Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.

[1]  K. Dalziel,et al.  Crystalline 6-phosphogluconate dehydrogenase from sheep liver. , 1973, European journal of biochemistry.

[2]  J. Sommercorn,et al.  Regulation of hepatic phosphofructokinase by 6-phosphogluconate. , 1982, The Journal of biological chemistry.

[3]  D. Brocklehurst,et al.  The value of 6-phosphogluconate dehydrogenase (6-PGDH) activity as a marker of tumour cellularity and prognostic indicator in primary breast cancer. , 1986, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[4]  B. Dutrillaux,et al.  Relationships between UMPK and PGD activities and deletions of chromosome 1p in colorectal cancers. , 1991, Cancer genetics and cytogenetics.

[5]  T. Slater,et al.  Increased activity of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in purified cell suspensions and single cells from the uterine cervix in cervical intraepithelial neoplasia. , 1992, British Journal of Cancer.

[6]  S. Vermund,et al.  Alterations in erythrocyte glutathione metabolism associated with cervical dysplasias and carcinoma in situ. , 1993, Cancer investigation.

[7]  R J Read,et al.  Pushing the boundaries of molecular replacement with maximum likelihood. , 2003, Acta crystallographica. Section D, Biological crystallography.

[8]  S. Bonhoeffer,et al.  Cooperation and Competition in the Evolution of ATP-Producing Pathways , 2001, Science.

[9]  T. Roche,et al.  Organization of the Cores of the Mammalian Pyruvate Dehydrogenase Complex Formed by E2 and E2 Plus the E3-binding Protein and Their Capacities to Bind the E1 and E3 Components* , 2004, Journal of Biological Chemistry.

[10]  M. Freeling,et al.  Expression and distribution of cytosolic 6-phosphogluconate dehydrogenase isozymes in maize , 1992, Biochemical Genetics.

[11]  A. Pinchera,et al.  Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers. , 2008, Journal of proteome research.

[12]  Guido Kroemer,et al.  Tumor cell metabolism: cancer's Achilles' heel. , 2008, Cancer cell.

[13]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[14]  Jing Chen,et al.  Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth , 2009, Science Signaling.

[15]  K. Liu,et al.  Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment , 2009, Journal of neurochemistry.

[16]  Nick V Grishin,et al.  Lysine Acetylation Is a Highly Abundant and Evolutionarily Conserved Modification in Escherichia Coli*S , 2009, Molecular & Cellular Proteomics.

[17]  F. Khuri,et al.  Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. , 2011, Molecular cell.

[18]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[19]  F. Khuri,et al.  Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells , 2011, Molecular and Cellular Biology.

[20]  R. Shaw,et al.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.

[21]  Taro Hitosugi,et al.  Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. , 2012, Cancer cell.

[22]  F. Khuri,et al.  Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation , 2013, Nature Communications.

[23]  B. Garcia,et al.  Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. , 2014, Molecular cell.