Upregulation of striatal adenosine A2A receptor mRNA in 6‐hydroxydopamine‐lesioned rats intermittently treated with L‐DOPA

To determine whether the adenosine A2A receptor might play a role in L‐DOPA‐induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A2A receptor mRNA in response to intermittent treatment with L‐DOPA in rats with dopaminergic denervation by 6‐hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L‐DOPA increased A2A receptor mRNA levels in the dopamine‐depleted striatum of 6‐OHDA‐lesioned rats exhibiting behavioral sensitization to L‐DOPA. These results suggest that A2A receptor activation is associated with the development of motor complications induced by L‐DOPA treatment. Synapse 52:218–222, 2004. © 2004 Wiley‐Liss, Inc.

[1]  Tzvetelina Dimitrova,et al.  Adenosine A2A receptor antagonist treatment of Parkinson’s disease , 2003, Neurology.

[2]  T. Suda,et al.  Rapid induction of serotonergic hyperinnervation in the adult rat striatum with extensive dopaminergic denervation , 2003, Neuroscience Letters.

[3]  M. Cenci,et al.  Cellular and behavioural effects of the adenosine A2a receptor antagonist KW‐6002 in a rat model of l‐DOPA‐induced dyskinesia , 2003, Journal of neurochemistry.

[4]  E. Hirsch,et al.  AMPA receptor antagonist LY293558 reverses preproenkephalin mRNA overexpression in the striatum of 6‐OHDA‐lesioned‐rats treated with l‐dopa , 2002, The European journal of neuroscience.

[5]  F. Pedata,et al.  Modification of adenosine extracellular levels and adenosine A(2A) receptor mRNA by dopamine denervation. , 2002, European journal of pharmacology.

[6]  M. Morelli,et al.  Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic‐intermittent L‐dopa and A2A receptor blockade plus L‐Dopa in dopamine‐denervated rats , 2002, Synapse.

[7]  E. Ongini,et al.  Persistent Behavioral Sensitization to Chronic l-DOPA Requires A2A Adenosine Receptors , 2002, The Journal of Neuroscience.

[8]  B. Fredholm,et al.  International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. , 2001, Pharmacological reviews.

[9]  M. Andersson,et al.  Persistent changes in striatal gene expression induced by long‐term l‐DOPA treatment in a rat model of Parkinson's disease , 2001, The European journal of neuroscience.

[10]  M. Morelli,et al.  Motor stimulant effects of the adenosine A2A receptor antagonist SCH 58261 do not develop tolerance after repeated treatments in 6‐hydroxydopamine‐lesioned rats , 2001, Synapse.

[11]  M. Ochi,et al.  Adenosine A(2A) receptor antagonists KF17837 and KW-6002 potentiate rotation induced by dopaminergic drugs in hemi-Parkinsonian rats. , 2000, European journal of pharmacology.

[12]  K. Fuxe,et al.  Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2A receptors in dopamine D2 receptor regulation in the rat dopamine‐denervated striatum , 2000, The European journal of neuroscience.

[13]  M. Ochi,et al.  Systemic administration of adenosine A2A receptor antagonist reverses increased GABA release in the globus pallidus of unilateral 6-hydroxydopamine-lesioned rats: a microdialysis study , 2000, Neuroscience.

[14]  P. Jenner,et al.  Combined Use of the Adenosine A2A Antagonist KW-6002 with l -DOPA or with Selective D1 or D2 Dopamine Agonists Increases Antiparkinsonian Activity but Not Dyskinesia in MPTP-Treated Monkeys , 2000, Experimental Neurology.

[15]  P. Jenner,et al.  Alterations in preproenkephalin and adenosine‐2a receptor mRNA, but not preprotachykinin mRNA correlate with occurrence of dyskinesia in normal monkeys chronically treated with l‐DOPA , 2000, The European journal of neuroscience.

[16]  L. Grégoire,et al.  Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys , 1999, Neurology.

[17]  T. Suda,et al.  Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats. , 1999, Neuroreport.

[18]  T. Suda,et al.  Loss of regulation by presynaptic dopamine D2 receptors of exogenous l-DOPA-derived dopamine release in the dopaminergic denervated striatum , 1999, Brain Research.

[19]  J. Brotchie,et al.  Characterization of Enhanced Behavioral Responses tol-DOPA Following Repeated Administration in the 6-Hydroxydopamine-Lesioned Rat Model of Parkinson's Disease , 1998, Experimental Neurology.

[20]  P. Jenner,et al.  Adenosine A2A Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeys , 1998, Annals of neurology.

[21]  P. Svenningsson,et al.  Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas , 1997, Neuroscience.

[22]  E. Ongini,et al.  Adenosine A2A receptor antagonism potentiates L-DOPA-induced turning behaviour and c-fos expression in 6-hydroxydopamine-lesioned rats. , 1997, European journal of pharmacology.

[23]  J. Palacios,et al.  Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization , 1996, Neuroscience.

[24]  J. Brotchie,et al.  Potential of Opioid Antagonists in the Treatment of Levodopa-Induced Dyskinesias in Parkinson’s Disease , 1996, Drugs & aging.

[25]  G. Di Chiara,et al.  Adenosine A2 receptors interact negatively with dopamine D1 and D2 receptors in unilaterally 6-hydroxydopamine-lesioned rats. , 1994, European journal of pharmacology.

[26]  J. Vanderhaeghen,et al.  Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[27]  H. Bergman,et al.  Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. , 1990, Science.

[28]  Y. Agid,et al.  Continuous and intermittent levodopa differentially affect basal ganglia function , 1989, Annals of neurology.

[29]  J. Burgunder,et al.  Adenosine A2A receptor gene expression in the normal striatum and after 6-OH-dopamine lesion , 2000, Journal of Neural Transmission.

[30]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .