Intravenous tranexamic acid and intraoperative visualization during functional endoscopic sinus surgery: a double‐blind randomized controlled trial

Bleeding during endoscopic sinus surgery (ESS) can hinder surgical progress and may be associated with increased complications. Tranexamic acid is an antifibrinolytic that is known to reduce operative bleeding. The current study was designed to assess the effect of adjunctive intravenous tranexamic acid on intraoperative bleeding and the quality of the surgical field during ESS.

[1]  M. Mohseni,et al.  The effect of intravenous tranexamic acid on blood loss and surgical field quality during endoscopic sinus surgery: a placebo-controlled clinical trial. , 2011, Journal of clinical anesthesia.

[2]  K. Ker,et al.  Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. , 2011, The Cochrane database of systematic reviews.

[3]  Andrew Smith,et al.  Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: a systematic review and meta-analysis. , 2011, Journal of cardiothoracic and vascular anesthesia.

[4]  J. Eubanks Antifibrinolytics in Major Orthopaedic Surgery , 2010, The Journal of the American Academy of Orthopaedic Surgeons.

[5]  A. Beule,et al.  Standardized Video‐Endoscopy and Surgical Field Grading Scale for Endoscopic Sinus Surgery: A Multi‐Centre Study , 2008, The Laryngoscope.

[6]  S. Agrawal,et al.  Impact of Perioperative Systemic Steroids on Surgical Outcomes in Patients With Chronic Rhinosinusitis With Polyposis: Evaluation With the Novel Perioperative Sinus Endoscopy (POSE) Scoring System , 2007, The Laryngoscope.

[7]  A. Beule,et al.  Effects of Topical Antifibrinolytics in Endoscopic Sinus Surgery: A Pilot Randomized Controlled Trial , 2007, American journal of rhinology.

[8]  P. Wormald,et al.  The Effect of the Total Intravenous Anesthesia Compared with Inhalational Anesthesia on the Surgical Field during Endoscopic Sinus Surgery , 2005, American journal of rhinology.

[9]  C. Sabbà,et al.  Rendu-Osler-Weber disease: experience with 56 patients. , 2002, Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna.

[10]  A. Coetzee,et al.  Comparison of sodium nitroprusside- and esmolol-induced controlled hypotension for functional endoscopic sinus surgery , 1995, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[11]  K. Goa,et al.  Tranexamic acid: a review of its use in surgery and other indications. , 1999, Drugs.