New Autonomous Motors of Metal-Organic Framework (MOF) Powered by Reorganization of Self-Assembled Peptides at interfaces

There have developed a variety of microsystems that harness energy and convert it to mechanical motion. Here we developed new autonomous biochemical motors by integrating metal-organic framework (MOF) and self-assembling peptides. MOF is applied as an energy-storing cell that assembles peptides inside nanoscale pores of the coordination framework. The robust assembling nature of peptides enables reconfiguring their assemblies at the water-MOF interface, which is converted to fuel energy. Re-organization of hydrophobic peptides could create the large surface tension gradient around the MOF and it efficiently powers the translation motion of MOF. As a comparison, the velocity of normalized by volume for the DPA-MOF particle is faster and the kinetic energy per the unit mass of fuel is more than twice as large as the one for previous gel motor systems. This demonstration opens the new application of MOF and reconfigurable molecular self-assembly and it may evolve into the smart autonomous motor that mimic bacteria to swim and harvest target chemicals by integrating recognition units.

[1]  Lisa Pakstis,et al.  Stimuli-responsive polypeptide vesicles by conformation-specific assembly , 2004, Nature materials.

[2]  E. Gazit,et al.  Controlled patterning of aligned self-assembled peptide nanotubes , 2006, Nature nanotechnology.

[3]  Yutaka Sumino,et al.  Self-running droplet: emergence of regular motion from nonequilibrium noise. , 2004, Physical review letters.

[4]  Colin Camerer.  : Past , Present , Future , 2003 .

[5]  K. Kinosita,et al.  Protrusive growth from giant liposomes driven by actin polymerization. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Derek N. Woolfson,et al.  Rational design and application of responsive α-helical peptide hydrogels , 2009, Nature materials.

[7]  Carl Henrik Görbitz,et al.  The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's beta-amyloid polypeptide. , 2006, Chemical communications.

[8]  John M. Beierle,et al.  Self-Assembling Sequence-Adaptive Peptide Nucleic Acids , 2009, Science.

[9]  Yoshihito Osada,et al.  Solvent-driven chemical motor , 1998 .

[10]  Rein V Ulijn,et al.  Enzyme-assisted self-assembly under thermodynamic control. , 2009, Nature nanotechnology.

[11]  T. Uemura,et al.  Highly photoconducting π-stacked polymer accommodated in coordination nanochannels. , 2012, Journal of the American Chemical Society.

[12]  Hideki Tanaka,et al.  Unveiling thermal transitions of polymers in subnanometre pores , 2010, Nature communications.

[13]  Gérard Férey,et al.  Hybrid porous solids: past, present, future. , 2008, Chemical Society reviews.

[14]  Takashi Ikegami,et al.  Fatty acid chemistry at the oil-water interface: self-propelled oil droplets. , 2007, Journal of the American Chemical Society.

[15]  Mircea Dincă,et al.  Hydrogen storage in metal-organic frameworks. , 2009, Chemical Society reviews.

[16]  W. Mori,et al.  Syntheses and Characterization of Microporous Coordination Polymers with Open Frameworks , 2002 .

[17]  Andreas Mershin,et al.  A classic assembly of nanobiomaterials , 2005, Nature Biotechnology.

[18]  Omar K Farha,et al.  Metal-organic framework materials as catalysts. , 2009, Chemical Society reviews.

[19]  Gérard Férey,et al.  Hybrid porous solids: past, present, future. , 2008, Chemical Society reviews.

[20]  Yoshihito Osada,et al.  Motion of Polymer Gels by Spreading Organic Fluid on Water , 1996 .

[21]  D. Frenkel,et al.  Enhancement of protein crystal nucleation by critical density fluctuations. , 1997, Science.

[22]  T. Uemura,et al.  Radical Polymerization of Vinyl Monomers in Porous Coordination Polymers: Nanochannel Size Effects on Reactivity, Molecular Weight, and Stereostructure , 2008 .

[23]  Chad A. Mirkin,et al.  Chemically tailorable colloidal particles from infinite coordination polymers , 2005, Nature.

[24]  Gary G. Borisy,et al.  Self-polarization and directional motility of cytoplasm , 1999, Current Biology.

[25]  M J Rosseinsky,et al.  Design, chirality, and flexibility in nanoporous molecule-based materials. , 2005, Accounts of chemical research.

[26]  T. Uemura,et al.  Fabrication of two-dimensional polymer arrays: template synthesis of polypyrrole between redox-active coordination nanoslits. , 2008, Angewandte Chemie.

[27]  S. Stupp,et al.  Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers , 2001, Science.

[28]  C. Marangoni.  Ueber die Ausbreitung der Tropfen einer Flüssigkeit auf der Oberfläche einer anderen , 1871 .

[29]  T. Uemura,et al.  Polymerization reactions in porous coordination polymers. , 2009, Chemical Society reviews.

[30]  Dos Santos FD,et al.  Free-running droplets. , 1995, Physical review letters.

[31]  Satoshi Nakata,et al.  Self-motion of a camphor disk on an aqueous phase depending on the alkyl chain length of sulfate surfactants. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[32]  Meital Reches,et al.  Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes , 2003, Science.

[33]  Alexander van Oudenaarden,et al.  Biomimetic Systems for Studying Actin-Based Motility , 2003, Current Biology.

[34]  Hong-Cai Zhou,et al.  Selective gas adsorption and separation in metal-organic frameworks. , 2009, Chemical Society reviews.

[35]  Anthony K. Cheetham,et al.  Hybrid Inorganic–Organic Solids: An Emerging Class of Nanoporous Catalysts , 2003 .

[36]  C. Görbitz.  Nanotube formation by hydrophobic dipeptides. , 2001, Chemistry.

[37]  T. Uemura,et al.  Functionalization of coordination nanochannels for controlling tacticity in radical vinyl polymerization. , 2010, Journal of the American Chemical Society.

[38]  Susumu Kitagawa,et al.  Functional porous coordination polymers. , 2004, Angewandte Chemie.

[39]  Kyriakos C. Stylianou,et al.  An Adaptable Peptide-Based Porous Material , 2010, Science.

[40]  Alexander van Oudenaarden,et al.  Probing polymerization forces by using actin-propelled lipid vesicles , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Gérard Férey,et al.  BioMOFs: metal-organic frameworks for biological and medical applications. , 2010, Angewandte Chemie.

[42]  Bartosz A Grzybowski,et al.  Maze solving by chemotactic droplets. , 2010, Journal of the American Chemical Society.

[43]  Gerard Tissot,et al.  A new Brewster angle microscope , 1998 .

[44]  Michael O'Keeffe,et al.  Reticular synthesis and the design of new materials , 2003, Nature.

[45]  A. Cavalier,et al.  Hierarchical architectures by synergy between dynamical template self-assembly and biomineralization. , 2007, Nature materials.