Mechanical behavior of transparent nanofibrillar cellulose-chitosan nanocomposite films in dry and wet conditions.

Transparent, biocompatible and biodegradable chitosan (CS) nanocomposite films reinforced with nanofibrillar cellulose (NFC) were prepared by solution casting. The effects of NFC content on the mechanical properties in dry and wet conditions were investigated. The incorporation of NFC significantly enhanced the mechanical properties, especially in wet conditions. The ultimate tensile strength and Young׳s modulus of chitosan were improved by 12 times and 30 times, respectively, for the nanocomposite containing 32wt% of NFC in wet conditions. The mechanism of the remarkable reinforcements was studied by analyzing the swelling behavior of NFC-CS nanocomposites. The mechanical properties of wet NFC-CS nanocomposite films matched well with those of human skin, which demonstrate potential for uses as artificial skin and wound dressings.

[1]  Tianxi Liu,et al.  Biopolymer chitosan/montmorillonite nanocomposites: Preparation and characterization , 2005 .

[2]  E. Hellén,et al.  Nanofibrillar cellulose: In vitro study of cytotoxic and genotoxic properties , 2010 .

[3]  A Diffusion Model for Spin-Spin Relaxation of Compartmentalized Water in Wood , 1993 .

[4]  M. Rinaudo,et al.  Chitin and chitosan: Properties and applications , 2006 .

[5]  Tejraj M Aminabhavi,et al.  Recent advances on chitosan-based micro- and nanoparticles in drug delivery. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[6]  H Alexander,et al.  Accounting for natural tension in the mechanical testing of human skin. , 1977, The Journal of investigative dermatology.

[7]  Jose M. Lagaron,et al.  High Water Barrier Nanobiocomposites of Methyl Cellulose and Chitosan for Film and Coating Applications , 2009 .

[8]  J. Militký,et al.  Reinforcement of wet milled jute nano/micro particles in polyvinyl alcohol films , 2013, Fibers and Polymers.

[9]  Stuart J. Rowan,et al.  Bioinspired Mechanically Adaptive Polymer Nanocomposites with Water-Activated Shape-Memory Effect , 2011 .

[10]  A. Gandini,et al.  Transparent chitosan films reinforced with a high content of nanofibrillated cellulose , 2010 .

[11]  Hiroyuki Yano,et al.  Novel high-strength biocomposites based on microfibrillated cellulose having nano-order-unit web-like network structure , 2005 .

[12]  K. Oksman,et al.  Effect of pretreatment of bagasse fibers on the properties of chitosan/microfibrillated cellulose nanocomposites , 2011 .

[13]  Marielle Henriksson,et al.  Cellulose nanopaper structures of high toughness. , 2008, Biomacromolecules.

[14]  W. Batchelor,et al.  Water interaction in paper cellulose fibres as investigated by NMR pulsed field gradient. , 2012, Carbohydrate polymers.

[15]  F. Horkay,et al.  Studies on the swelling and shrinking kinetics of chemically cross-linked disk-shaped poly(vinyl acetate) gels , 1993 .

[16]  B. Krajewska.  Application of chitin- and chitosan-based materials for enzyme immobilizations: a review , 2004 .

[17]  Yoshiharu Nishiyama,et al.  Structure and properties of the cellulose microfibril , 2009, Journal of Wood Science.

[18]  O. Ikkala,et al.  Enzymatic hydrolysis combined with mechanical shearing and high-pressure homogenization for nanoscale cellulose fibrils and strong gels. , 2007, Biomacromolecules.

[19]  K. R. Sandberg,et al.  Microfibrillated cellulose, a new cellulose product: properties, uses, and commercial potential , 1983 .

[20]  T. Budtova,et al.  Solvent release from highly swollen gels under compression , 2003 .

[21]  Masaru Matsuo,et al.  Effect of orientation distribution and crystallinity on the measurement by x-ray diffraction of the crystal lattice moduli of cellulose I and II , 1990 .

[22]  K. Katti,et al.  Mechanical response and multilevel structure of biomimetic hydroxyapatite/polygalacturonic/chitosan nanocomposites , 2008 .

[23]  Cristina M. R. Rocha,et al.  Physico-chemical characterization of chitosan-based edible films incorporating bioactive compounds of different molecular weight , 2011 .

[24]  K. Rhee,et al.  Application of cryomilling to enhance material properties of carbon nanotube reinforced chitosan nanocomposites , 2013 .

[25]  David Plackett,et al.  Microfibrillated cellulose and new nanocomposite materials: a review , 2010 .

[26]  J. Hamilton,et al.  Microfibrillated cellulose: morphology and accessibility , 1983 .

[27]  John Crank,et al.  The Mathematics Of Diffusion , 1956 .

[28]  J. Manschot,et al.  The measurement and modelling of the mechanical properties of human skin in vivo--II. The model. , 1986, Journal of biomechanics.

[29]  Lin Li,et al.  Green fabrication of chitosan films reinforced with parallel aligned graphene oxide , 2011 .

[30]  R. Muzzarelli.  Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone , 2009 .

[31]  L. Berglund,et al.  Making flexible magnetic aerogels and stiff magnetic nanopaper using cellulose nanofibrils as templates. , 2010, Nature nanotechnology.

[32]  K. Oksman,et al.  Chitosan/rice straw nanofibers nanocomposites: Preparation, mechanical, and dynamic thermomechanical properties , 2012 .

[33]  Lina Zhang,et al.  Structure and properties of the nanocomposite films of chitosan reinforced with cellulose whiskers , 2009 .

[34]  Masaya Nogi,et al.  Optically Transparent Nanofiber Paper , 2009 .

[35]  P. Badot,et al.  Application of chitosan, a natural aminopolysaccharide, for dye removal from aqueous solutions by adsorption processes using batch studies: A review of recent literature , 2008 .

[36]  Hitoshi Sashiwa,et al.  Chemically modified chitin and chitosan as biomaterials , 2004 .

[37]  Kentaro Abe,et al.  Excellent thermal conductivity of transparent cellulose nanofiber/epoxy resin nanocomposites. , 2007, Biomacromolecules.

[38]  S. Şenel,et al.  Potential applications of chitosan in veterinary medicine. , 2004, Advanced drug delivery reviews.

[39]  Michael D. Gilchrist,et al.  Mechanical Properties of Excised Human Skin , 2010 .

[40]  Charlotte K. Williams,et al.  Polymers from Renewable Resources: A Perspective for a Special Issue of Polymer Reviews , 2008 .

[41]  Hiroyuki Yano,et al.  The effect of morphological changes from pulp fiber towards nano-scale fibrillated cellulose on the mechanical properties of high-strength plant fiber based composites , 2004 .

[42]  Y. Dahman,et al.  Optically transparent nanocomposites reinforced with modified biocellulose nanofibers , 2012 .

[43]  R. Pedrosa,et al.  Effect of crosslinking agents on chitosan microspheres in controlled release of diclofenac sodium , 2005 .

[44]  N. Marcovich,et al.  Water vapor absorption and permeability of films based on chitosan and sodium caseinate , 2009 .

[45]  M. N. R. Kumar.  A review of chitin and chitosan applications , 2000 .

[46]  S. Pang,et al.  Long-term moisture absorption and thickness swelling behaviour of recycled thermoplastics reinforced with Pinus radiata sawdust , 2008 .

[47]  Federica Chiellini,et al.  Chitosan—A versatile semi-synthetic polymer in biomedical applications , 2011 .

[48]  K. Asaoka,et al.  Diffusion coefficient of water through dental composite resin. , 2003, Biomaterials.

[49]  Qiuju Wu,et al.  A high strength nanocomposite based on microcrystalline cellulose and polyurethane. , 2007, Biomacromolecules.

[50]  In-Yong Kim,et al.  Chitosan and its derivatives for tissue engineering applications. , 2008, Biotechnology advances.

[51]  T. Bechtold,et al.  All-cellulose composites from woven fabrics , 2013 .

[52]  C. Iversen,et al.  Characterization of association phenomena in aqueous systems of chitosan of different hydrophobicity , 1999 .

[53]  K. Yao,et al.  Modulation of nano-hydroxyapatite size via formation on chitosan-gelatin network film in situ. , 2007, Biomaterials.

[54]  Q. Yuan,et al.  Preparation and characterization of metal-chitosan nanocomposites. , 2004, Colloids and surfaces. B, Biointerfaces.

[55]  C. Pillai,et al.  Chitin and chitosan polymers: Chemistry, solubility and fiber formation , 2009 .

[56]  F. Marken,et al.  Nanofibrillar Cellulose-Chitosan Composite Film Electrodes: Competitive Binding of Triclosan, Fe(CN)63−/4−, and SDS Surfactant , 2008 .

[57]  Shantikumar V. Nair,et al.  Biomedical applications of chitin and chitosan based nanomaterials—A short review , 2010 .

[58]  M. Ree,et al.  WATER DIFFUSION AND SORPTION IN FILMS OF HIGH-PERFORMANCE POLY(4,4'-OXYDIPHENYLENE PYROMELLITIMIDE) - EFFECTS OF HUMIDITY, IMIDIZATION HISTORY AND FILM THICKNESS , 1995 .

[59]  F. Shahidi,et al.  Food applications of chitin and chitosans , 1999 .

[60]  E. Espuche,et al.  Transport properties of chitosan membranes: Influence of crosslinking , 2000 .

[61]  A. Gandini,et al.  Novel transparent nanocomposite films based on chitosan and bacterial cellulose , 2009 .

[62]  J. Desbrières,et al.  Influence of acetic acid concentration on the solubilization of chitosan , 1999 .

[63]  Eugene Khor,et al.  Implantable applications of chitin and chitosan. , 2003, Biomaterials.

[64]  J. Manschot,et al.  The measurement and modelling of the mechanical properties of human skin in vivo--I. The measurement. , 1986, Journal of biomechanics.

[65]  Ichiro Sakurada,et al.  Experimental determination of the elastic modulus of crystalline regions in oriented polymers , 1962 .

[66]  M. Braden,et al.  Water absorption characteristics of dental composites incorporating hydroxyapatite filler. , 2002, Biomaterials.