John Martin Wood (1938-2008)--pioneering biochemist, educator and communicator.

John Martin Wood, Emeritus Professor of Medical Biochemistry at the University of Bradford died in Wieck by Greifswald, Germany after a short illness on February 5, 2008 - just short of his 70(th) year. John worked as a pioneering biochemist and educator in the US and in Britain across two research careers. He devoted the first twenty-five years to the role of transition metals in biology, and his last twenty-years to cutaneous enzymology and melanogenesis. Working together with his wife Professor Karin U. Schallreuter, his research on oxidative stress handling in skin and on the expression of a cutaneous catecholaminergic system will help direct research in these fields for many years to come. John impressed on his fellow cutaneous researchers and students the critical importance of appreciating the true role of enzymes in skin health and disease. This obituary aims to contextualize the significant contributions made by this remarkable man to experimental dermatology.

[1]  J. Wood,et al.  Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH‐binding and tetramerization domains: a genetic predisposition for an altered catalase in patients with vitiligo? , 2008, Experimental dermatology.

[2]  N. J. Gibbons,et al.  Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo. , 2008, The Journal of investigative dermatology.

[3]  M. Pittelkow,et al.  Structural and functional alterations in the β2‐adrenoceptor are caused by a point mutation in patients with atopic eczema , 2007 .

[4]  J. Wood,et al.  Regulation of tyrosinase by tetrahydropteridines and H2O2. , 2004, Biochemical and biophysical research communications.

[5]  R. Dummer,et al.  Epidermal H(2)O(2) accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent processes? , 2001, The Journal of investigative dermatology.

[6]  J. Wood,et al.  Evidence for specific complex formation between alpha-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infrared Fourier transform Raman spectroscopy. , 1999, Biochemistry.

[7]  J. Wood,et al.  The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes. , 1999, Biochemical and biophysical research communications.

[8]  R. Boissy,et al.  What's the use of generating melanin? , 1999, Experimental dermatology.

[9]  D. Tobin,et al.  Pterins in human hair follicle cells and in the synchronized murine hair cycle. , 1998, The Journal of investigative dermatology.

[10]  M. Pittelkow,et al.  Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. , 1994, Science.

[11]  J. Wood,et al.  The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase. , 1990, Biochimica et biophysica acta.

[12]  M. Pittelkow,et al.  Free radical reduction by thioredoxin reductase at the surface of normal and vitiliginous human keratinocytes. , 1986, The Journal of investigative dermatology.