A role for Rho in receptor- and G protein-stimulated phospholipase C Reduction in phosphatidylinositol 4,5-bisphosphate by Clostridium difficile toxin B

[1]  K. Jakobs,et al.  Differential calcium signalling by m2 and m3 muscarinic acetylcholine receptors in a single cell type , 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

[2]  M. Sauerborn,et al.  Comparative sequence analysis of theClostridium difficile toxins A and B , 1992, Molecular and General Genetics MGG.

[3]  K. Jakobs,et al.  Inhibition of Receptor Signaling to Phospholipase D by Clostridium difficile Toxin B , 1996, The Journal of Biological Chemistry.

[4]  T. Wieland,et al.  Rapid and Persistent Desensitization of m3 Muscarinic Acetylcholine Receptor-stimulated Phospholipase D , 1995, The Journal of Biological Chemistry.

[5]  P. Janmey,et al.  Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets , 1995, Cell.

[6]  S. Cockcroft,et al.  Phosphatidylinositol transfer protein dictates the rate of inositol trisphosphate production by promoting the synthesis of PIP2 , 1995, Current Biology.

[7]  M. Wilm,et al.  The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins(*) , 1995, The Journal of Biological Chemistry.

[8]  M. Mann,et al.  Glucosylation of Rho proteins by Clostridium difficile toxin B , 1995, Nature.

[9]  L. Cantley,et al.  Signal transduction and membrane traffic: The PITP/phosphoinositide connection , 1995, Cell.

[10]  L. Cantley,et al.  Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells (*) , 1995, The Journal of Biological Chemistry.

[11]  C. Zuker,et al.  Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase , 1995, Nature.

[12]  S. Rhee,et al.  Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes. , 1995, Current opinion in cell biology.

[13]  N. Divecha,et al.  Phospholipid signaling , 1995, Cell.

[14]  L. Chong,et al.  The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells , 1994, Cell.

[15]  K. Jakobs,et al.  Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation. , 1994, European journal of biochemistry.

[16]  L. Cantley,et al.  Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. , 1994, The Journal of biological chemistry.

[17]  T. Wieland,et al.  Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11. , 1994, Molecular pharmacology.

[18]  K. Aktories,et al.  Clostridium difficile toxin B acts on the GTP-binding protein Rho. , 1994, The Journal of biological chemistry.

[19]  R. Burgoyne Phosphoinositides in vesicular traffic. , 1994, Trends in biochemical sciences.

[20]  P. Janmey,et al.  Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. , 1994, Annual review of physiology.

[21]  P C Sternweis,et al.  Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits. , 1993, The Journal of biological chemistry.

[22]  M. Berridge Inositol trisphosphate and calcium signalling , 1993, Nature.

[23]  K. Aktories,et al.  GTPases and Actin as Targets for Bacterial Toxins , 1993 .

[24]  E. Ross,et al.  Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1. , 1992, The Journal of biological chemistry.

[25]  K. Jakobs,et al.  Guanosine 5'-[gamma-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes. Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint. , 1990, The Biochemical journal.

[26]  A. Hall,et al.  Microinjection of recombinant p21rho induces rapid changes in cell morphology , 1990, The Journal of cell biology.

[27]  L. Cantley,et al.  Phosphoinositide kinases. , 1990, Biochemistry.

[28]  A. T. Young,et al.  Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. , 1989, The Journal of biological chemistry.

[29]  D. Aunis,et al.  Mechanism of action of Clostridium difficile toxin B: role of external medium and cytoskeletal organization in intoxicated cells. , 1989, European journal of cell biology.

[30]  A. Ashkenazi,et al.  Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes , 1988, Nature.

[31]  C. von Eichel-Streiber,et al.  Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related. , 1987, Microbial pathogenesis.