Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression
暂无分享,去创建一个
Andrea Califano | William Shin | John F. Crary | A. Califano | C. Lefebvre | J. Crary | M. Shelanski | Yasir H. Qureshi | Celine Lefebvre | Soline Aubry | Soline Aubry | Roger Lefort | Michael L. Shelanski | R. Lefort | William Shin
[1] Andrea Califano,et al. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. , 2013, Cancer cell.
[2] J. Pozueta,et al. Synaptic changes in Alzheimer’s disease and its models , 2013, Neuroscience.
[3] L. Tran,et al. Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.
[4] J. Pozueta,et al. Cross-Linking of Cell Surface Amyloid Precursor Protein Leads to Increased β-Amyloid Peptide Production in Hippocampal Neurons: Implications for Alzheimer's Disease , 2012, The Journal of Neuroscience.
[5] A. Butte,et al. Leveraging models of cell regulation and GWAS data in integrative network-based association studies , 2012, Nature Genetics.
[6] Andrea Califano,et al. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL , 2011, Nature Medicine.
[7] Dong-Sun Han,et al. Acetylation of the Pro-Apoptotic Factor, p53 in the Hippocampus following Cerebral Ischemia and Modulation by Estrogen , 2011, PloS one.
[8] Menno P. Witter,et al. A pathophysiological framework of hippocampal dysfunction in ageing and disease , 2011, Nature Reviews Neuroscience.
[9] W. Gu,et al. The impact of acetylation and deacetylation on the p53 pathway , 2011, Protein & Cell.
[10] S. Feinstein,et al. Amyloid β-Mediated Cell Death of Cultured Hippocampal Neurons Reveals Extensive Tau Fragmentation without Increased Full-length Tau Phosphorylation* , 2011, The Journal of Biological Chemistry.
[11] J. Trojanowski,et al. The acetylation of tau inhibits its function and promotes pathological tau aggregation. , 2011, Nature communications.
[12] N. Sharma,et al. Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14 , 2010, Proceedings of the National Academy of Sciences.
[13] T. Kundu,et al. Tuning acetylation levels with HAT activators: therapeutic strategy in neurodegenerative diseases. , 2010, Biochimica et biophysica acta.
[14] Mariano J. Alvarez,et al. A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers , 2010, Molecular systems biology.
[15] Winnie S. Liang,et al. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology , 2010, Neurobiology of Aging.
[16] J. Uhm,et al. The transcriptional network for mesenchymal transformation of brain tumours , 2010 .
[17] E. Yaksi,et al. Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy , 2010, Neuron.
[18] Christopher M. Overall,et al. Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology , 2009, Trends in Neurosciences.
[19] E. Koo,et al. Amyloid Precursor Protein Trafficking, Processing, and Function* , 2008, Journal of Biological Chemistry.
[20] S. Weitzman,et al. p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc , 2008, Oncogene.
[21] P. Casaccia‐Bonnefil,et al. The Yin and Yang of YY1 in the nervous system , 2008, Journal of neurochemistry.
[22] Eric M Reiman,et al. Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. , 2008, Physiological genomics.
[23] Winnie S. Liang,et al. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons , 2008, Proceedings of the National Academy of Sciences.
[24] D. Geschwind,et al. A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging , 2008, The Journal of Neuroscience.
[25] Geoffrey E. Hinton,et al. Visualizing Data using t-SNE , 2008 .
[26] J. Vonsattel,et al. Twenty-first century brain banking. Processing brains for research: the Columbia University methods , 2007, Acta Neuropathologica.
[27] Nathaniel D. Heintzman,et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome , 2007, Nature Genetics.
[28] Tony Wyss-Coray,et al. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? , 2006, Nature Medicine.
[29] K. Nowak,et al. The transcription factor Yin Yang 1 is an activator of BACE1 expression , 2006, Journal of neurochemistry.
[30] B. Bonavida,et al. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology , 2006, Oncogene.
[31] P. Keller,et al. Globular amyloid β‐peptide1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease , 2005 .
[32] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[33] Ching-Chow Chen,et al. Akt Phosphorylation of p300 at Ser-1834 Is Essential for Its Histone Acetyltransferase and Transcriptional Activity , 2005, Molecular and Cellular Biology.
[34] R. Kraft,et al. Caspase-Dependent Regulation and Subcellular Redistribution of the Transcriptional Modulator YY1 during Apoptosis , 2005, Molecular and Cellular Biology.
[35] Adam A. Margolin,et al. Reverse engineering of regulatory networks in human B cells , 2005, Nature Genetics.
[36] S. Kyrylenko,et al. Changes in DNA binding pattern of transcription factor YY1 in neuronal degeneration , 2005, Neuroscience Letters.
[37] P. Keller,et al. Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. , 2005, Journal of neurochemistry.
[38] J. Ericsson,et al. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[39] Rafael A. Irizarry,et al. A Model-Based Background Adjustment for Oligonucleotide Expression Arrays , 2004 .
[40] S. Grossman,et al. Yin Yang 1 Is a Negative Regulator of p53 , 2004, Cell.
[41] O. Vitolo,et al. Dendrite and dendritic spine alterations in alzheimer models , 2004, Journal of neurocytology.
[42] M. Ball,et al. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia , 1977, Acta Neuropathologica.
[43] Wei Gu,et al. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. , 2003, Current opinion in cell biology.
[44] Richard Mohs,et al. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. , 2003, Archives of neurology.
[45] R. Shiekhattar,et al. A Candidate X-linked Mental Retardation Gene Is a Component of a New Family of Histone Deacetylase-containing Complexes* , 2003, The Journal of Biological Chemistry.
[46] M. Ball,et al. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signaling , 2002, Journal of neuroscience research.
[47] F. Speleman,et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes , 2002, Genome Biology.
[48] J M Lee,et al. A gene expression profile of Alzheimer's disease. , 2001, DNA and cell biology.
[49] Ya-Li Yao,et al. Regulation of Transcription Factor YY1 by Acetylation and Deacetylation , 2001, Molecular and Cellular Biology.
[50] N. L. La Thangue,et al. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. , 2001, Journal of cell science.
[51] R. Goodman,et al. CREB-binding Protein and p300 in Transcriptional Regulation* , 2001, The Journal of Biological Chemistry.
[52] Ettore Appella,et al. p300/CBP‐mediated p53 acetylation is commonly induced by p53‐activating agents and inhibited by MDM2 , 2001, The EMBO journal.
[53] R. Hay,et al. Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation , 2000, Molecular and Cellular Biology.
[54] H. Ropers,et al. DXS6673E encodes a predominantly nuclear protein, and its mouse ortholog DXHXS6673E is alternatively spliced in a developmental- and tissue-specific manner. , 2000, Genomics.
[55] D. Holtzman,et al. In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease. , 1999, Journal of neuropathology and experimental neurology.
[56] E. Seto,et al. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? , 1999, Gene.
[57] Christina A. Wilson,et al. Intracellular APP Processing and Aβ Production in Alzheimer Disease , 1999 .
[58] S. Shimohama,et al. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. , 1999, Biochemical and biophysical research communications.
[59] R. Doms,et al. Intracellular APP processing and A beta production in Alzheimer disease. , 1999, Journal of neuropathology and experimental neurology.
[60] K. Sakaguchi,et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. , 1998, Genes & development.
[61] J. Wands,et al. Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease , 1997, Journal of the Neurological Sciences.
[62] J. Kere,et al. Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1. , 1996, Human molecular genetics.
[63] K. Becker,et al. Characterization of hUCRBP (YY1, NF-E1, delta): a transcription factor that binds the regulatory regions of many viral and cellular genes. , 1994, Gene.
[64] D. Selkoe. The molecular pathology of Alzheimer's disease , 1991, Neuron.
[65] A. Nappi,et al. Alzheimer ' s Disease : Cell-Specific Pathology Isolates the Hippocampal Formation , 2022 .