The Circular Dichroism Spectrum and Structure of Unordered Polypeptides and Proteins

The evidence bearing on our revision of the early assignment of the circular dichroism spectrum of the maximally unordered polypeptide chain is reviewed. Our initial, as well as subsequent, studies are believed to support the proposed revision in assignment. This conclusion need not be modified in the light of recent work on water-soluble, non-ionizable polymers.

[1]  E. Blout,et al.  Synthesis and structural investigation of poly(L-alanyl-L-alanyl-glycine). , 1970, Journal of molecular biology.

[2]  D. Torchia,et al.  A Nuclear Magnetic Resonance Study of Poly(L-proline) in Aqueous and Aqueous Salt Solutions , 1971 .

[3]  E. Blout,et al.  Synthesis and structural studies of two collagen analogues: poly (L-prolyl-L-seryl-glycyl) and poly (L-prolyl-L-alanyl-glycyl). , 1972, Journal of molecular biology.

[4]  C. Venkatachalam,et al.  Free-energy calculations of the interactions of helical poly(L-proline) with water. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[5]  P. Doty,et al.  Polypeptides. VIII. Molecular configurations of poly‐L‐glutamic acid in water‐dioxane solution , 1957 .

[6]  S. Krimm,et al.  Effwct of temperature on the circular dichroism spectra of polypeptides in the extended state , 1972, Biopolymers.

[7]  G. Fasman,et al.  Circular dichroism of polypeptide and protein conformations. Film studies. , 1970, Biochemistry.

[8]  A. Hopfinger,et al.  Helix-coil controversy for polyamino acids. , 1972, Journal of the American Chemical Society.

[9]  H. D. Keith.  Supporting evidence for an extended helical conformation in Poly(L-glutamic acid) , 1971 .

[10]  W. G. Miller,et al.  Electrostatic interactions in polyglutamic acid , 1973, Biopolymers.

[11]  Y. Myer.  The pH-Induced Helix-Coil Transition of Poly-L-lysine and Poly-L-glutamic Acid and the 238-mμ Dichroic Band , 1969 .

[12]  Y H Chen,et al.  Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion. , 1972, Biochemistry.

[13]  Charles Tanford,et al.  Physical Chemistry of Macromolecules , 1961 .

[14]  Harold A. Scheraga,et al.  Conformational Analysis of Macromolecules. IV. Helical Structures of Poly‐L‐Alanine, Poly‐L‐Valine, Poly‐β‐Methyl‐L‐Aspartate, Poly‐γ‐Methyl‐L‐Glutamate, and Poly‐L‐Tyrosine , 1967 .

[15]  S. Krimm,et al.  Theoretical calculation of the circular dichroism of unordered polypeptide chains , 1972, Biopolymers.

[16]  J. E. Mark,et al.  Influence of counterions on the helical conformations of charged polypeptide chains , 1969 .

[17]  W. G. Miller,et al.  Effect of residual side chain blocking groups and side chain charge on polypeptide conformation in aqueous solution , 1973, Biopolymers.

[18]  E. S. Pysh.  Scalar spectral characteristics of one- dimensional solids , 1970 .

[19]  B. Lotz,et al.  Crystal structure of poly(L-Ala-Gly)II. A model for silk. I. , 1971, Journal of molecular biology.

[20]  G. N. Ramachandran,et al.  Stereochemical criteria for polypeptide and protein chain conformations. 3. Helical and hydrogen-bonded polypeptide chains. , 1966, Biophysical journal.

[21]  J. E. Mark,et al.  Conformations of polypeptides with ionized side chains of equal length. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[22]  W. Scholtan,et al.  Eine verbesserte Methode zur Konformationsbestimmung von helicalen Proteinen aus Messungen des Circulardichroismus , 1971 .

[23]  A. Berger,et al.  Conformation changes in the nonionizable water‐soluble synthetic polypeptide poly‐N5‐(3‐hydroxypropyl) ‐L‐glutamine , 1965 .

[24]  J. T. Yang,et al.  The viscosity of macromolecules in relation to molecular conformation. , 1961, Advances in protein chemistry.

[25]  S. Krimm,et al.  Circular dichroism of poly-L-proline in an unordered conformation. , 1968, Biopolymers.

[26]  D. Torchia,et al.  Carbon-13 and proton nuclear magnetic resonance observations of the conformation of poly(L-proline) in aqueous salt solutions. , 1973, Macromolecules.

[27]  E. Blout,et al.  Low temperature circular dichroism of poly (glycyl-L-prolyl-L-alanine). , 1969, Journal of molecular biology.

[28]  I. Tinoco,et al.  Optical Rotation of Oriented Helices. III. Calculation of the Rotatory Dispersion and Circular Dichroism of the Alpha‐ and 310‐Helix , 1967 .

[29]  E. S. Pysh.  The calculated ultraviolet optical properties of poly-L-proline I and II. , 1967, Journal of molecular biology.

[30]  H. Eisenberg,et al.  Studies on the viscosity of solutions of bovine liver glutamate dehydrogenase and on related hydrodynamic models; effect of toluene on enzyme association , 1970, Biopolymers.

[31]  K. Piez,et al.  Characterization of the product formed by renaturation of alpha 1-CB2, a small peptide from collagen. , 1970, Biochemistry.

[32]  J. Schellman,et al.  Optical activity of polypeptides and proteins , 1972, Biopolymers.

[33]  E. S. Pysh,et al.  Optical properties of amorphous polypeptides. I. One state solutions. , 1970, The Journal of chemical physics.

[34]  R. Hawkins,et al.  Some Macromolecular Properties of Poly(α-L-glutamic acid) Random Coils , 1972 .

[35]  D. Wetlaufer,et al.  Circular dichroism of putative unordered polypeptides and proteins. , 1970, Biochemical and biophysical research communications.

[36]  F. Naider,et al.  Conformation of cyclolinopeptide a observed by circular dichroism. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[37]  M. Volkenstein,et al.  Circular dichroism calculation for random‐coil polypeptide chains , 1971 .

[38]  R. Woody.  Improved calculation of the n-pi rotational strength in polypeptides. , 1968, The Journal of chemical physics.

[39]  D. Wetlaufer,et al.  A new basis for interpreting the circular dichroic spectra of proteins. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. Schimmel,et al.  Conformational energy and configurational statistics of poly-L-proline. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[41]  K. Rosenheck,et al.  Theory of the Far‐Ultraviolet Spectrum of Polypeptides in the β Conformation , 1967 .

[42]  S. Krimm,et al.  Circular dichroism of the “random” polypeptide chain , 1969 .

[43]  A. Walton,et al.  Optical properties of the polyglycine II helix , 1971, Biopolymers.

[44]  A. Walton,et al.  Spectroscopic characterization of poly(Glu-Ala). , 1973, Journal of molecular biology.

[45]  F. Loxsom,et al.  Theoretical optical properties of poly‐L‐proline , 1973 .

[46]  S. Krimm,et al.  New chain conformations of poly(glutamic acid) and polylysine. , 1968, Biopolymers.

[47]  P. Doty,et al.  THE ULTRAVIOLET CIRCULAR DICHROISM OF POLYPEPTIDES. , 1965, Journal of the American Chemical Society.

[48]  P. Flory,et al.  Conformational energy estimates for statistically coiling polypeptide chains , 1967 .

[49]  C. Toniolo,et al.  Conformational aspects of polypeptide structure. XXX. Rotatory properties of cyclic and bicyclic amides. Restricted and rigid model compounds for peptide chromophores. , 1969, Journal of the American Chemical Society.

[50]  Harold A. Scheraga,et al.  Conformational Analysis of Macromolecules. III. Helical Structures of Polyglycine and Poly‐L‐Alanine , 1966 .

[51]  W. Mattice,et al.  A Comparison of the Effects of Salt and Temperature on Charged and Uncharged Polypeptides in Water , 1972 .

[52]  S. Krimm,et al.  Extended conformations of polypeptides and proteins in urea and guanidine hydrochloride , 1973 .

[53]  G. Fasman,et al.  Circular dichroism of polypeptides. Poly(hydroxyethyl-L-glutamine) compared to poly(L-glutamic acid). , 1968, Journal of the American Chemical Society.

[54]  E. S. Pysh.  The calculated ultraviolet optical properties of polypeptide beta-configurations. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[55]  A. Walton,et al.  Morphological and structural studies of poly(gly‐gly‐ala) , 1971, Biopolymers.

[56]  R. Woody.  Optical properties of polypeptides in the β‐conformation , 1969 .