Age‐associated Changes in the Skin

Like all organ systems, the skin manifests an age-associated loss of functional capacity and increasing vulnerability to injury and certain disease states. Knowledge of the aging changes in normal skin assists the physician in diagnosis and management of certain dermatoses. Awareness of the important interactions between aging skin and the environment could lead to prevention of many disorders. The burden of skin disease for the elderly is often underestimated. It is psychosocial as well as medical, and although mortality is low, morbidity is high. A rational and caring approach by the general practitioners, family physicians, internists, and geriatricians responsible for this patient population should greatly improve the situation.

[1]  W. Hill,et al.  Regional Changes and Changes Caused by Age in the Normal Skin: A Histologic Study1 , 1940 .

[2]  J. G. Smith,et al.  SKIN LESIONS OF THE AGED AND THEIR ASSOCIATION WITH INTERNAL CHANGES. , 1963, JAMA.

[3]  G. Rajka.  Investigation of patients suffering from generalized pruritus, with special references to systemic diseases. , 1966, Acta dermato-venereologica.

[4]  R. Willkens,et al.  Impaired delayed hypersensitivity in an aging population. Association with antinuclear reactivity and rheumatoid factor. , 1968, JAMA.

[5]  W. C. Quevedo,et al.  Influence of age and UV on the populations of dopa-positive melanocytes in human skin. , 1969, The Journal of investigative dermatology.

[6]  M C Mihm,et al.  Early detection of primary cutaneous malignant melanoma. A color atlas. , 1973, The New England journal of medicine.

[7]  E. Emmett,et al.  Ultraviolet radiation as a cause of skin tumors. , 1973, CRC critical reviews in toxicology.

[8]  E. Freimer,et al.  AGEING, IMMUNE RESPONSE, AND MORTALITY , 1974 .

[9]  F. Urbach,et al.  Non‐melanoma skin cancer among caucasians in four areas of the United States , 1974, Cancer.

[10]  B. Armstrong,et al.  Letter: Breast cancer and spironolactone. , 1975, Lancet.

[11]  J. Elwood,et al.  Recent data on the epidemiology of malignant melanoma. , 1975, Seminars in oncology.

[12]  Elwood Jm,et al.  Recent data on the epidemiology of malignant melanoma. , 1975 .

[13]  M. Lebowitz,et al.  Immediate skin-test reactivity in a general population sample. , 1976, Annals of internal medicine.

[14]  R. Stern,et al.  Utilization of physician services for dermatologic complaints. The United States, 1974. , 1977, Archives of dermatology.

[15]  I. Mackay.  Changes in Human Lymphocyte Activity with Age1 , 1977 .

[16]  Marie-Louise T. Johnson.  Prevalence of dermatological disease among persons 1-74 years of age: United States , 1977 .

[17]  V. Cristofalo,et al.  Pharmacological Intervention in the Aging Process , 1978, Advances in Experimental Medicine and Biology.

[18]  B. Gilchrest.  Some gerontologic considerations in the practice of dermatology. , 1979, Archives of dermatology.

[19]  W. Montagna,et al.  Structural changes in aging human skin. , 1979, The Journal of investigative dermatology.

[20]  G. Martin.  Proliferative homeostasis and its age-related aberrations , 1979, Mechanisms of Ageing and Development.

[21]  A M Kligman,et al.  Perspectives and problems in cutaneous gerontology. , 1979, The Journal of investigative dermatology.

[22]  B. Gilchrest,et al.  Effects of aging and chronic sun exposure on melanocytes in human skin. , 1979, The Journal of investigative dermatology.

[23]  Edwin Silverberg,et al.  Cancer statistics, 1979 , 1979, CA: a cancer journal for clinicians.

[24]  J. Strauss,et al.  Age-related changes in sebaceous gland activity. , 1979, The Journal of investigative dermatology.

[25]  K. Bergmann,et al.  Handbook of the biology of aging , 1979 .

[26]  N. Orentreich,et al.  The effect of aging on the rate of linear nail growth. , 1979, The Journal of investigative dermatology.

[27]  J. Maize,et al.  Age‐related changes in melanocytic naevi , 1979, Clinical and experimental dermatology.

[28]  J. Folkman,et al.  Mast cell heparin stimulates migration of capillary endothelial cells in vitro , 1980, The Journal of experimental medicine.

[29]  R. Besdine.  Geriatric Medicine: An Overview , 1980, Annual Review of Gerontology and Geriatrics.

[30]  M C Mihm,et al.  Primary melanoma of the skin: recognition and management. , 1980, Journal of the American Academy of Dermatology.

[31]  B. Gilchrest.  Pruritus: pathogenesis, therapy, and significance in systemic disease states. , 1982, Archives of internal medicine.