Genomics: Beyond the book of life

It was the year of genomes. Every week seemed to bring another landmark — be it human, animal, plant or pathogen. But there was more to 2000 than strings of 'A's, 'C's, 'G's and 'T's. Nature explores some of the highs, lows and emerging trends behind the year's scientific headlines.

[1]  A new era , 2000, Nature Structural Biology.

[2]  Sebastian A. Leidel,et al.  Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III , 2000, Nature.

[3]  Melanie E. Goward,et al.  The DNA sequence of human chromosome 22 , 1999, Nature.

[4]  Yudong D. He,et al.  Functional Discovery via a Compendium of Expression Profiles , 2000, Cell.

[5]  James R. Knight,et al.  A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae , 2000, Nature.

[6]  Stephen M. Mount,et al.  The genome sequence of Drosophila melanogaster. , 2000, Science.

[7]  Peter G. Schultz,et al.  A chemical switch for inhibitor-sensitive alleles of any protein kinase , 2000, Nature.

[8]  Ash A. Alizadeh,et al.  Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling , 2000, Nature.

[9]  P. Zipperlen,et al.  Functional genomic analysis of C. elegans chromosome I by systematic RNA interference , 2000, Nature.

[10]  Steve D. M. Brown,et al.  A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse , 2000, Nature Genetics.

[11]  Christian A. Rees,et al.  Molecular portraits of human breast tumours , 2000, Nature.

[12]  S. Schreiber,et al.  Printing proteins as microarrays for high-throughput function determination. , 2000, Science.

[13]  Klaus Schughart,et al.  Genome-wide, large-scale production of mutant mice by ENU mutagenesis , 2000, Nature Genetics.

[14]  D. A. Palmieri,et al.  The genome sequence of the plant pathogen Xylella fastidiosa , 2000, Nature.

[15]  T. Hughes,et al.  Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. , 2000, Science.

[16]  S. Salzberg,et al.  DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae , 2000, Nature.

[17]  S. Haggarty,et al.  Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. , 1999, Science.

[18]  The Arabidopsis Genome Initiative.  Analysis of the genome sequence of the flowering plant Arabidopsis thaliana , 2000, Nature.

[19]  S. Lory,et al.  Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen , 2000, Nature.