Design, Formulation, and Evaluation of Piroxicam Niosomal Gel

Objective: The objective of the present study was incorporati n PIR niosomes in different gel bases to develop (PIR) gel for tansdermal delivery. Method: PIR niosomes were prepared by lipid evaporation me thod and all vesicles were evaluated for their entrapment effici n y (EE%), and in-vitro drug release. PIR gels wer e prepared using sodium alginate, methyl cellulose (M C), hydroxyl propyl methyl cellulose (HPMC), carbox y methyl cellulose (CMC), and xanthan gum. The effect of type and concentration of the employed gel base s on the permeation was tested. The viscosity of gel fo rmulae and also the shelf life were evaluated. Results: The results showed that polymers type affect the drug p ermeation and rheological properties of PIR niosoma l gel. F3 containing 4% MC showed the best permeation thro ugh rat skin (87.73 + 2.06) and the lowest viscosity. Conclusion: All the studied gels are of acceptable physical pr ope ties and drug content. They exhibited pseudoplastic flow with thixotropic behavior. Consi dering in-vitro permeation, rheological properties, and shelf life, F3 (4% MC) formula was the best.