Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players

[1]  C. Liu,et al.  The TERT locus genotypes of rs2736100-CC/CA and rs2736098-AA predict shorter survival in renal cell carcinoma. , 2019, Urologic oncology.

[2]  Winnie S. Liang,et al.  A virome-wide clonal integration analysis platform for discovering cancer viral etiology , 2019, Genome research.

[3]  J. Shay,et al.  Telomeres and telomerase: three decades of progress , 2019, Nature Reviews Genetics.

[4]  F. Westermann,et al.  A mechanistic classification of clinical phenotypes in neuroblastoma , 2018, Science.

[5]  S. Imbeaud,et al.  Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress , 2018, Nature Communications.

[6]  Trevor J Pugh,et al.  DNA hypermethylation within TERT promoter upregulates TERT expression in cancer , 2018, The Journal of clinical investigation.

[7]  T. Ekström,et al.  Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma. , 2018, Cancer letters.

[8]  C. Larsson,et al.  GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression , 2018, Oncogene.

[9]  Jun S. Song,et al.  Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. , 2018, Cancer cell.

[10]  Julie M. Batten,et al.  DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome , 2018, Acta Neuropathologica.

[11]  V. Gladyshev,et al.  Mechanisms of cancer resistance in long-lived mammals , 2018, Nature Reviews Cancer.

[12]  Mazen A. Juratli,et al.  TERT Promoter Mutation Detection in Cell-Free Tumor-Derived DNA in Patients with IDH Wild-Type Glioblastomas: A Pilot Prospective Study , 2018, Clinical Cancer Research.

[13]  R. McLendon,et al.  The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma , 2018, Nature Communications.

[14]  O. Larsson,et al.  Telomerase promoter mutations and copy number alterations in solitary fibrous tumours , 2018, Journal of Clinical Pathology.

[15]  P. A. Futreal,et al.  Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal , 2018, Cell.

[16]  M. Mahajan,et al.  A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma , 2018, Oncogene.

[17]  C. Larsson,et al.  Telomerase reverse transcriptase promoter hypermethylation is associated with metastatic disease in abdominal paraganglioma , 2018, Clinical endocrinology.

[18]  C. Larsson,et al.  TERT Promoter Hypermethylation in Gastrointestinal Cancer: A Potential Stool Biomarker. , 2017, The oncologist.

[19]  X. Darzacq,et al.  Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism , 2017, Science.

[20]  J. Yoon,et al.  Human Telomerase Reverse Transcriptase (hTERT) Positively Regulates 26S Proteasome Activity , 2017, Journal of cellular physiology.

[21]  Kai-Ping Chang,et al.  Prevalence of promoter mutations in the TERT gene in oral cavity squamous cell carcinoma , 2017, Head & neck.

[22]  Dawei Xu,et al.  WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem Cells. , 2017, Cancer research.

[23]  Michael C. Ostrowski,et al.  The ETS family of oncogenic transcription factors in solid tumours , 2017, Nature Reviews Cancer.

[24]  Richard C. Wang,et al.  Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations , 2017, The Journal of clinical investigation.

[25]  Dawei Xu,et al.  The TERT promoter mutation incidence is modified by germline TERT rs2736098 and rs2736100 polymorphisms in hepatocellular carcinoma , 2017, Oncotarget.

[26]  Xin Hu,et al.  Systematic analysis of telomere length and somatic alterations in 31 cancer types , 2017, Nature Genetics.

[27]  J. Shay,et al.  Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer , 2016, PLoS biology.

[28]  L. Saft,et al.  TERT rs2736100 genotypes are associated with differential risk of myeloproliferative neoplasms in Swedish and Chinese male patient populations , 2016, Annals of Hematology.

[29]  Dawei Xu,et al.  Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications , 2016, Genes.

[30]  J. Shay,et al.  hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor , 2016, Nucleic acids research.

[31]  K. Aldape,et al.  TERT Promoter Mutations and Risk of Recurrence in Meningioma. , 2016, Journal of the National Cancer Institute.

[32]  Xiaoming Li,et al.  Association of Telomerase Reverse Transcriptase Promoter Mutations with the Prognosis of Glioma Patients: a Meta-Analysis , 2016, Molecular Neurobiology.

[33]  Jun S. Song,et al.  Understanding TERT Promoter Mutations: A Common Path to Immortality , 2016, Molecular Cancer Research.

[34]  Bert Vogelstein,et al.  The Path to Cancer --Three Strikes and You're Out. , 2015, The New England journal of medicine.

[35]  D. Zwijnenburg,et al.  Abstract PR06: TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors , 2016 .

[36]  B. Vogelstein,et al.  Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers , 2015, Genes & development.

[37]  Y. Maida,et al.  Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase , 2015, Cancer science.

[38]  Simon C Watkins,et al.  Telomerase activation by genomic rearrangements in high-risk neuroblastoma , 2015, Nature.

[39]  F. He,et al.  hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation , 2015, Gut.

[40]  Jessica Zucman-Rossi,et al.  Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas , 2015, Nature Genetics.

[41]  Z. Cai,et al.  The C228T mutation of TERT promoter frequently occurs in bladder cancer stem cells and contributes to tumorigenesis of bladder cancer , 2015, Oncotarget.

[42]  J. Boyle,et al.  Cancer-associated TERT promoter mutations abrogate telomerase silencing , 2015, eLife.

[43]  Chibo Hong,et al.  The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer , 2015, Science.

[44]  C. Liu,et al.  TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer. , 2015, The oncologist.

[45]  Christophe Simon,et al.  Telomerase Reverse Transcriptase Regulates microRNAs , 2015, International journal of molecular sciences.

[46]  G. Saretzki Extra-telomeric functions of human telomerase: cancer, mitochondria and oxidative stress. , 2014, Current pharmaceutical design.

[47]  C. Larsson,et al.  The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas , 2014, Oncogene.

[48]  V. Dosenko,et al.  Silencing of TERT decreases levels of miR‐1, miR‐21, miR‐29a and miR‐208a in cardiomyocytes , 2014, Cell biochemistry and function.

[49]  J. Shay,et al.  Alternative splicing regulation of telomerase: a new paradigm? , 2014, Trends in genetics : TIG.

[50]  C. Larsson,et al.  TERT promoter mutations and gene amplification: Promoting TERT expression in Merkel cell carcinoma , 2014, Oncotarget.

[51]  Lawrence A. Donehower,et al.  The somatic genomic landscape of chromophobe renal cell carcinoma. , 2014, Cancer cell.

[52]  J. Bishop,et al.  BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[53]  C. Larsson,et al.  Telomerase-Dependent and Independent Telomere Maintenance and its Clinical Implications in Medullary Thyroid Carcinoma , 2014, The Journal of clinical endocrinology and metabolism.

[54]  Robert Tjian,et al.  Looping Back to Leap Forward: Transcription Enters a New Era , 2014, Cell.

[55]  M. Knowles,et al.  Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine. , 2014, European urology.

[56]  Junzhi Zhou,et al.  Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF‐κB‐dependent transcription , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[57]  J. Shay,et al.  Endoplasmic reticulum stress activates telomerase , 2013, Aging cell.

[58]  D. Haussler,et al.  The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.

[59]  J. Yang,et al.  Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells , 2013, Oncogene.

[60]  David T. W. Jones,et al.  Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. , 2013, The Lancet. Oncology.

[61]  C. Bokemeyer,et al.  Molecular characterization of chromosomal band 5p15.33: a recurrent breakpoint region in mantle cell lymphoma involving the TERT-CLPTM1L locus. , 2013, Leukemia research.

[62]  R. Janzer,et al.  Methylation of the hTERT Promoter: A Novel Cancer Biomarker for Leptomeningeal Metastasis Detection in Cerebrospinal Fluids , 2013, Clinical Cancer Research.

[63]  D. Schadendorf,et al.  TERT Promoter Mutations in Familial and Sporadic Melanoma , 2013, Science.

[64]  Lynda Chin,et al.  Highly Recurrent TERT Promoter Mutations in Human Melanoma , 2013, Science.

[65]  Angela M. Liu,et al.  Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma , 2012, Nature Genetics.

[66]  M. Pagel,et al.  Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination , 2011, Aging cell.

[67]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[68]  T. Tollefsbol,et al.  Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[69]  R. Janzer,et al.  Abstract 4931: Methylation of the hTERT promoter: a potential cancer biomarker for leptomeningeal metastasis detection in cerebrospinal fluids , 2010 .

[70]  S. Grigoryev,et al.  Rearrangement of upstream sequences of the hTERT gene during cellular immortalization , 2009, Genes, chromosomes & cancer.

[71]  M. Björkholm,et al.  FoxM1 is up‐regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27kip1 , 2009, The Journal of pathology.

[72]  Timothy D. Veenstra,et al.  Telomerase modulates Wnt signalling by association with target gene chromatin , 2009, Nature.

[73]  S. Kyo,et al.  Activation of telomerase by human cytomegalovirus. , 2009, Journal of the National Cancer Institute.

[74]  A. Pinto,et al.  Bone morphogenetic protein-7 inhibits telomerase activity, telomere maintenance, and cervical tumor growth. , 2008, Cancer research.

[75]  W. Duan,et al.  Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc* , 2008, Journal of Biological Chemistry.

[76]  C. Liu,et al.  Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. , 2008, Cancer letters.

[77]  M. Bellon,et al.  Regulation of telomerase and telomeres: human tumor viruses take control. , 2008, Journal of the National Cancer Institute.

[78]  S. Kyo,et al.  The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3. , 2007, Cancer research.

[79]  C. Liu,et al.  Mitogen-Activated Protein Kinase Cascade-Mediated Histone H3 Phosphorylation Is Critical for Telomerase Reverse Transcriptase Expression/Telomerase Activation Induced by Proliferation , 2006, Molecular and Cellular Biology.

[80]  P. Ekman,et al.  Differential Expression of Full-length Telomerase Reverse Transcriptase mRNA and Telomerase Activity between Normal and Malignant Renal Tissues , 2005, Clinical Cancer Research.

[81]  W. Hahn,et al.  The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[82]  T. Kiyono,et al.  Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex. , 2004, Genes & development.

[83]  L. Huang,et al.  HIF‐1α induces cell cycle arrest by functionally counteracting Myc , 2004 .

[84]  J. Ruppert,et al.  Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements. , 2003, Gene.

[85]  Yoshiki Murakami,et al.  Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene , 2003, Oncogene.

[86]  E. Blennow,et al.  Deletion of the telomerase reverse transcriptase gene and haploinsufficiency of telomere maintenance in Cri du chat syndrome. , 2003, American Journal of Human Genetics.

[87]  J F Barrett,et al.  Arsenic inhibition of telomerase transcription leads to genetic instability. , 2001, The Journal of clinical investigation.

[88]  J. Barrett,et al.  cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome. , 2001, Journal of the National Cancer Institute.

[89]  S. Kyo,et al.  Telomerase activation by histone deacetylase inhibitor in normal cells. , 2001, Nucleic acids research.

[90]  Nikita Popov,et al.  Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[91]  A. Zetterberg,et al.  Frequent amplification of the telomerase reverse transcriptase gene in human tumors. , 2000, Cancer research.

[92]  Robert A. Weinberg,et al.  Creation of human tumour cells with defined genetic elements , 1999, Nature.

[93]  M. Yutsudo,et al.  Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. , 1999, Cancer research.

[94]  G. Hannon,et al.  Myc activates telomerase. , 1998, Genes & development.

[95]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[96]  Keiko Hiyama,et al.  Correlating telomerase activity levels with human neuroblastoma outcomes , 1995, Nature Medicine.

[97]  Daniel L. Cameron,et al.  TERT structural rearrangements in metastatic pheochromocytomas. , 2018, Endocrine-related cancer.

[98]  J. Barrett,et al.  HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. , 2004, The EMBO journal.

[99]  R. Glasspool,et al.  Activation of telomerase rna gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3. , 2000, Neoplasia.

[100]  Y. Cong,et al.  The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. , 1999, Human molecular genetics.