Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes
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J. Mill | T. Raj | K. Lunnon | P. Heutink | P. Rizzu | J. Humphrey | T. Lashley | C. Bettencourt | Megha N. Murthy | MEGHA N. Murthy | Christina E. Toomey | Katherine Fodder | Rahat Hasan
[1] S. Fernández-Barrés,et al. A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation , 2023, Epigenetics.
[2] I. Fyfe. Surprise neurovascular dysfunction in frontotemporal dementia , 2022, Nature Reviews Neurology.
[3] J. V. van Swieten,et al. Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex , 2022, Nature Neuroscience.
[4] D. Biard,et al. HS3ST2 expression induces the cell autonomous aggregation of tau , 2022, Scientific Reports.
[5] K. Winklhofer,et al. The Role of Ubiquitin in Regulating Stress Granule Dynamics , 2022, Frontiers in Physiology.
[6] A. Buchberger,et al. Role of the Ubiquitin System in Stress Granule Metabolism , 2022, International journal of molecular sciences.
[7] J. Mill,et al. DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types , 2022, bioRxiv.
[8] Anna L. Brown,et al. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A , 2022, Nature.
[9] L. Petrucelli,et al. Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations , 2021, Brain : a journal of neurology.
[10] A. Jeans,et al. Friend or Foe? The Varied Faces of Homeostatic Synaptic Plasticity in Neurodegenerative Disease , 2021, Frontiers in Cellular Neuroscience.
[11] Cory C. Funk,et al. Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions , 2021, The Journal of clinical investigation.
[12] N. Huber,et al. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches , 2021, Molecular Psychiatry.
[13] S. Müller. Managing stress granule disassembly with ubiquitin and its cousin , 2021, Signal Transduction and Targeted Therapy.
[14] T. Raj,et al. Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions , 2021, Acta Neuropathologica.
[15] Evan Z. Macosko,et al. Comparative cellular analysis of motor cortex in human, marmoset and mouse , 2021, Nature.
[16] Xiaochen Bo,et al. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data , 2021, Innovation.
[17] M. Strong,et al. The Integral Role of RNA in Stress Granule Formation and Function , 2021, Frontiers in Cell and Developmental Biology.
[18] R. Rissman,et al. Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression , 2021, bioRxiv.
[19] L. Petrucelli,et al. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau , 2021, Proceedings of the National Academy of Sciences.
[20] S. Haggarty,et al. Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation , 2021, bioRxiv.
[21] Cory C. Funk,et al. Conserved Architecture of Brain Transcriptome Changes between Alzheimer’s Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions , 2021, bioRxiv.
[22] D. Komander,et al. Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities , 2021, Cell Death & Differentiation.
[23] C. Blauwendraat,et al. A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes , 2020, bioRxiv.
[24] Juan I. Young,et al. Epigenome-wide meta-analysis of DNA methylation differences in prefrontal cortex implicates the immune processes in Alzheimer’s disease , 2020, Nature Communications.
[25] G. Carpentier,et al. 3-O-sulfated heparan sulfate interactors target synaptic adhesion molecules from neonatal mouse brain and inhibit neural activity and synaptogenesis in vitro , 2020, Scientific Reports.
[26] M. Larsen,et al. Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia , 2020, Molecular Brain.
[27] Min Su,et al. The functions and mechanisms of prefoldin complex and prefoldin-subunits , 2020, Cell & Bioscience.
[28] M. Larsen,et al. Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia , 2020, Molecular Brain.
[29] W. Heywood,et al. Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer’s disease , 2020, Brain pathology.
[30] Alan J. Thomas,et al. A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex , 2020, Nature Communications.
[31] Memory,et al. Shared , 2020, Definitions.
[32] C. van Broeckhoven,et al. Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum , 2020, Neurobiology of Disease.
[33] Gerta Rücker,et al. How to perform a meta-analysis with R: a practical tutorial , 2019, Evidence-Based Mental Health.
[34] R. Balázs,et al. White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy , 2019, Acta Neuropathologica.
[35] S. Schoch,et al. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA–protein network and RNA granules , 2019, Journal of Cell Science.
[36] Manolis Kellis,et al. Single-cell transcriptomic analysis of Alzheimer’s disease , 2019, Nature.
[37] B. Borroni,et al. Toward a Glutamate Hypothesis of Frontotemporal Dementia , 2019, Front. Neurosci..
[38] Cory C. Funk,et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy , 2018, Acta Neuropathologica.
[39] Ashley R. Jones,et al. Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases , 2018, Molecular Neurodegeneration.
[40] D. Dickson,et al. Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1 , 2018, Nature Communications.
[41] K. Blennow,et al. The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease , 2018, Acta neuropathologica communications.
[42] G. Schellenberg,et al. Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci , 2018, Molecular Neurodegeneration.
[43] Shuo-Chien Ling. Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions , 2018, Neural plasticity.
[44] S. Gygi,et al. OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling. , 2018, Molecular cell.
[45] J. Rowe,et al. Neurotransmitter deficits from frontotemporal lobar degeneration , 2018, Brain : a journal of neurology.
[46] Yuan Tian,et al. ChAMP: updated methylation analysis pipeline for Illumina BeadChips , 2017, Bioinform..
[47] John Hardy,et al. An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks , 2017, BMC Systems Biology.
[48] A. Hyman,et al. An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function , 2017, The EMBO journal.
[49] Anders M. Dale,et al. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia , 2017, Acta Neuropathologica.
[50] Qi Ding,et al. Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model , 2017, Nature Communications.
[51] Andrew D. Rouillard,et al. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins , 2016, Database J. Biol. Databases Curation.
[52] T. Timmusk,et al. Regulation of different human NFAT isoforms by neuronal activity , 2016, Journal of neurochemistry.
[53] Seth G. N. Grant,et al. Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment , 2016, Front. Neurosci..
[54] S. Mead,et al. Review: An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations , 2015, Neuropathology and applied neurobiology.
[55] M. Ehlers,et al. Organization of TNIK in dendritic spines , 2015, The Journal of comparative neurology.
[56] J. Sweatt,et al. DNA methylation regulates neuronal glutamatergic synaptic scaling , 2015, Science Signaling.
[57] Murray Grossman,et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy , 2015, Nature Communications.
[58] N. Mosammaparast,et al. Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase , 2015, The EMBO journal.
[59] Gang Yu,et al. The function of RNA-binding proteins at the synapse: implications for neurodegeneration , 2015, Cellular and Molecular Life Sciences.
[60] F. Lamari,et al. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. , 2015, Brain : a journal of neurology.
[61] M. Grossman,et al. C9orf72 promoter hypermethylation is neuroprotective , 2015, Neurology.
[62] S. Linnarsson,et al. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq , 2015, Science.
[63] S. Sorbi,et al. The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients , 2015, Acta Neuropathologica.
[64] Matthew E. Ritchie,et al. limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.
[65] Alexander Gerhard,et al. Frontotemporal dementia and its subtypes: a genome-wide association study , 2014, The Lancet Neurology.
[66] Rafael A. Irizarry,et al. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays , 2014, Bioinform..
[67] N. Danbolt,et al. Glutamate as a neurotransmitter in the healthy brain , 2014, Journal of Neural Transmission.
[68] P. R. Elliott,et al. OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis , 2013, Cell.
[69] Nathan D. VanderKraats,et al. Discovering high-resolution patterns of differential DNA methylation that correlate with gene expression changes , 2013, Nucleic acids research.
[70] Ibrahim Osman Adam,et al. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination. , 2013, The New England journal of medicine.
[71] C. Plass,et al. Promoter DNA methylation regulates progranulin expression and is altered in FTLD , 2013, Acta neuropathologica communications.
[72] M. Maeda,et al. Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates. , 2013, Biochemistry.
[73] A. Aulas,et al. Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP , 2012, Molecular Neurodegeneration.
[74] L. Saksida,et al. TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function , 2012, The Journal of Neuroscience.
[75] C. Gross,et al. Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation , 2012, The Journal of Neuroscience.
[76] A. Hayashi‐Takagi,et al. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function , 2011, Molecular Psychiatry.
[77] R. Murray,et al. Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder , 2011, Human molecular genetics.
[78] Nick C Fox,et al. A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies. , 2011, Brain : a journal of neurology.
[79] M. Kabani,et al. Hsc70 Protein Interaction with Soluble and Fibrillar α-Synuclein* , 2011, The Journal of Biological Chemistry.
[80] J. Bell,et al. A Genome-Wide Study of DNA Methylation Patterns and Gene Expression Levels in Multiple Human and Chimpanzee Tissues , 2011, PLoS genetics.
[81] Rui Luo,et al. Is My Network Module Preserved and Reproducible? , 2011, PLoS Comput. Biol..
[82] Xiao Zhang,et al. Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis , 2010, BMC Bioinformatics.
[83] R. Huganir,et al. MINK and TNIK Differentially Act on Rap2-Mediated Signal Transduction to Regulate Neuronal Structure and AMPA Receptor Function , 2010, The Journal of Neuroscience.
[84] R. Parker,et al. Eukaryotic stress granules: the ins and outs of translation. , 2009, Molecular cell.
[85] S. Horvath,et al. WGCNA: an R package for weighted correlation network analysis , 2008, BMC Bioinformatics.
[86] J. Trojanowski,et al. Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly. , 2008, Biochemistry.
[87] J. Schneider,et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration , 2007, Acta Neuropathologica.
[88] A. Lees,et al. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. , 2007, Brain : a journal of neurology.
[89] Allan R. Jones,et al. Genome-wide atlas of gene expression in the adult mouse brain , 2007, Nature.
[90] Hui Zhou,et al. Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates. , 2006, Journal of molecular biology.
[91] Bruce L. Miller,et al. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis , 2006, Science.
[92] Richard Paylor,et al. Dynamic Translational and Proteasomal Regulation of Fragile X Mental Retardation Protein Controls mGluR-Dependent Long-Term Depression , 2006, Neuron.
[93] J. Neuhaus,et al. Comparison of family histories in FTLD subtypes and related tauopathies , 2005, Neurology.
[94] Xingyao Wu,et al. GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria. , 2005, Human molecular genetics.
[95] J. Kril,et al. Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. , 2003, Brain : a journal of neurology.
[96] Kenneth S Kosik,et al. Neuronal RNA Granules A Link between RNA Localization and Stimulation-Dependent Translation , 2001, Neuron.
[97] I. Ferrer. Neurons and Their Dendrites in Frontotemporal Dementia , 1999, Dementia and Geriatric Cognitive Disorders.
[98] T. Bliss,et al. A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.
[99] D. Linzer,et al. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter , 1990, Molecular and cellular biology.
[100] L. Voronin,et al. Long-term potentiation in the hippocampus , 1983, Neuroscience.
[101] H. Abdul,et al. NFATs and Alzheimer's Disease. , 2010, Molecular and cellular pharmacology.
[102] Andrew E. Jaffe,et al. Bioinformatics Applications Note Gene Expression the Sva Package for Removing Batch Effects and Other Unwanted Variation in High-throughput Experiments , 2022 .