subset of chromosome ends , leading to propagation of a DNA damage response that induces senescence or cell death (

Matthew F. Pech, Alina Garbuzov, KazuteruHasegawa,Meena Sukhwani, Ruixuan J. Zhang, Bérénice A. Benayoun, Stephanie A. Brockman, Shengda Lin, Anne Brunet, Kyle E. Orwig, and Steven E. Artandi Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA; Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA; Department of Genetics, Stanford University, California 94305, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania 15213, USA; Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, USA; Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA

[1]  J. Boyle,et al.  Cancer-associated TERT promoter mutations abrogate telomerase silencing , 2015, eLife.

[2]  Param Priya Singh,et al.  A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate , 2015, Cell.

[3]  C. Bieberich,et al.  Functional and molecular features of the Id4+ germline stem cell population in mouse testes , 2014, Genes & development.

[4]  H. Enomoto,et al.  Mouse Spermatogenic Stem Cells Continually Interconvert between Equipotent Singly Isolated and Syncytial States , 2014, Cell stem cell.

[5]  D. Schadendorf,et al.  TERT Promoter Mutations in Familial and Sporadic Melanoma , 2013, Science.

[6]  Lynda Chin,et al.  Highly Recurrent TERT Promoter Mutations in Human Melanoma , 2013, Science.

[7]  A. Jacinto,et al.  Telomerase Is Required for Zebrafish Lifespan , 2013, PLoS genetics.

[8]  M. Saitou,et al.  Primordial germ cells in mice. , 2012, Cold Spring Harbor perspectives in biology.

[9]  A. Rajkovic,et al.  SOHLH1 and SOHLH2 coordinate spermatogonial differentiation. , 2012, Developmental biology.

[10]  R. Braun,et al.  Germline stem cells. , 2011, Cold Spring Harbor perspectives in biology.

[11]  D. Castrillon,et al.  Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis. , 2011, The Journal of clinical investigation.

[12]  K. Orwig,et al.  Spermatogonial stem cell regulation and spermatogenesis , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[13]  P. Lansdorp,et al.  Telomere length is inherited with resetting of the telomere set-point , 2010, Proceedings of the National Academy of Sciences.

[14]  R. Braun,et al.  Functional Hierarchy and Reversibility Within the Murine Spermatogenic Stem Cell Compartment , 2010, Science.

[15]  M. Oshimura,et al.  Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. , 2009, Cell stem cell.

[16]  Wilhelm Palm,et al.  How shelterin protects mammalian telomeres. , 2008, Annual review of genetics.

[17]  R. Lehmann,et al.  Germ Cells Are Forever , 2008, Cell.

[18]  Irving L. Weissman,et al.  Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age , 2007, Nature.

[19]  S. Toyokuni,et al.  Akt mediates self-renewal division of mouse spermatogonial stem cells , 2007, Development.

[20]  J. Hodgkin,et al.  trt-1 Is the Caenorhabditis elegans Catalytic Subunit of Telomerase , 2006, PLoS genetics.

[21]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  L. Riou,et al.  The telomerase activity of adult mouse testis resides in the spermatogonial alpha6-integrin-positive side population enriched in germinal stem cells. , 2005, Endocrinology.

[23]  S. Chanock,et al.  Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. , 2005, The New England journal of medicine.

[24]  Shawn Ahmed,et al.  Achieving immortality in the C. elegans germline , 2005, Ageing Research Reviews.

[25]  P. Pandolfi,et al.  Essential role of Plzf in maintenance of spermatogonial stem cells , 2004, Nature Genetics.

[26]  R. Braun,et al.  Plzf is required in adult male germ cells for stem cell self-renewal , 2004, Nature Genetics.

[27]  Yie Liu,et al.  Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[28]  N. Carter,et al.  A DNA damage checkpoint response in telomere-initiated senescence , 2003, Nature.

[29]  T. Lange,et al.  DNA Damage Foci at Dysfunctional Telomeres , 2003, Current Biology.

[30]  S. Toyokuni,et al.  Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells1 , 2003, Biology of reproduction.

[31]  H. Schöler,et al.  Identification and characterization of stem cells in prepubertal spermatogenesis in mice. , 2003, Developmental biology.

[32]  R. Brinster,et al.  Transplantation of testis germinal cells into mouse seminiferous tubules. , 2003, The International journal of developmental biology.

[33]  T. Volkert,et al.  E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. , 2002, Genes & development.

[34]  T. Vulliamy,et al.  The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita , 2001, Nature.

[35]  Margaret A. Strong,et al.  Telomere dysfunction triggers developmentally regulated germ cell apoptosis. , 2001, Molecular biology of the cell.

[36]  D. G. Rooij,et al.  All you wanted to know about spermatogonia but were afraid to ask. , 2000, Journal of andrology.

[37]  T. Shinohara,et al.  Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. D. de Rooij,et al.  Differential expression of c-kit in mouse undifferentiated and differentiating type A spermatogonia. , 1999, Endocrinology.

[39]  Lynda Chin,et al.  p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis , 1999, Cell.

[40]  R. DePinho,et al.  Essential role of mouse telomerase in highly proliferative organs , 1998, Nature.

[41]  B. Solomon,et al.  Loss of telomerase activity during male germ cell differentiation. , 1997, Endocrinology.

[42]  R. Weinberg,et al.  hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization , 1997, Cell.

[43]  C. Dani,et al.  Differentiation of embryonic stem cells into adipocytes in vitro. , 1997, Journal of cell science.

[44]  H. Schöler,et al.  Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. , 1996, Development.

[45]  R. Myers,et al.  Structure and variability of human chromosome ends , 1990, Molecular and cellular biology.

[46]  T. Kirkwood,et al.  The evolution of ageing and longevity , 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[47]  D. G. Rooij.  SPERMATOGONIAL STEM CELL RENEWAL IN THE MOUSE: I. NORMAL SITUATION , 1973 .

[48]  E. Oakberg.  Spermatogonial stem‐cell renewal in the mouse , 1971, The Anatomical record.

[49]  C. Huckins.  The spermatogonial stem cell population in adult rats. I. Their morphology, proliferation and maturation , 1971, The Anatomical record.