Does EEG Montage Influence Alzheimer's Disease Electroclinic Diagnosis?

There is not a specific Alzheimer's disease (AD) diagnostic test. AD diagnosis relies on clinical history, neuropsychological, and laboratory tests, neuroimaging and electroencephalography. Therefore, new approaches are necessary to enable earlier and more accurate diagnosis and to measure treatment results. Quantitative EEG (qEEG) can be used as a diagnostic tool in selected cases. The aim of this study was to answer if distinct electrode montages have different sensitivity when differentiating controls from AD patients. We analyzed EEG spectral peaks (delta, theta, alpha, beta, and gamma bands), and we compared references (Biauricular, Longitudinal bipolar, Crossed bipolar, Counterpart bipolar, and Cz reference). Support Vector Machines and Logistic Regression classifiers showed Counterpart bipolar montage as the most sensitive electrode combination. Our results suggest that Counterpart bipolar montage is the best choice to study EEG spectral peaks of controls versus AD.

[1]  M. Storandt,et al.  A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years. , 1985, Electroencephalography and clinical neurophysiology.

[2]  B Stigsby,et al.  Regional EEG analysis and regional cerebral blood flow in Alzheimer's and Pick's diseases. , 1981, Electroencephalography and clinical neurophysiology.

[3]  Li Wang,et al.  The effect of reference choices on the spatio-temporal analysis of brain evoked potentials: The use of infinite reference , 2007, Comput. Biol. Medicine.

[4]  Hojjat Adeli,et al.  Alzheimer's Disease: Models of Computation and Analysis of EEGs , 2005, Clinical EEG and neuroscience.

[5]  P. R. D. de Bittencourt,et al.  [Digital EEG with brain mapping in Alzheimer's dementia and Parkinson's disease. A prospective controlled study]. , 1996, Arquivos de neuro-psiquiatria.

[6]  H. Semlitsch,et al.  Relations between symptomatology and brain function in dementias: double-blind, placebo-controlled, clinical and EEG/ERP mapping studies with nicergoline. , 1997, Dementia and geriatric cognitive disorders.

[7]  D B Hier,et al.  Quantitative Measurement of Delta Activity in Alzheimer's Disease , 1991, Clinical EEG.

[8]  H. Jasper,et al.  The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[9]  D O Walter,et al.  Regional differences in brain electrical activity in dementia: use of spectral power and spectral ratio measures. , 1993, Electroencephalography and clinical neurophysiology.

[10]  H. Vankova.  Mini Mental State , 2010 .

[11]  M. C. Sandmann,et al.  Eletrencefalograma digital com mapeamento em demência de Alzheimer e doença de Parkinson: estudo prospectivo controlado , 1996 .

[12]  David W. Hosmer,et al.  Applied Logistic Regression , 1991 .

[13]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[14]  G. Comi,et al.  IFCN standards for digital recording of clinical EEG. The International Federation of Clinical Neurophysiology. , 1998, Electroencephalography and clinical neurophysiology. Supplement.

[15]  D. Lehmann.  Multichannel topography of human alpha EEG fields. , 1971, Electroencephalography and clinical neurophysiology.

[16]  Ian Witten,et al.  Data Mining , 2000 .

[17]  Petra N. Davidson,et al.  Electroencephalography in the Elderly , 2012, The Neurodiagnostic journal.

[18]  F. Angeleri,et al.  EEG power spectrum differences in early and late onset forms of Alzheimer's disease , 1999, Clinical Neurophysiology.

[19]  R. Nitrini,et al.  qEEG spectral peak in Alzheimer’s disease: A possible tool for treatment follow-up , 2008, Dementia & neuropsychologia.

[20]  Paulo Caramelli,et al.  Sugestões para o uso do mini-exame do estado mental no Brasil , 2003 .

[21]  W. Shankle,et al.  qEEG Monitoring of Alzheimer's Disease Treatment: A Preliminary Report of Three Case Studies , 2006, Clinical EEG and neuroscience.

[22]  R. Nitrini,et al.  qEEG spectral peak in Alzheimer's disease , 2008 .

[23]  Renato Anghinah,et al.  Estudo da densidade espectral e da coerência do eletroencefalograma em indivíduos adultos normais e com doença de Alzheimer provável , 2003 .

[24]  Vladimir N. Vapnik,et al.  The Nature of Statistical Learning Theory , 2000, Statistics for Engineering and Information Science.

[25]  Peter Rappelsberger,et al.  The reference problem and mapping of coherence: A simulation study , 2005, Brain Topography.

[26]  D. Pregibon.  Logistic Regression Diagnostics , 1981 .

[27]  H. Soininen,et al.  Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. , 1985, Electroencephalography and clinical neurophysiology.

[28]  Nello Cristianini,et al.  An Introduction to Support Vector Machines and Other Kernel-based Learning Methods , 2000 .

[29]  F. Rubia,et al.  Topographic maps of brain electrical activity in primary degenerative dementia of the Alzheimer type and multiinfarct dementia , 1991, Biological Psychiatry.

[30]  N. Greig,et al.  Advances in Alzheimer therapy: understanding pharmacological approaches to the disease. , 2009, Current Alzheimer research.

[31]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[32]  L. Berg,et al.  Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type. , 1983, Electroencephalography and clinical neurophysiology.

[33]  Renato Anghinah,et al.  Recomendaçöes para o registro/interpretaçäo do mapeamento topográfico do eletrencefalograma e potenciais evocados: parte II: correlaçöes clínicas , 1999 .

[34]  Y. Kwak,et al.  Quantitative EEG Findings in Different Stages of Alzheimer’s Disease , 2006, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[35]  Ricardo Nitrini,et al.  [Suggestions for utilization of the mini-mental state examination in Brazil]. , 2003, Arquivos de neuro-psiquiatria.

[36]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease , 2011, Neurology.

[37]  Thomas Dierks,et al.  Topography of the quantitative electroencephalogram in dementia of the alzheimer type: Relation to severity of dementia , 1991, Psychiatry Research: Neuroimaging.

[38]  Saeid Sanei,et al.  EEG signal processing , 2000, Clinical Neurophysiology.

[39]  F H Duffy,et al.  Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type , 1984, Annals of neurology.

[40]  F H Duffy,et al.  Brain electrical activity mapping (BEAM): A method for extending the clinical utility of EEG and evoked potential data , 1979, Annals of neurology.

[41]  G. Comi,et al.  IFCN standards for digital recording of clinical EEG. International Federation of Clinical Neurophysiology. , 1998, Electroencephalography and clinical neurophysiology.

[42]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[43]  D. O. Walter,et al.  Electroencephalographic spectra and coherence in the diagnosis of Alzheimer's-type and multi-infarct dementia. A pilot study. , 1987, Archives of general psychiatry.