Event-related brain potentials during an extended visual recognition memory task depict delayed development of cerebral inhibitory processes among 6-month-old infants with Down syndrome.

Development of cerebral inhibitory processes among individuals with Down syndrome (DS) may be delayed at an early age. In support of this hypothesis, sensory-evoked potentials (EPs) and event-related brain potentials (ERPs) have previously delineated altered habituation to stimuli among infants with DS. The purpose of the current study was to provide extended experience with visual stimuli among 6-month-old infants with and without DS (nDS) to determine if altered ERP and behavioral response decrements would be evident even after repeated presentations of stimuli. An 80/20% oddball paradigm was employed. Infants with DS and nDS were matched according to age and gender. Infants with DS demonstrated significantly larger Nc areas, Nc peak amplitudes, Nc2 areas and, inversely, significantly smaller peak Pb amplitudes when compared to infants nDS. Contrasts of the two study groups were most robust within ERP measures from frontal (Fz) and parietal (Pz) recording sites. Infants with DS also demonstrated a significantly slower decrement of most ERP components with repetitive stimulus experience. Most noteworthy was the observation of little or no decrement of ERP components at Fz among infants with DS. Both infants with DS and nDS demonstrated significantly larger Nc peak amplitudes, Nc areas, Nc2 areas, Pb peak amplitudes and NSW areas to rare stimuli. While significant probability and experiential trends were observed in visual fixation measures across both study groups, there were no significant differences of visual attention between infants with DS or nDS. These data demonstrate the value of ERPs within the study of atypical cognitive development during infancy and support the concept of altered inhibitory processes in the brain of infants with DS.

[1]  Leslie G. Ungerleider,et al.  Face encoding and recognition in the human brain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. L. Fantz,et al.  Pattern vision in young infants , 1958 .

[3]  R. Bronson,et al.  A mouse model for Down syndrome exhibits learning and behaviour deficits , 1995, Nature Genetics.

[4]  J. A. Madsen,et al.  Life span changes in the averaged evoked responses of Down's syndrome and nonretarded persons. , 1978, American journal of mental deficiency.

[5]  P. Salapatek,et al.  Infant visual perception , 1983 .

[6]  G. Lubec,et al.  Auditory evoked potentials in young patients with Down syndrome. Event-related potentials (P3) and histaminergic system. , 1997, Brain research. Cognitive brain research.

[7]  E. Ryan,et al.  Relationships between Early Habituation and Later Cognitive Performance in Infancy. , 1977 .

[8]  M. Coussons‐Read,et al.  Behavioral assessment of the Ts65Dn mouse, a model for down syndrome: Altered behavior in the elevated plus maze and open field , 1996, Behavior genetics.

[9]  F. D. Horowitz,et al.  An Infant Control Procedure for Studying Infant Visual Fixations. , 1972 .

[10]  J. Polich,et al.  Normal variation of P300 in children: age, memory span, and head size. , 1990, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[11]  R. E. Dustman,et al.  Visual and somato-sensory evoked responses from mongoloid and normal children. , 1970, Electroencephalography and clinical neurophysiology.

[12]  Peter G. Caryl,et al.  Early event-related potentials correlate with in-spection time and intelligence , 1994 .

[13]  M. Oster-Granite.  The neurobiologic consequences of autosomal trisomy in mice and men , 1986, Brain Research Bulletin.

[14]  R. L. Fantz.  Visual Experience in Infants: Decreased Attention to Familiar Patterns Relative to Novel Ones , 1964, Science.

[15]  J. Colombo,et al.  The stability of visual habituation during the first year of life. , 1987, Child development.

[16]  J G Wishart,et al.  The development of learning difficulties in children with Down's syndrome. , 2008, Journal of intellectual disability research : JIDR.

[17]  M. Bornstein,et al.  Continuity in mental development from infancy. , 1986, Child development.

[18]  U Bellugi,et al.  Callosal morphology concurs with neurobehavioral and neuropathological findings in two neurodevelopmental disorders. , 1992, Archives of neurology.

[19]  J. Fagan,et al.  Chapter 4 – Early Visual Selectivity: As a Function of Pattern Variables, Previous Exposure, Age from Birth and Conception, and Expected Cognitive Deficit , 1975 .

[20]  B Horwitz,et al.  Cerebral metabolic pattern in young adult Down's syndrome subjects: altered intercorrelations between regional rates of glucose utilization. , 2008, Journal of mental deficiency research.

[21]  R. Karrer,et al.  Event-related potentials of 4-7-week-old infants in a visual recognition memory task. , 1995, Electroencephalography and clinical neurophysiology.

[22]  R. Mccall,et al.  A meta-analysis of infant habituation and recognition memory performance as predictors of later IQ. , 1993, Child development.

[23]  A. Brun,et al.  Prefrontal neocortical disturbances in mental retardation. , 2008, Journal of intellectual disability research : JIDR.

[24]  A. Barnet,et al.  EEG Evoked Responses to Repetitive Auditory Stimulation in Normal and Down's Syndrome Infants , 1971, Developmental medicine and child neurology.

[25]  Herbert G. Vaughan,et al.  Early identification of infants with developmental disabilities , 1988 .

[26]  M. Coles,et al.  Handbook of cognitive psychophysiology : central and autonomic nervous system approaches , 1991 .

[27]  R. L. Fantz,et al.  Visual preferences of Down's syndrome and normal infants. , 1973, Child development.

[28]  S. Sato,et al.  Relation of EEG alpha background to cognitive function, brain atrophy, and cerebral metabolism in Down's syndrome. Age-specific changes. , 1990, Archives of neurology.

[29]  A. Young,et al.  Handbook of Research on Face Processing , 1989 .

[30]  S. Porges,et al.  Recognition memory and cardiac vagal tone in 6-month-old infants , 1986 .

[31]  Edwina L. Rissland,et al.  Cognitive Science: An Introduction , 1987 .

[32]  R. Karrer,et al.  Differential effects of experience on the ERP and behavior of 6-month-old infants: trends during repeated stimulus presentations , 1994 .

[33]  I. Wallace,et al.  Visual recognition memory: a predictor of later cognitive functioning in preterms. , 1985, Child development.

[34]  R. Karrer,et al.  Event-related potentials and information processing in infants with and without Down syndrome. , 1995, American journal of mental retardation : AJMR.

[35]  D. Purpura,et al.  Dendritic Spine "Dysgenesis" and Mental Retardation , 1974, Science.

[36]  J. Yordanova,et al.  Alpha response system in children: changes with age. , 1997, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[37]  Charles A. Nelson,et al.  Event-related potential and looking-time analysis of infants' responses to familiar and novel events : implications for visual recognition memory , 1991 .

[38]  G. Galbraith,et al.  Visual evoked responses as a function of light intensity in Down's syndrome and nonretarded subjects. , 1975, Psychophysiology.

[39]  Sachio Takashima,et al.  Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative golgi study , 1981, Brain Research.

[40]  P. Salapatek,et al.  Evidence for visual memory in the averaged and single evoked potentials of human infants , 1981 .

[41]  G. Spiridigliozzi,et al.  Habituation and Cognitive Performance: Relationships Between Measures at Four Years of Age and Earlier Assessments , 1980 .

[42]  Recognition memory in Down's syndrome and normal infants. , 1974 .

[43]  R L FANTZ,et al.  The origin of form perception. , 1961, Scientific American.

[44]  E. Courchesne.  15 Cognitive Components of the Event-Related Brain Potential: Changes Associated with Development , 1983 .

[45]  Leslie B. Cohen,et al.  Infant perception: From sensation to cognition , 1975 .

[46]  A. H. Parmelee,et al.  Prediction of five-year Stanford-Binet scores in preterm infants. , 1983, Child development.

[47]  A. Young,et al.  ARE FACES SPECIAL , 1989 .

[48]  Lynn Nadel,et al.  The Psychobiology of Down syndrome , 1988 .

[49]  T Nettelbeck,et al.  Inspection Time: An Index for Intelligence? , 1982, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[50]  A. Slater,et al.  Prediction of childhood intelligence from habituation in early infancy , 1986 .

[51]  D W Shucard,et al.  Auditory event-related potentials in waking infants and adults: a developmental perspective. , 1987, Electroencephalography and clinical neurophysiology.

[52]  P Salapatek,et al.  Electrophysiological correlates of infant recognition memory. , 1986, Child development.

[53]  J. Richards,et al.  Sustained visual attention in young infants measured with an adapted version of the visual preference paradigm. , 1988, Child development.

[54]  L. Nadel,et al.  Down syndrome : living and learning in the community , 1995 .

[55]  Purpura Dp.  Dendritic differentiation in human cerebral cortex: normal and aberrant developmental patterns. , 1975 .

[56]  J. Osofsky.  Handbook of infant development , 1979 .

[57]  Mark H. Johnson,et al.  Biology and Cognitive Development: The Case of Face Recognition , 1993 .

[58]  R. Verleger,et al.  Late cognitive event-related potentials in adult down's syndrome , 1992, Biological Psychiatry.

[59]  S. Pueschel,et al.  Biomedical Concerns in Persons With Down Syndrome , 1992 .

[60]  L. Beckwith,et al.  Infant attention in relation to intellectual abilities in childhood. , 1986 .

[61]  M. Bornstein.  Habituation of attention as a measure of visual information processing in human infants: Summary , 1985 .

[62]  J. Feldman,et al.  Prediction of IQ and specific cognitive abilities at 11 years from infancy measures. , 1995 .

[63]  C. Rovee-Collier,et al.  Advances in infancy research , 1981 .

[64]  P. Salapatek,et al.  Young infants' event-related potentials (ERPs) to familiar and unfamiliar visual and auditory events in a recognition memory task. , 1981, Electroencephalography and clinical neurophysiology.

[65]  R. Karrer,et al.  Visual event-related potentials of infants during a modified oddball procedure. , 1987, Electroencephalography and clinical neurophysiology. Supplement.

[66]  A. Norcia,et al.  Event-related brain potentials to human faces in infants. , 1981, Child Development.

[67]  C. Nelson,et al.  Infants’ neuroelectric responses to missing stimuli: Can missing stimuli be novel stimuli? , 1990 .

[68]  C. Brunia,et al.  Psychophysiological brain research. , 1993 .

[69]  L. Becker,et al.  Dendrites, dementia and the down syndrome , 1989, Brain and Development.

[70]  N. Cairns,et al.  Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease , 1997, Neuroscience Letters.

[71]  R Galambos,et al.  Neuropsychological correlates of information-processing by children with Down syndrome. , 1985, American journal of mental deficiency.

[72]  G. Alexander,et al.  Gross motor milestones in preterm infants: correction for degree of prematurity. , 1990, The Journal of pediatrics.

[73]  G. Dawson,et al.  Human behavior and the developing brain , 1994 .

[74]  Joseph F. Fagan,et al.  Infant Recognition Memory and Later Intelligence. , 1981 .

[75]  C. Nelson,et al.  Developmental behavioral neuroscience , 1992 .

[76]  T. Petit,et al.  Abnormal electric membrane properties of Down's syndrome DRG neurons in cell culture. , 1981, Brain research.

[77]  M. Marín‐padilla.  Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study. , 1972, Brain research.

[78]  Cognitive Correlates of Infant Attention and Maternal Stimulation over the First Year of Life. , 1982 .

[79]  Norman A. Krasnegor,et al.  Measurement of Audition and Vision in the First Year of Postnatal Life: A Methodological Overview , 1985 .

[80]  E. Ryan,et al.  Relationships Between Assessments of Habituation and Cognitive Performance in the Early Years of Life , 1979 .

[81]  C. Nelson,et al.  Neural correlates of infants' visual responsiveness to facial expressions of emotion. , 1996, Developmental psychobiology.

[82]  Emanuel Donchin,et al.  12 Chronometric Analysis of Human Information Processing , 1983 .

[83]  A. Galaburda,et al.  Down's syndrome , 1984, Neurology.

[84]  C. Nelson,et al.  Neural correlates of attention and memory in the first year of life , 1992 .

[85]  C. Ehlers,et al.  Auditory event-related potentials in fetal alcohol syndrome and Down's syndrome children. , 1996, Alcoholism, clinical and experimental research.

[86]  Infant heart-rate responses to temporally predictable and unpredictable events , 1991 .

[87]  K. Wisniewski,et al.  ABNORMAL NEUROGENESIS AND SYNAPTOGENESIS IN DOWN SYNDROME BRAIN , 1994 .

[88]  Jeanne Brooks-Gunn,et al.  Visual Attention at Three Months as a Predictor of Cognitive Functioning at Two Years of Age. , 1981 .

[89]  A. Barnet,et al.  Click Evoked EEG Responses in Normal and Developmentally Retarded Infants , 1967, Nature.

[90]  John Colombo,et al.  individual Differences in infancy : Reliability, Stability, and Prediction , 1990 .

[91]  C. Epstein.  The Neurobiology of Down syndrome , 1986 .

[92]  P. Ohr,et al.  Conditioning and long-term memory in three-month-old infants with Down syndrome. , 1991, American journal of mental retardation : AJMR.

[93]  M. Marín‐Padilla,et al.  Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study , 1976, The Journal of comparative neurology.

[94]  H. G. Vaughan,et al.  Electrophysiologic assessment of auditory and visual function in the newborn. , 1985, Clinics in perinatology.

[95]  J. Richards,et al.  Development and stability in visual sustained attention in 14, 20, and 26 week old infants. , 1989, Psychophysiology.

[96]  H. Jasper,et al.  The ten-twenty electrode system of the International Federation. The International Federation of Clinical Neurophysiology. , 1999, Electroencephalography and clinical neurophysiology. Supplement.

[97]  Á. Pazos,et al.  Autoradiographic studies of neurotransmitter receptors in the brain of newborn infants with Down syndrome. , 2005, American journal of medical genetics. Supplement.