3, 5, 3′-Triiodothyroacetic acid (TRIAC) is an anti-inflammatory drug that targets toll-like receptor 2

[1]  P. Davis,et al.  Thyroid hormones derivatives reduce proliferation and induce cell death and DNA damage in ovarian cancer , 2017, Scientific Reports.

[2]  Sue-Heui Shieh,et al.  Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice , 2017, Scientific Reports.

[3]  Ming Niu,et al.  Sophocarpine Protects Mice from ConA-Induced Hepatitis via Inhibition of the IFN-Gamma/STAT1 Pathway , 2017, Front. Pharmacol..

[4]  Shery Jacob,et al.  A simple practice guide for dose conversion between animals and human , 2016, Journal of basic and clinical pharmacy.

[5]  Shun-cai Zhang,et al.  Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway , 2016, Inflammation.

[6]  G. Gerken,et al.  Higher Thyroid-Stimulating Hormone, Triiodothyronine and Thyroxine Values Are Associated with Better Outcome in Acute Liver Failure , 2015, PloS one.

[7]  F. Tacke,et al.  The concanavalin A model of acute hepatitis in mice , 2015, Laboratory animals.

[8]  Fan Wang,et al.  Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis , 2015, PloS one.

[9]  Yanning Liu,et al.  Emodin Protects Against Concanavalin A-Induced Hepatitis in Mice Through Inhibiting Activation of the p38 MAPK-NF-κB Signaling Pathway , 2015, Cellular Physiology and Biochemistry.

[10]  M. Giordano,et al.  Chronic hepatitis C virus infection and neurological and psychiatric disorders: an overview. , 2015, World journal of gastroenterology.

[11]  J. Choi,et al.  Protective effect of ellagic acid on concanavalin A-induced hepatitis via toll-like receptor and mitogen-activated protein kinase/nuclear factor κB signaling pathways. , 2014, Journal of agricultural and food chemistry.

[12]  Taro Kawai,et al.  Toll-Like Receptor Signaling Pathways , 2014, Front. Immunol..

[13]  S. Ye,et al.  Blocking TLR2 in vivo attenuates experimental hepatitis induced by concanavalin A in mice. , 2014, International immunopharmacology.

[14]  G. Brent,et al.  Thyroid hormone regulation of metabolism. , 2014, Physiological reviews.

[15]  T. Visser,et al.  Tetrac can replace thyroid hormone during brain development in mouse mutants deficient in the thyroid hormone transporter mct8. , 2013, Endocrinology.

[16]  P. Webb,et al.  Thyroid Hormone Analogue Stimulates Keratinocyte Proliferation but Inhibits Cell Differentiation in Epidermis , 2012, International journal of immunopathology and pharmacology.

[17]  R. Casamitjana,et al.  Serum free triiodothyronine (T3) to free thyroxine (T4) ratio in treated central hypothyroidism compared with primary hypothyroidism and euthyroidism. , 2011, Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion.

[18]  Wei Zhang,et al.  Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice. , 2009, Biochemical and biophysical research communications.

[19]  A. Dolganiuc,et al.  Toll‐like receptors 1 and 6 are involved in TLR2‐mediated macrophage activation by hepatitis C virus core and NS3 proteins , 2007, Journal of leukocyte biology.

[20]  A. Sodhi,et al.  Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro. , 2007, International immunopharmacology.

[21]  S. Lewin,et al.  Regulation of Toll‐like receptor‐2 expression in chronic hepatitis B by the precore protein , 2007, Hepatology.

[22]  H. S. Warren,et al.  Toll-like receptors. , 2005, Critical care medicine.

[23]  T. Ashburn,et al.  Drug repositioning: identifying and developing new uses for existing drugs , 2004, Nature Reviews Drug Discovery.

[24]  M. Greenblatt,et al.  A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria , 2004, Science.

[25]  Shizuo Akira,et al.  Toll-like Receptor Signaling* , 2003, Journal of Biological Chemistry.

[26]  B. Beutler,et al.  How we detect microbes and respond to them: the Toll‐like receptors and their transducers , 2003, Journal of leukocyte biology.

[27]  R. Malik,et al.  The relationship between the thyroid gland and the liver. , 2002, QJM : monthly journal of the Association of Physicians.

[28]  G. Chainy,et al.  Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone. , 2001, Biochimica et biophysica acta.

[29]  K. Sasaki,et al.  Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model. , 2000, European Journal of Pharmacology.

[30]  M. Taniguchi,et al.  Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis , 2000, The Journal of experimental medicine.

[31]  A. Dorner,et al.  Interleukin‐11 reduces T‐cell–dependent experimental liver injury in mice , 1999, Hepatology.

[32]  Y. Liaw,et al.  Clinical associations between thyroid and liver diseases , 1995, Journal of gastroenterology and hepatology.

[33]  A. Wendel,et al.  A T cell-dependent experimental liver injury in mice inducible by concanavalin A. , 1992, The Journal of clinical investigation.

[34]  P. Soubrié,et al.  Triiodothyroacetic acid (TRIAC) potentiation of antidepressant-induced reversal of learned helplessness in rats. , 1988, European journal of pharmacology.

[35]  A. R. Cameron,et al.  Depolarization and increased conductance precede superoxide release by concanavalin A-stimulated rat alveolar macrophages. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Macdermott,et al.  Interaction of plant lectins with purified human lymphocyte populations: binding characteristics and kinetics of proliferation. , 1975, Journal of immunology.