Colorimetric sensor array based on gold nanoparticles and amino acids for identification of toxic metal ions in water.

A facile colorimetric sensor array for detection of multiple toxic heavy metal ions (Hg(2+), Cd(2+), Fe(3+), Pb(2+), Al(3+), Cu(2+), and Cr(3+)) in water is demonstrated using 11-mercaptoundecanoic acid (MUA)-capped gold nanoparticles (AuNPs) and five amino acids (lysine, cysteine, histidine, tyrosine, and arginine). The presence of amino acids (which have functional groups that can form complexes with metal ions and MUA) regulates the aggregation of MUA-capped particles; it can either enhance or diminish the particle aggregation. The combinatorial colorimetric response of all channels of the sensor array (i.e., color change in each of AuNP and amino acid couples) enables naked-eye discrimination of all of the metal ions tested in this study with excellent selectivity.

[1]  Cuiping Han,et al.  Selective and efficient magnetic separation of Pb2+ via gold nanoparticle-based visual binding enrichment. , 2010, Chemical communications.

[2]  J. Dutta,et al.  Chitosan Capped Colloidal Gold Nanoparticles for Sensing Zinc Ions in Water , 2012 .

[3]  Longhua Guo,et al.  Logic gates for multiplexed analysis of Hg2+ and Ag+. , 2012, The Analyst.

[4]  Chaoxiong Ma,et al.  Surface-enhanced Raman scattering study of the kinetics of self-assembly of carboxylate-terminated n-alkanethiols on silver. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[5]  M. Bayindir,et al.  Smelling in chemically complex environments: an optofluidic Bragg fiber array for differentiation of methanol adulterated beverages. , 2013, Analytical chemistry.

[6]  Joseph T. Hupp,et al.  Gold Nanoparticle-Based Sensing of “Spectroscopically Silent” Heavy Metal Ions , 2001 .

[7]  Kenneth S Suslick,et al.  Colorimetric detection and identification of natural and artificial sweeteners. , 2009, Analytical chemistry.

[8]  Tingting Wang,et al.  Colorimetric detection of Pb2+ using glutathione functionalized gold nanoparticles. , 2010, ACS applied materials & interfaces.

[9]  Z. Havlas,et al.  Theoretical Studies of Metal Ion Selectivity. 1. DFT Calculations of Interaction Energies of Amino Acid Side Chains with Selected Transition Metal Ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, and Hg2+) , 2000 .

[10]  Sarit S. Agasti,et al.  Gold nanoparticles in chemical and biological sensing. , 2012, Chemical reviews.

[11]  D. Fernig,et al.  Determination of size and concentration of gold nanoparticles from UV-vis spectra. , 2007, Analytical chemistry.

[12]  Zhaopeng Chen,et al.  Blue-to-red colorimetric sensing strategy for Hg²⁺ and Ag⁺ via redox-regulated surface chemistry of gold nanoparticles. , 2011, ACS applied materials & interfaces.

[13]  Wenting Zhi,et al.  Cationic polymers and aptamers mediated aggregation of gold nanoparticles for the colorimetric detection of arsenic(III) in aqueous solution. , 2012, Chemical communications.

[14]  Hong-Wei Li,et al.  Selective detection of trace Cr3+ in aqueous solution by using 5,5'-dithiobis (2-nitrobenzoic acid)-modified gold nanoparticles. , 2009, ACS applied materials & interfaces.

[15]  Hong-Soo Kim,et al.  Single-step multiplex detection of toxic metal ions by Au nanowires-on-chip sensor using reporter elimination. , 2012, Lab on a chip.

[16]  J. Cronin,et al.  The resonant mirror: a novel optical biosensor for direct sensing of biomolecular interactions Part I: Principle of operation and associated instrumentation , 1992 .

[17]  Laszlo Magos,et al.  The toxicology of mercury--current exposures and clinical manifestations. , 2003, The New England journal of medicine.

[18]  A. J. Nijdam,et al.  Small molecule- and amino acid-induced aggregation of gold nanoparticles. , 2013, Langmuir : the ACS journal of surfaces and colloids.

[19]  Chad A Mirkin,et al.  Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles. , 2007, Angewandte Chemie.

[20]  B Mattiasson,et al.  Detection of heavy metal ions at femtomolar levels using protein-based biosensors. , 1998, Analytical chemistry.

[21]  D. MubarakAli,et al.  Naked eye sensing of toxic metal ions in aqueous medium using thiophene‐based ligands and its application in living cells , 2014, Journal of molecular recognition : JMR.

[22]  A. Denizli,et al.  Lysine-promoted colorimetric response of gold nanoparticles: a simple assay for ultrasensitive mercury(II) detection. , 2014, Analytical chemistry.

[23]  Joseph M Slocik,et al.  Colorimetric response of peptide-functionalized gold nanoparticles to metal ions. , 2008, Small.