development.

[57]  H. Okano,et al.  Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling , 2004, Development.

[58]  G. Struhl,et al.  Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch , 2004, Development.

[59]  Erin Fitch,et al.  Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells , 2004, Development.

[60]  Andrew P. Weng,et al.  Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.

[61]  W. Hendrickson,et al.  Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA , 2004, The EMBO journal.

[62]  Julian Lewis,et al.  The vertebrate segmentation clock. , 2004, Current opinion in genetics & development.

[63]  A. Israël,et al.  Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor , 2004, The Journal of cell biology.

[64]  Ryoichiro Kageyama,et al.  Instability of Hes7 protein is crucial for the somite segmentation clock , 2004, Nature Genetics.

[65]  D. Wilkinson,et al.  Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. , 2004, Developmental cell.

[66]  F. Schweisguth,et al.  Regulation of Notch Signaling Activity , 2004, Current Biology.

[67]  Ning Chen,et al.  The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. , 2004, Developmental cell.

[68]  A. Xu,et al.  An O-fucose site in the ligand binding domain inhibits Notch activation , 2003, Development.

[69]  Luis M. Escudero,et al.  Echinoid synergizes with the Notch signaling pathway in Drosophila mesothorax bristle patterning , 2003, Development.

[70]  Philippe Montcourrier,et al.  Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila , 2003, Nature.

[71]  P. Rørth,et al.  Hrs mediates downregulation of multiple signalling receptors in Drosophila , 2003, EMBO reports.

[72]  D. Selkoe,et al.  Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. , 2003, Annual review of neuroscience.

[73]  A. Xu,et al.  Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe* , 2003, Journal of Biological Chemistry.

[74]  Gerhard K. H. Przemeck,et al.  Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1. , 2003, Journal of molecular biology.

[75]  N. Perrimon,et al.  neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions , 2003, Development.

[76]  Julius Brennecke,et al.  Identification of Drosophila MicroRNA Targets , 2003, PLoS biology.

[77]  K. Raj,et al.  The role of Notch in tumorigenesis: oncogene or tumour suppressor? , 2003, Nature Reviews Cancer.

[78]  K. Irvine,et al.  Glycosylation regulates Notch signalling , 2003, Nature Reviews Molecular Cell Biology.

[79]  J. Skeath,et al.  Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. , 2003, Developmental cell.

[80]  O. Pourquié.  The Segmentation Clock: Converting Embryonic Time into Spatial Pattern , 2003, Science.

[81]  F. Schweisguth,et al.  Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. , 2003, Developmental cell.

[82]  K. Irvine,et al.  Notch activity in neural cells triggered by a mutant allele with altered glycosylation , 2003, Development.

[83]  C. McGlade,et al.  Mammalian Numb Proteins Promote Notch1 Receptor Ubiquitination and Degradation of the Notch1 Intracellular Domain* , 2003, Journal of Biological Chemistry.

[84]  T. Klein,et al.  A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila , 2003, Development.

[85]  P. Stanley,et al.  Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[86]  A. Capobianco,et al.  The C-terminal PDZ-Ligand of JAGGED1 Is Essential for Cellular Transformation* 210 , 2003, The Journal of Biological Chemistry.

[87]  B. Emerson,et al.  Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. , 2003, Molecular cell.

[88]  Cheol‐Hee Kim,et al.  Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. , 2003, Developmental cell.

[89]  K. Irvine,et al.  Regulation of Notch Signaling by O-Linked Fucose , 2002, Cell.

[90]  Iva Greenwald,et al.  Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans , 2002, Nature.

[91]  U. Lendahl,et al.  p300 and PCAF Act Cooperatively To Mediate Transcriptional Activation from Chromatin Templates by Notch Intracellular Domains In Vitro , 2002, Molecular and Cellular Biology.

[92]  S. Artavanis-Tsakonas,et al.  Down-regulation of Delta by proteolytic processing , 2002, The Journal of cell biology.

[93]  Utpal Banerjee,et al.  An EGFR/Ebi/Sno Pathway Promotes Delta Expression by Inactivating Su(H)/SMRTER Repression during Inductive Notch Signaling , 2002, Cell.

[94]  M. Fortini,et al.  Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling , 2002, Nature Reviews Molecular Cell Biology.

[95]  M. Gonzalez-Gaitan,et al.  The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. , 2002, Developmental cell.

[96]  S. Barolo,et al.  Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. , 2002, Genes & development.

[97]  Yoshiko Takahashi,et al.  Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation. , 2002, Development.

[98]  J. Hsieh,et al.  A secreted Delta1‐Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling , 2002, Journal of neuroscience research.

[99]  K. Jones,et al.  Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. , 2002, Genes & development.

[100]  E. Lai.  Protein Degradation: Four E3s For The Notch Pathway , 2002, Current Biology.

[101]  E. Lai,et al.  Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. , 2001, Developmental cell.

[102]  G M Rubin,et al.  Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. , 2001, Developmental cell.

[103]  N. Moschonas,et al.  neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. , 2001, Developmental cell.

[104]  M. Gurney,et al.  SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation , 2001, Molecular and Cellular Biology.

[105]  M. Fortini.  Notch and presenilin: a proteolytic mechanism emerges. , 2001, Current opinion in cell biology.

[106]  M. Gurney,et al.  The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog* , 2001, The Journal of Biological Chemistry.

[107]  A. Ciechanover,et al.  Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor* , 2001, The Journal of Biological Chemistry.

[108]  D. Maier,et al.  Transcriptional repression by Suppressor of Hairless involves the binding of a Hairless-dCtBP complex in Drosophila , 2001, Current Biology.

[109]  S. Bray,et al.  Notch pathway: Making sense of Suppressor of Hairless , 2001, Current Biology.

[110]  S. Bray,et al.  A model Notch response element detects Suppressor of Hairless–dependent molecular switch , 2001, Current Biology.

[111]  A. Ciechanover,et al.  Functional Interaction between SEL-10 , an F-box Protein , and the Nuclear Form of Activated Notch 1 Receptor * , 2001 .

[112]  Raphael Kopan,et al.  Notch signaling: from the outside in. , 2000, Developmental biology.

[113]  S. Barolo,et al.  A Notch-Independent Activity of Suppressor of Hairless Is Required for Normal Mechanoreceptor Physiology , 2000, Cell.

[114]  I. Bernstein,et al.  Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. , 2000, Journal of cell science.

[115]  James D. Griffin,et al.  MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors , 2000, Nature Genetics.

[116]  T. Hunter,et al.  Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase* , 2000, The Journal of Biological Chemistry.

[117]  G. Struhl,et al.  Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. , 2000, Molecular cell.

[118]  Yang Wang,et al.  Fringe is a glycosyltransferase that modifies Notch , 2000, Nature.

[119]  S. Cohen,et al.  Glycosyltransferase activity of Fringe modulates Notch–Delta interactions , 2000, Nature.

[120]  T. Honjo,et al.  Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5* , 2000, The Journal of Biological Chemistry.

[121]  J. Kimble,et al.  Mastermind is a putative activator for Notch , 2000, Current Biology.

[122]  S. Bray,et al.  Spatially restricted factors cooperate with notch in the regulation of Enhancer of split genes. , 2000, Developmental biology.

[123]  J. Hsieh,et al.  SKIP, a CBF1-Associated Protein, Interacts with the Ankyrin Repeat Domain of NotchIC To Facilitate NotchIC Function , 2000, Molecular and Cellular Biology.

[124]  A. Parks,et al.  Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. , 2000, Development.

[125]  L. Luo,et al.  split ends encodes large nuclear proteins that regulate neuronal cell fate and axon extension in the Drosophila embryo. , 2000, Development.

[126]  F. Schweisguth,et al.  Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. , 2000, Genes & development.

[127]  A Cumano,et al.  A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. , 2000, Molecular cell.

[128]  Raphael Kopan,et al.  A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. , 2000, Molecular cell.

[129]  J. Aster,et al.  MAML 1 , a human homologue of Drosophila Mastermind , is a transcriptional coactivator for NOTCH receptors , 2000 .

[130]  I. Greenwald,et al.  SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans. , 1999, Genetics.

[131]  P. Rakic,et al.  Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. , 1999, Science.

[132]  K D Irvine,et al.  Fringe, Notch, and making developmental boundaries. , 1999, Current opinion in genetics & development.

[133]  S. Artavanis-Tsakonas,et al.  Notch signaling: cell fate control and signal integration in development. , 1999, Science.

[134]  J. Hsieh,et al.  CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[135]  P. Rakic,et al.  Processing of the notch ligand delta by the metalloprotease Kuzbanian. , 1999, Science.

[136]  R. Evans,et al.  A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. , 1998, Genes & development.

[137]  M. Muskavitch,et al.  Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. , 1998, Molecular biology of the cell.

[138]  Y. Jan,et al.  Numb-Associated Kinase Interacts with the Phosphotyrosine Binding Domain of Numb and Antagonizes the Function of Numb In Vivo , 1998, Molecular and Cellular Biology.

[139]  S. Artavanis-Tsakonas,et al.  Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. , 1997, Development.

[140]  S. Artavanis-Tsakonas,et al.  Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. , 1995, Development.