3,4-Dihydroquinoxalin-2-one privileged motif: A journey from classical chiral tools based synthesis to modern catalytic enantioselective strategies

[1]  Q. Fan,et al.  Ruthenium-Catalyzed Enantioselective Hydrogenation of Quinoxalinones and Quinazolinones , 2022, Organic Chemistry Frontiers.

[2]  S. Sharma,et al.  Developments in the Catalytic Asymmetric Synthesis of Agrochemicals and Their Synthetic Importance. , 2021, Journal of agricultural and food chemistry.

[3]  Biplob Borah,et al.  Recent advances in the transition-metal-free synthesis of quinoxalines , 2021, RSC advances.

[4]  Qin Yang,et al.  α-Keto Acids as Triggers and Partners for the Synthesis of Quinazolinones, Quinoxalinones, Benzooxazinones, and Benzothiazoles in Water. , 2021, The Journal of organic chemistry.

[5]  A. Mazzanti,et al.  Catalytic Enantioselective Access to Dihydroquinoxalinones via Formal α‐Halo Acyl Halide Synthon in One Pot , 2021, Angewandte Chemie.

[6]  Sándor B. Ötvös,et al.  Continuous flow asymmetric synthesis of chiral active pharmaceutical ingredients and their advanced intermediates , 2021, Green chemistry : an international journal and green chemistry resource : GC.

[7]  D. Dybtsev,et al.  Asymmetric catalysis using metal-organic frameworks , 2021 .

[8]  T. Arai,et al.  Chiral C2-Symmetric Aminomethylbinaphthol as Synergistic Catalyst for Asymmetric Epoxidation of Alkylidenemalononitriles: Easy Access to Chiral Spirooxindoles. , 2021, Organic letters.

[9]  Gu He,et al.  Asymmetric organocatalysis: an enabling technology for medicinal chemistry. , 2021, Chemical Society reviews.

[10]  A. Franz,et al.  Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles , 2021 .

[11]  B. Stoltz,et al.  Recent Advances in Homogeneous Catalysts for the Asymmetric Hydrogenation of Heteroarenes. , 2020, ACS catalysis.

[12]  E. Lenardão,et al.  A niobium-catalyzed coupling reaction of α-keto acids with ortho-phenylenediamines: synthesis of 3-arylquinoxalin-2(1H)-ones , 2019, Green Chemistry.

[13]  S. K. Sartori,et al.  Use of chiral auxiliaries in the asymmetric synthesis of biologically active compounds: A review. , 2019, Chirality.

[14]  C. Vila,et al.  A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones. , 2019, Organic letters.

[15]  Xiangyang Li,et al.  Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives. , 2019, Organic letters.

[16]  Qin Yang,et al.  Enantioselective synthesis of trifluoromethylated dihydroquinoxalinones via palladium-catalyzed hydrogenation , 2019, Organic Chemistry Frontiers.

[17]  T. Terme,et al.  Antitumoral activity of quinoxaline derivatives: A systematic review. , 2019, European journal of medicinal chemistry.

[18]  Thierry Ollevier,et al.  Iron- or Zinc-Mediated Synthetic Approach to Enantiopure Dihydroquinoxalinones , 2018, European Journal of Organic Chemistry.

[19]  A. Calcaterra,et al.  The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds , 2018, Journal of pharmaceutical and biomedical analysis.

[20]  T. Bach,et al.  Iminium and enamine catalysis in enantioselective photochemical reactions , 2017, Chemical Society reviews.

[21]  H. Leek,et al.  Strategy for large-scale isolation of enantiomers in drug discovery. , 2017, Drug discovery today.

[22]  Huibin Zhang,et al.  Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. , 2016, Bioorganic chemistry.

[23]  Claudio Battilocchio,et al.  Enabling Technologies for the Future of Chemical Synthesis , 2016, ACS central science.

[24]  Sara Meninno,et al.  Asymmetric Epoxidation of Alkylidenemalononitriles: Key Step for One-Pot Approach to Enantioenriched 3-Substituted Piperazin-2-ones. , 2015, Organic letters.

[25]  Marie Jung,et al.  Targeting BET bromodomains for cancer treatment. , 2015, Epigenomics.

[26]  Stefan Knapp,et al.  A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction** , 2014, Angewandte Chemie.

[27]  Guigen Li,et al.  Asymmetric Organocatalytic Tandem Cyclization/Transfer Hydrogenation: A Synthetic Strategy for Enantioenriched Nitrogen Heterocycles , 2013 .

[28]  A. Vidal‐Ferran,et al.  [Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C═N-containing heterocycles. , 2013, Organic letters.

[29]  Y. Park,et al.  L-Tartaric Acid as a New Chiral Auxiliary for Asymmetric Synthesis of Piperazinones, Morpholinones, Dihydroquinoxalinones and Dihydrobenzoxazinones , 2012 .

[30]  Wen-Jing Xiao,et al.  Visible-light photoredox catalysis. , 2012, Angewandte Chemie.

[31]  V. Krchňák,et al.  Piperazine amide linker for cyclative cleavage from solid support: traceless synthesis of dihydroquinoxalin-2-ones. , 2012, ACS combinatorial science.

[32]  R. Rios Enantioselective methodologies for the synthesis of spiro compounds. , 2012, Chemical Society reviews.

[33]  Roland Wohlgemuth,et al.  Biocatalysis--key to sustainable industrial chemistry. , 2010, Current opinion in biotechnology.

[34]  T. Nishimura,et al.  A General and Practical Access to Chiral Quinoxalinones with Low Copper‐Catalyst Loading , 2010 .

[35]  Xiaomei Zhang,et al.  The First General, Highly Enantioselective Lewis Base Organo‐ catalyzed Hydrosilylation of Benzoxazinones and Quinoxalinones , 2010 .

[36]  M. Rueping,et al.  The first general, efficient and highly enantioselective reduction of quinoxalines and quinoxalinones. , 2010, Chemistry.

[37]  Y. Park,et al.  (S)-MANDELATE-MEDIATED DYNAMIC KINETIC RESOLUTION OF α-BROMO ESTERS FOR ASYMMETRIC SYNTHESES OF AMINOFLAVONES, DIHYDROQUINOXALINONES AND DIHYDROBENZOXAZINONES , 2009 .

[38]  Ying Guo,et al.  Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors. , 2009, Bioorganic & medicinal chemistry.

[39]  C. Maroun,et al.  Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. , 2009, Bioorganic & medicinal chemistry letters.

[40]  K. Chanda,et al.  Enantioselective synthesis of benzimidazolyl quinoxalinones on soluble polymer support using focused microwave irradiation. , 2009, Journal of combinatorial chemistry.

[41]  S. Hitchcock,et al.  Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists. , 2008, Bioorganic & medicinal chemistry letters.

[42]  S. Denmark,et al.  Lewis base catalysis in organic synthesis. , 2008, Angewandte Chemie.

[43]  Daniel H. Paull,et al.  Catalytic, enantioselective bifunctional inverse electron demand hetero-Diels-Alder reactions of ketene enolates and o-benzoquinone diimides. , 2006, Journal of the American Chemical Society.

[44]  P. Kočovský,et al.  Role of noncovalent interactions in the enantioselective reduction of aromatic ketimines with trichlorosilane. , 2004, Organic letters.

[45]  Chung‐Ming Sun,et al.  Liquid phase synthesis of chiral quinoxalinones by microwave irradiation , 2004 .

[46]  R. Wood,et al.  GW420867X Administered to HIV-1-Infected Patients Alone and in Combination with Lamivudine and Zidovudine , 2001, HIV clinical trials.

[47]  W. DeGrado,et al.  Solid-Phase Synthesis of Benzopiperazinones , 1998 .

[48]  R. Rivero,et al.  SOLID PHASE SYNTHESIS OF 3,4-DISUBSTITUTED-7-CARBAMOYL-1,2,3,4-TETRAHYDROQUINOXALIN-2-ONES , 1997 .

[49]  D. Carter,et al.  Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor. , 1994, Journal of medicinal chemistry.

[50]  T. Durst,et al.  Reaction of (R)-pantolactone esters of alpha-bromoacids with amines a remarkable synthesis of optically active alpha-amino esters , 1993 .

[51]  E. Corey,et al.  A general, catalytic, and enantioselective synthesis of .alpha.-amino acids , 1992 .