Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine.

OBJECTIVE The authors performed a longitudinal study of the effects on thalamic volume of switching from typical to atypical antipsychotic medications. METHOD Magnetic resonance imaging scans were acquired from 10 subjects with chronic schizophrenia taking typical antipsychotics and 20 healthy volunteers. Subjects with schizophrenia were switched to olanzapine; both groups were rescanned. RESULTS At baseline, thalamic volumes in subjects with chronic schizophrenia were 5.8% greater than those of healthy volunteers. At follow-up, there was no significant difference between groups. Additional analysis revealed a significant positive correlation between baseline thalamic volume and dosage of typical antipsychotic medication. Higher dosages at baseline were correlated with larger reductions in volume after the switch to olanzapine. CONCLUSIONS Antipsychotic medication effects may be a factor in the wide range of thalamic volume differences reported between subjects with schizophrenia and healthy volunteers.

[1]  E. Cabanis,et al.  The Human Brain: Surface, Three-Dimensional Sectional Anatomy and Mri , 1991 .

[2]  J. Ehrhardt,et al.  Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. , 1990, Archives of general psychiatry.

[3]  J. Ehrhardt,et al.  Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. , 1995, The American journal of psychiatry.

[4]  W. Honer,et al.  Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophrenia. , 2004, The American journal of psychiatry.

[5]  J. Sweeney,et al.  Thalamic volumes in patients with first-episode schizophrenia. , 2001, The American journal of psychiatry.

[6]  R S Kahn,et al.  Partial volume decrease of the thalamus in relatives of patients with schizophrenia. , 1998, The American journal of psychiatry.

[7]  L. Friedman,et al.  Meta-analysis of thalamic size in schizophrenia , 2001, Biological Psychiatry.

[8]  D. Barnes,et al.  Quantitative Magnetic Resonance Imaging of the Brain : Applications for Tissue Segmentation and Multiple Sclerosis , 2014 .

[9]  N. Andreasen.  The Role of the Thalamus in Schizophrenia , 1997, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[10]  Lei Wang,et al.  Abnormalities of thalamic volume and shape in schizophrenia. , 2004, The American journal of psychiatry.

[11]  M J Harris,et al.  Quantitative magnetic resonance imaging of the brain in late-life schizophrenia. , 1995, The American journal of psychiatry.

[12]  R. Gur,et al.  Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. , 1998, The American journal of psychiatry.

[13]  David M. Smith,et al.  Cerebellar, prefrontal cortex, and thalamic volumes over two time points in adolescent-onset schizophrenia. , 2004, The American journal of psychiatry.

[14]  T Sharma,et al.  Magnetic resonance imaging of the thalamus in first-episode psychosis. , 2001, The American journal of psychiatry.