Inhibitory Control in Children with Autism Spectrum Disorder

Impairments in executive abilities such as cognitive flexibility have been identified in individuals with autism spectrum disorder (ASD). It remains unclear, however, whether such individuals also experience impairments in another executive ability: inhibitory control. In the present study, we administered three inhibitory tasks to 18 children with ASD, 23 siblings of children with ASD, and 25 typically developing children. After controlling for individual differences in age, overall IQ, and processing speed, children with ASD demonstrated impaired performance on two of the three inhibitory tasks. Results suggest that children with ASD experience circumscribed deficits in some but not all aspects of inhibitory control. More generally, the findings underscore the importance of using multiple measures to assess a putative single cognitive ability.

[1]  B. Pennington,et al.  Executive functions in young children with autism. , 1999, Child development.

[2]  Herbert Roeyers,et al.  Event-Rate Manipulation and its Effect on Arousal Modulation and Response Inhibition in Adults With High Functioning Autism , 2004, Journal of clinical and experimental neuropsychology.

[3]  Karl J. Friston,et al.  Investigating individual differences in brain abnormalities in autism. , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[4]  C. Carter,et al.  Abnormal processing of irrelevant information in chronic schizophrenia: Selective enhancement of stroop facilitation , 1992, Psychiatry Research.

[5]  B. J. Casey,et al.  Evidence for a mechanistic model of cognitive control , 2001, Clinical Neuroscience Research.

[6]  M. Leboyer,et al.  Towards a cognitive phenotype for autism: increased prevalence of executive dysfunction and superior spatial span amongst siblings of children with autism. , 1999, Journal of child psychology and psychiatry, and allied disciplines.

[7]  P H Schiller,et al.  Developmental study of color-word interference. , 1966, Journal of experimental psychology.

[8]  S. M. Carlson Executive function in context: development, measurement, theory, and experience. , 2003, Monographs of the Society for Research in Child Development.

[9]  J. Stroop Studies of interference in serial verbal reactions. , 1992 .

[10]  E. Bullmore,et al.  Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. , 1999, The American journal of psychiatry.

[11]  J. Russell Autism as an executive disorder , 1997 .

[12]  D. Trauner,et al.  Brief Report: Attention Differences in Asperger Syndrome , 2002, Journal of autism and developmental disorders.

[13]  Insel Tr Obsessive-compulsive disorder: a neuroethological perspective. , 1988 .

[14]  C. Eriksen,et al.  Effects of noise letters upon the identification of a target letter in a nonsearch task , 1974 .

[15]  Colin M. Macleod Half a century of research on the Stroop effect: an integrative review. , 1991, Psychological bulletin.

[16]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[17]  R. Asarnow,et al.  Children with a schizopherenic disorder: Neurobehavioral studies , 2005, European Archives of Psychiatry and Clinical Neuroscience.

[18]  N. Minshew,et al.  Neocortical system abnormalities in autism: An fMRI study of spatial working memory , 2002, Neurology.

[19]  Herbert Roeyers,et al.  How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[20]  W. Perlstein,et al.  The Stroop task and attention deficits in schizophrenia: a critical evaluation of card and single-trial Stroop methodologies. , 1998, Neuropsychology.

[21]  David L. Strayer,et al.  Executive function abilities in autism and Tourette syndrome: an information processing approach. , 1994, Journal of child psychology and psychiatry, and allied disciplines.

[22]  C. Eriksen,et al.  The flankers task and response competition: A useful tool for investigating a variety of cognitive problems , 1995 .

[23]  H. Werner,et al.  Interference effects of Stroop color-word test in childhood, adulthood, and aging. , 1962, The Journal of genetic psychology.

[24]  R. Rothermel,et al.  Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys , 1997, Annals of neurology.

[25]  S. Ozonoff,et al.  Brief Report: Specific Executive Function Profiles in Three Neurodevelopmental Disorders , 1999, Journal of autism and developmental disorders.

[26]  E. Drewe Go - No Go Learning After Frontal Lobe Lesions in Humans , 1975, Cortex.

[27]  R. Abrams,et al.  Inhibitory control following perinatal brain injury. , 2003, Neuropsychology.

[28]  T. Carr,et al.  Inhibitory Processes in Attention, Memory and Language , 1994 .

[29]  Desiree A. White,et al.  Inhibitory Control Across the Life Span , 2001 .

[30]  J T Enns,et al.  A developmental study of filtering in visual attention. , 1989, Child development.

[31]  J. Sergeant,et al.  Inhibition in ADHD, aggressive, and anxious children: A biologically based model of child psychopathology , 1996, Journal of abnormal child psychology.

[32]  E. Hill Evaluating the theory of executive dysfunction in autism , 2004 .

[33]  J. Cummings,et al.  Anatomic and Behavioral Aspects of Frontal‐Subcortical Circuits a , 1995, Annals of the New York Academy of Sciences.

[34]  B. Pennington,et al.  Neuropsychology of early-treated phenylketonuria: specific executive function deficits. , 1990, Child development.

[35]  E. Hill Executive dysfunction in autism , 2004, Trends in Cognitive Sciences.

[36]  A L Brody,et al.  Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder , 1998, British Journal of Psychiatry.

[37]  J. Fletcher,et al.  Developmental changes in performance on tests of purported frontal lobe functioning , 1991 .

[38]  B. J. Casey,et al.  Clinical, imaging, lesion, and genetic approaches toward a model of cognitive control. , 2002, Developmental psychobiology.

[39]  F. N. Dempster,et al.  The rise and fall of the inhibitory mechanism: Toward a unified theory of cognitive development and aging , 1992 .

[40]  N. Minshew,et al.  Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism , 1999, Neurology.

[41]  S. Bryson,et al.  Comprehension of concrete and abstract words in autistic children , 1990, Journal of autism and developmental disorders.

[42]  R. Abrams,et al.  Inhibitory Control in Children With Phenylketonuria , 2006, Developmental neuropsychology.

[43]  G. Logan On the ability to inhibit thought and action , 1984 .

[44]  Michael Petrides,et al.  Behavioural effects of frontal-lobe lesions in man , 1984, Trends in Neurosciences.

[45]  David L. Strayer,et al.  Inhibitory Function in Nonretarded Children with Autism , 1997, Journal of autism and developmental disorders.

[46]  T. Uema,et al.  Abnormal regional cerebral blood flow in childhood autism. , 2000, Brain : a journal of neurology.

[47]  Y. Miyashita,et al.  The Wisconsin Card Sorting Test , 2022 .

[48]  J. Rapoport,et al.  Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study. , 1999, Archives of general psychiatry.

[49]  A. Diamond,et al.  Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. , 1991, Monographs of the Society for Research in Child Development.

[50]  A. Diamond,et al.  An animal model of early-treated PKU , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[51]  Jacob A. Burack,et al.  Intact Covert Orienting to Peripheral Cues Among Children with Autism , 2004, Journal of autism and developmental disorders.

[52]  W. H. Burke,et al.  Improving executive function disorders in brain-injured clients. , 1991, Brain injury.

[53]  J M Farnham,et al.  Can standard measures identify subclinical markers of autism? , 1993, Journal of autism and developmental disorders.

[54]  Donald T. Stuss,et al.  Biological and psychological development of executive functions , 1992, Brain and Cognition.

[55]  J. Brock,et al.  To Match or Not to Match? Methodological Issues in Autism-Related Research , 2004, Journal of autism and developmental disorders.

[56]  Lynn Hasher,et al.  Working Memory, Comprehension, and Aging: A Review and a New View , 1988 .

[57]  Joyce L. Sichel,et al.  The color-word interference test: The effects of varied color-word combinations upon verbal response latency. , 1969 .

[58]  Y. Samson,et al.  Delayed maturation of the frontal cortex in childhood autism. , 1995, The American journal of psychiatry.

[59]  B. J. Casey,et al.  Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[60]  D. Cohen,et al.  Nongenetic factors in Gilles de la Tourette's syndrome. , 1987, Archives of general psychiatry.