Treating delayed perforation after esophageal endoscopic submucosal dissection using polyglycolic acid sheets and fibrin glue

Delayed perforation after esophageal endoscopic submucosal dissection (ESD) is rare but can be a serious complication and may require surgical treatment [1]. Recently, polyglycolic acid (PGA) sheets have been used as conservative treatment for delayed perforation after ESD in the stomach [2, 3] and colon [4]. A 78-year-old man underwent ESD for a superficial esophageal cancer located on a previous ESD scar. The tumor was resected without any adverse events (▶Fig. 1 a) and steroid was injected into the submucosal layer around themucosal defect to prevent stenosis after ESD. On postoperative day 21, the patient was brought into the emergency department with impaired consciousness. Computed tomography showed mediastinal emphysema and the patient was diagnosed with delayed perforation after the esophageal ESD. Endoscopy revealed a large perforation on the esophageal ESD-induced mucosal defect (▶Fig. 1b). Endoscopic closure using endoclips was deemed too difficult because of the large size of the perforation and the fragility of the surrounding tissue. The patient’s vital signs were stable, so we attempted to use PGA sheets (Neoveil; Gunze, Kyoto, Japan) to repair the defect (▶Video 1). After the perforation had been cleaned with saline solution, PGA sheets cut into 20×10-mm strips were inserted into the perforation via the endoscope channel using a grasping forceps. After the perforation had been filled with enough PGA sheets (▶Fig. 1 c), we fixed them using fibrin glue (Beriplast P Combi-Set; CSL Behring Pharma, Tokyo, Japan). After the procedure, the patient was managed conservatively with antibiotics and his general condition improved. Repeat endoscopy on day 17 following the Video 1 A delayed perforation in the mucosal defect after esophageal endoscopic submucosal dissection is treated using polyglycolic acid sheets and fibrin glue, leading to complete closure of the defect by day 40. ▶ Fig. 1 Endoscopic images showing: a the mucosal defect immediately after endoscopic submucosal dissection, with no evidence of perforation seen; b the delayed perforation visible on an endoscopy performed on day 21; c the perforation after it had been filled with polyglycolic acid sheets; d the site of the perforation 17 days later, with the polyglycolic acid sheets in place and the perforation having decreased in size; e the site of the delayed perforation 40 days later, with complete closure being confirmed. E-Videos