Networks are working at their apical efficiency and are increasing in size by every second; emergence of various threats becomes hindrance in the growth and privacy of the users. The network is vulnerable to security breaches, due to malicious nodes. Intrusion detection systems aim at removing this vulnerability. In this paper, intrusion detection mechanisms for large-scale dynamic networks are investigated. Artificial immune system is a concept that works to protect a network the way immune systems of vertebrates work in nature. This paper also illustrates this artificial immune system, the integration of bio-inspired algorithms, and its functionality with the computer networks.