Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods

One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and protective factors influencing substance use and its consequences, examine the impact of substance use on neurocognitive, health and psychosocial outcomes, and to understand the relationship between substance use and psychopathology. This article provides an overview of the ABCD Study Substance Use Workgroup, provides the goals for the workgroup, rationale for the substance use battery, and includes details on the substance use module methods and measurement tools used during baseline, 6-month and 1-year follow-up assessment time-points. Prospective, longitudinal assessment of these substance use domains over a period of ten years in a nationwide sample of youth presents an unprecedented opportunity to further understand the timing and interactive relationships between substance use and neurocognitive, health, and psychopathology outcomes in youth living in the United States.

[1]  Murat Yücel,et al.  Structural and Functional Imaging Studies in Chronic Cannabis Users: A Systematic Review of Adolescent and Adult Findings , 2013, European Psychiatry.

[2]  W. van den Brink,et al.  Impulsivity and attentional bias as predictors of modafinil treatment outcome for retention and drug use in crack-cocaine dependent patients: Results of a randomised controlled trial , 2016, Journal of psychopharmacology.

[3]  John H. Krystal,et al.  Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers , 2005, Biological Psychiatry.

[4]  M. Cohen-Zion,et al.  Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. , 2007, Neurotoxicology and teratology.

[5]  F. Gibbons,et al.  E-cigarette use and willingness to smoke: a sample of adolescent non-smokers , 2015, Tobacco Control.

[6]  B. Cohen,et al.  Dose-Related Behavioral, Subjective, Endocrine, and Psychophysiological Effects of the κ Opioid Agonist Salvinorin A in Humans , 2012, Biological Psychiatry.

[7]  Kate B. Carey,et al.  Validating a Five-Factor Marijuana Motives Measure: Relations with Use, Problems, and Alcohol Motives. , 1998 .

[8]  Erno J. Hermans,et al.  Effects of exogenous testosterone on the ventral striatal BOLD response during reward anticipation in healthy women , 2010, NeuroImage.

[9]  E. Soule,et al.  Effects of Electronic Cigarette Liquid Nicotine Concentration on Plasma Nicotine and Puff Topography in Tobacco Cigarette Smokers: A Preliminary Report. , 2016, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[10]  C. Vorhees,et al.  Glucose and corticosterone changes in developing and adult rats following exposure to (+/-)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine. , 2010, Neurotoxicology and teratology.

[11]  J. Temple,et al.  Caffeine use in children: What we know, what we have left to learn, and why we should worry , 2009, Neuroscience & Biobehavioral Reviews.

[12]  O. Mason,et al.  Neurocognitive Function and Schizophrenia-Proneness in Individuals Dependent on Ketamine, on High Potency Cannabis (‘Skunk’) or on Cocaine , 2012, Pharmacopsychiatry.

[13]  D. Hedeker,et al.  Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use. , 2016, Addiction.

[14]  S. Tapert,et al.  Depressive symptoms in adolescents: associations with white matter volume and marijuana use. , 2007, Journal of child psychology and psychiatry, and allied disciplines.

[15]  R. Todd Constable,et al.  Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers , 2007, Psychopharmacology.

[16]  M. Yücel,et al.  Verbal memory, learning, and executive functioning among adolescent inhalant and cannabis users. , 2011, Journal of studies on alcohol and drugs.

[17]  Brian A. King,et al.  E-cigarette curiosity among U.S. middle and high school students: Findings from the 2014 national youth tobacco survey. , 2016, Preventive medicine.

[18]  S. Siegel,et al.  Delayed emergence of behavioral and electrophysiological effects following juvenile ketamine exposure in mice , 2015, Translational Psychiatry.

[19]  Lin Sun,et al.  Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys , 2014, Addiction biology.

[20]  J. Riba,et al.  New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca. , 2015, Current topics in behavioral neurosciences.

[21]  I. Franken,et al.  Error-Related Brain Activity as a Biomarker for Cocaine Relapse , 2014, Neuropsychopharmacology.

[22]  E. Stice,et al.  The relation between adolescent alcohol use and peer alcohol use: a longitudinal random coefficients model. , 1997, Journal of consulting and clinical psychology.

[23]  D. Mckenna,et al.  Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca. , 1984, Journal of ethnopharmacology.

[24]  A. Toga,et al.  In vivo evidence for post-adolescent brain maturation in frontal and striatal regions , 1999, Nature Neuroscience.

[25]  K. Jackson,et al.  Hangover frequency and risk for alcohol use disorders: evidence from a longitudinal high-risk study. , 2005, Journal of abnormal psychology.

[26]  L. Kozlowski,et al.  The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. , 1991, British journal of addiction.

[27]  Michael W. Arthur,et al.  Measuring risk and protection in communities using the Communities That Care Youth Survey. , 2007, Evaluation and program planning.

[28]  D. Compton,et al.  5-Methoxy-N,N-di(iso)propyltryptamine hydrochloride (Foxy)-induced cognitive deficits in rat after exposure in adolescence , 2011, Physiology & Behavior.

[29]  M. Yücel,et al.  Executive control among adolescent inhalant and cannabis users. , 2011, Drug and alcohol review.

[30]  E. Rice,et al.  Association between prescription drug misuse and injection among runaway and homeless youth. , 2014, Drug and alcohol dependence.

[31]  J. Schulenberg,et al.  Adolescent context of exposure to prescription opioids and substance use disorder symptoms at age 35: a national longitudinal study , 2016, Pain.

[32]  F. Carvalho,et al.  The hallucinogenic world of tryptamines: an updated review , 2015, Archives of Toxicology.

[33]  J. J. Couey,et al.  Nicotinic actions on neuronal networks for cognition: general principles and long-term consequences. , 2009, Biochemical pharmacology.

[34]  Dustin C. Lee,et al.  Smoking, vaping, eating: Is legalization impacting the way people use cannabis? , 2016, The International journal on drug policy.

[35]  B. Miller,et al.  The Dabbing Dilemma: A Call for Research on Butane Hash Oil and Other Alternate Forms of Cannabis Use , 2015, Substance abuse.

[36]  Megan E. Patrick,et al.  Monitoring the Future national survey results on drug use, 1975-2017: Overview, key findings on adolescent drug use , 2016 .

[37]  Nora D Volkow,et al.  Adverse health effects of marijuana use. , 2014, The New England journal of medicine.

[38]  T. Lundqvist,et al.  Imaging cognitive deficits in drug abuse. , 2010, Current topics in behavioral neurosciences.

[39]  Sarah E. Adkison,et al.  Psychometric Characteristics of the Brief Wisconsin Inventory of Smoking Dependence Motives Among a Nonclinical Sample of Smokers. , 2016, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[40]  M. Nitsche,et al.  Cognitive related electrophysiological changes induced by non-invasive cortical electrical stimulation in crack-cocaine addiction. , 2014, The international journal of neuropsychopharmacology.

[41]  N. Ramsey,et al.  Neurotoxic effects of ecstasy on the thalamus , 2008, British Journal of Psychiatry.

[42]  I. Grant,et al.  Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-analysis , 2007, Neuropsychology Review.

[43]  T T Yang,et al.  White matter integrity in adolescents with histories of marijuana use and binge drinking. , 2009, Neurotoxicology and teratology.

[44]  Sheri J. Hartman,et al.  Curiosity predicts smoking experimentation independent of susceptibility in a US national sample. , 2014, Addictive behaviors.

[45]  S. Tapert,et al.  Initiating moderate to heavy alcohol use predicts changes in neuropsychological functioning for adolescent girls and boys. , 2009, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[46]  H. White,et al.  An investigation of factors related to intoxicated driving behaviors among youth. , 1989, Journal of studies on alcohol.

[47]  Jennifer L. Pearson,et al.  Susceptibility to tobacco product use among youth in wave 1 of the population Assessment of tobacco and health (PATH) study. , 2017, Preventive medicine.

[48]  F. Filbey,et al.  Combined effects of marijuana and nicotine on memory performance and hippocampal volume , 2015, Behavioural Brain Research.

[49]  Michael C Neale,et al.  The dynamic role of genetics on cortical patterning during childhood and adolescence , 2014, Proceedings of the National Academy of Sciences.

[50]  W. Iacono,et al.  Origins and consequences of age at first drink. I. Associations with substance-use disorders, disinhibitory behavior and psychopathology, and P3 amplitude. , 2001, Alcoholism, clinical and experimental research.

[51]  J. Currie,et al.  Effects of Methylphenidate on Cognitive Functions in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Evidence from a Systematic Review and a Meta-Analysis , 2014, Biological Psychiatry.

[52]  W. Slutske,et al.  Development and initial validation of the Hangover Symptoms Scale: prevalence and correlates of Hangover Symptoms in college students. , 2003, Alcoholism, clinical and experimental research.

[53]  R. Stephens,et al.  Cognitive and psychomotor performance during alcohol hangover. , 2010, Current drug abuse reviews.

[54]  Shenmin Zhang,et al.  Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: duration of use and gender difference. , 2014, Drug and alcohol dependence.

[55]  Jane Metrik,et al.  Test-retest reliability of alcohol measures: is there a difference between internet-based assessment and traditional methods? , 2002, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[56]  R. Sircar,et al.  γ‐Hydroxybutyric Acid–Induced Cognitive Deficits in the Female Adolescent Rat , 2008, Annals of the New York Academy of Sciences.

[57]  T. Jernigan,et al.  Development of cortical and subcortical brain structures in childhood and adolescence: a structural MRI study , 2002, Developmental medicine and child neurology.

[58]  D. Pfaff,et al.  Exercise reinforcement, stress, and β-endorphins: an initial examination of exercise in anabolic-androgenic steroid dependence. , 2014, Drug and alcohol dependence.

[59]  Stephanie T. Lanza,et al.  New methods shed light on age of onset as a risk factor for nicotine dependence. , 2015, Addictive behaviors.

[60]  Megan E. Piper,et al.  Development of the Brief Wisconsin Inventory of Smoking Dependence Motives. , 2010, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[61]  Kevin Conway,et al.  Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products , 2017, Neuroscience & Biobehavioral Reviews.

[62]  S. Tapert,et al.  Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence. , 2010, Addictive behaviors.

[63]  Thomas V. Rousselle,et al.  Enhancing effect of menthol on nicotine self-administration in rats , 2016, Psychopharmacology.

[64]  K. Kamińska,et al.  Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats , 2016, Neurotoxicity Research.

[65]  R. Wood,et al.  Anabolic–androgenic steroids impair set-shifting and reversal learning in male rats , 2015, European Neuropsychopharmacology.

[66]  P. Shear,et al.  Memory functioning in polysubstance dependent women. , 2006, Drug and alcohol dependence.

[67]  K. Carey,et al.  An affective and cognitive model of marijuana and alcohol problems. , 2006, Addictive behaviors.

[68]  S. Tapert,et al.  Effects of cannabis on the adolescent brain. , 2014, Current pharmaceutical design.

[69]  G. Matt,et al.  Learning and Memory in Adolescent Moderate, Binge, and Extreme-Binge Drinkers. , 2016, Alcoholism, clinical and experimental research.

[70]  C. Pomerleau,et al.  Early experiences with tobacco among women smokers, ex-smokers, and never-smokers. , 1998, Addiction.

[71]  M. Packard,et al.  Neural Correlates of Reward-Based Spatial Learning in Persons with Cocaine Dependence , 2014, Neuropsychopharmacology.

[72]  J. Verster The alcohol hangover--a puzzling phenomenon. , 2008, Alcohol and alcoholism.

[73]  K. Carey,et al.  Risk and vulnerability for marijuana use problems: The role of affect dysregulation , 2002 .

[74]  R. Wiers,et al.  Cocaine use severity and cerebellar gray matter are associated with reversal learning deficits in cocaine‐dependent individuals , 2015, Addiction biology.

[75]  N. Ramsey,et al.  Assessment of Cognitive Brain Function in Ecstasy Users and Contributions of Other Drugs of Abuse: Results from an fMRI Study , 2008, Neuropsychopharmacology.

[76]  C. Vorhees,et al.  Electroencephalographic and convulsive effects of binge doses of (+)-methamphetamine, 5-methoxydiisopropyltryptamine, and (±)-3,4-methylenedioxymethamphetamine in rats. , 2012, The open neuropsychopharmacology journal.

[77]  W. Kraemer,et al.  Cognitive and motor function after administration of hydrocodone bitartrate plus ibuprofen, ibuprofen alone, or placebo in healthy subjects with exercise-induced muscle damage: a randomized, repeated-dose, placebo-controlled study , 2003, Psychopharmacology.

[78]  E. Pennings,et al.  Effects of concurrent use of alcohol and cocaine. , 2002, Addiction.

[79]  Torsten Rohlfing,et al.  Adolescent Development of Cortical and White Matter Structure in the NCANDA Sample: Role of Sex, Ethnicity, Puberty, and Alcohol Drinking. , 2016, Cerebral cortex.

[80]  N. Ahluwalia,et al.  Caffeine intake from food and beverage sources and trends among children and adolescents in the United States: review of national quantitative studies from 1999 to 2011. , 2015, Advances in nutrition.

[81]  T. Albertson,et al.  The Changing Drug Culture: Use and Misuse of Cognition-Enhancing Drugs. , 2016, FP essentials.

[82]  E. Soule,et al.  Electronic cigarettes: what are they and what do they do? , 2017, Annals of the New York Academy of Sciences.

[83]  E. Gilpin,et al.  Validation of susceptibility as a predictor of which adolescents take up smoking in the United States. , 1996, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[84]  E. Forbes,et al.  Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt , 2015, Psychopharmacology.

[85]  K. Higgins,et al.  Adolescent ecstasy use and depression: cause and effect, or two outcomes of home environment? , 2014, European journal of public health.

[86]  R. Wood,et al.  Anabolic-androgenic steroids decrease dendritic spine density in the nucleus accumbens of male rats , 2016, Neuroscience.

[87]  K. Carey,et al.  Alcohol use and cerebral white matter compromise in adolescence. , 2013, Addictive behaviors.

[88]  M. Goldman,et al.  The Alcohol Expectancy Questionnaire: an instrument for the assessment of adolescent and adult alcohol expectancies. , 1987, Journal of studies on alcohol.

[89]  Liang-Jen Wang,et al.  Neurocognitive Profiles of Methamphetamine Users: Comparison of Those With or Without Concomitant Ketamine Use , 2015, Substance use & misuse.

[90]  K. Lisdahl,et al.  Increased Marijuana Use and Gender Predict Poorer Cognitive Functioning in Adolescents and Emerging Adults , 2012, Journal of the International Neuropsychological Society.

[91]  E. Sellers,et al.  Reduced cognitive and psychomotor impairment with extended-release oxymorphone versus controlled-release oxycodone. , 2010, Pain physician.

[92]  K. Lisdahl,et al.  Considering Cannabis: The Effects of Regular Cannabis Use on Neurocognition in Adolescents and Young Adults , 2014, Current Addiction Reports.

[93]  Megan E. Patrick,et al.  Novel psychoactive substance use by US adolescents: Characteristics associated with use of synthetic cannabinoids and synthetic cathinones. , 2016, Drug and alcohol review.

[94]  Oliver Speck,et al.  Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study , 2000, Psychiatry Research: Neuroimaging.

[95]  P. Caldwell Drinking Levels, Related Problems and Readiness to Change in a College Sample , 2002 .

[96]  T. Stalder,et al.  Reduced memory skills and increased hair cortisol levels in recent Ecstasy/MDMA users: significant but independent neurocognitive and neurohormonal deficits , 2015, Human psychopharmacology.

[97]  Brian A. King,et al.  Intentions to smoke cigarettes among never-smoking US middle and high school electronic cigarette users: National Youth Tobacco Survey, 2011-2013. , 2015, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[98]  A. Budney,et al.  Caffeine addiction? Caffeine for youth? Time to act! , 2014, Addiction.

[99]  K. Lisdahl,et al.  Dare to Delay? The Impacts of Adolescent Alcohol and Marijuana Use Onset on Cognition, Brain Structure, and Function , 2013, Front. Psychiatry.

[100]  M. Yücel,et al.  A Signal Detection Analysis of Executive Control Performance Among Adolescent Inhalant and Cannabis Users , 2014, Substance use & misuse.

[101]  Susan F. Tapert,et al.  Altered white matter microstructure in adolescent substance users , 2009, Psychiatry Research: Neuroimaging.

[102]  Mitch Earleywine,et al.  A new method of cannabis ingestion: the dangers of dabs? , 2014, Addictive behaviors.

[103]  P. Fagan,et al.  Little Cigars and Cigarillos Use Among Young Adult Cigarette Smokers in the United States: Understanding Risk of Concomitant Use Subtypes. , 2016, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[104]  B. Everitt,et al.  Profiles of Cognitive Dysfunction in Chronic Amphetamine and Heroin Abusers , 2000, Neuropsychopharmacology.

[105]  L. Johnston,et al.  Monitoring the Future national survey results on drug use, 1975-2019: Volume I, Secondary school students , 2017 .

[106]  Thomas F. Nugent,et al.  Dynamic mapping of human cortical development during childhood through early adulthood. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[107]  M. Pérez-García,et al.  Prevalence of executive dysfunction in cocaine, heroin and alcohol users enrolled in therapeutic communities. , 2010, European journal of pharmacology.

[108]  J. Wiley,et al.  Tasty THC: Promises and Challenges of Cannabis Edibles. , 2016, Methods report.

[109]  T. Wienker,et al.  Neurocognitive impairments in non‐deprived smokers—results from a population‐based multi‐center study on smoking‐related behavior , 2013, Addiction biology.

[110]  Patrick M. O'Malley,et al.  Monitoring the Future: National Survey Results on Drug Use, 1975-2006. Volume II: College Students & Adults Ages 19-25. NIH Publication No. 07-6206. , 2007 .

[111]  K. Jackson,et al.  The prospective association between sipping alcohol by the sixth grade and later substance use. , 2015, Journal of studies on alcohol and drugs.

[112]  Torsten Rohlfing,et al.  The National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA): A Multisite Study of Adolescent Development and Substance Use. , 2015, Journal of studies on alcohol and drugs.

[113]  P. Monti,et al.  Validation of the Marijuana Effect Expectancy Questionnaire-Brief , 2008, Journal of child & adolescent substance abuse.

[114]  A. Breland,et al.  Science and Electronic Cigarettes: Current Data, Future Needs , 2014, Journal of addiction medicine.

[115]  R. Tyndale,et al.  Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice , 2015, PloS one.

[116]  M. Clark,et al.  Access to substance use treatment among young adults who use prescription opioids non-medically , 2016, Substance Abuse Treatment, Prevention, and Policy.

[117]  T. Heeren,et al.  Age at drinking onset and alcohol dependence: age at onset, duration, and severity. , 2006, Archives of pediatrics & adolescent medicine.

[118]  Pankaj Sharma,et al.  Foxy, a designer tryptamine hallucinogen. , 2003, Journal of analytical toxicology.

[119]  J. Verster,et al.  The pathology of alcohol hangover. , 2010, Current drug abuse reviews.

[120]  Dan J Stein,et al.  Methamphetamine and cannabis abuse in adolescence: a quasi-experimental study on specific and long-term neurocognitive effects , 2015, BMJ Open.

[121]  L. Johnston Illicit Drug Use, Smoking and Drinking by America's High School Students, College Students, and Young Adults: 1975-1987 , 1993 .

[122]  J. Homberg,et al.  White matter alterations in cocaine users are negatively related to the number of additionally (ab)used substances , 2017, Addiction biology.

[123]  C. Kaplan,et al.  Understanding dabs: contamination concerns of cannabis concentrates and cannabinoid transfer during the act of dabbing. , 2015, The Journal of toxicological sciences.

[124]  Joy L. Johnson,et al.  Adolescents' self-defined tobacco use status, marijuana use, and tobacco dependence. , 2008, Addictive behaviors.

[125]  Connie Lim,et al.  Youth risk behavior surveillance--United States, 2005. , 2006, The Journal of school health.

[126]  J. Giedd,et al.  Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging , 2006, Neuroscience & Biobehavioral Reviews.

[127]  Joseph Pratt,et al.  Data compatibility in the addiction sciences: an examination of measure commonality. , 2014, Drug and alcohol dependence.

[128]  T. Przybeck,et al.  Age of onset of drug use as a factor in drug and other disorders. , 1985, NIDA research monograph.

[129]  B. Grant,et al.  Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. , 2008, Alcoholism, clinical and experimental research.

[130]  Deborah A Yurgelun-Todd,et al.  Cerebellar Gray Matter Volume Correlates with Duration of Cocaine Use in Cocaine-Dependent Subjects , 2007, Neuropsychopharmacology.

[131]  L. Ray,et al.  Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations. , 2011, Addictive behaviors.

[132]  D R Offord,et al.  Age at first alcohol use: a risk factor for the development of alcohol disorders. , 2000, The American journal of psychiatry.

[133]  T. E. Dielman,et al.  Structural Equation Model Tests of Patterns of Family Interaction, Peer Alcohol Use, and Intrapersonal Predictors of Adolescent Alcohol Use and Misuse , 1993, Journal of drug education.

[134]  S. Tapert,et al.  Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. , 2008, Alcoholism, clinical and experimental research.

[135]  Q. Rahman,et al.  Sex differences in neurocognitive functioning among abstinent recreational cocaine users , 2005, Psychopharmacology.

[136]  J. Baird,et al.  Energy Drink and Other Substance Use Among Adolescent and Young Adult Emergency Department Patients , 2013, Pediatric emergency care.

[137]  J. Montaner,et al.  Non-Injection Drug Use Patterns and History of Injection among Street Youth , 2010, European Addiction Research.

[138]  D. Hasin,et al.  Neuropsychological Assessment Battery-Screening Module (S-NAB): Performance in treatment-seeking cocaine users , 2014, The American journal of drug and alcohol abuse.

[139]  K. Robertson,et al.  Independent effects of HIV infection and cocaine dependence on neurocognitive impairment in a community sample living in the southern United States. , 2015, Drug and alcohol dependence.

[140]  C. Thurstone,et al.  Medical marijuana diversion and associated problems in adolescent substance treatment. , 2011, Drug and alcohol dependence.

[141]  P. Shear,et al.  Ecstasy Exposure & Gender: Examining Components of Verbal Memory Functioning , 2014, PloS one.

[142]  H. J. Liang,et al.  Relationship between cognitive impairment and depressive symptoms in current ketamine users. , 2013, Journal of studies on alcohol and drugs.

[143]  John Scott,et al.  Variability in initial nicotine sensitivity due to sex, history of other drug use, and parental smoking. , 2009, Drug and alcohol dependence.

[144]  K. Cummings,et al.  Design and methods of the Population Assessment of Tobacco and Health (PATH) Study , 2016, Tobacco Control.

[145]  J. Temple,et al.  Effects of acute and chronic caffeine on risk-taking behavior in children and adolescents , 2017, Journal of psychopharmacology.

[146]  D A Dawson,et al.  Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. , 1997, Journal of substance abuse.

[147]  R. Corley,et al.  Medical marijuana use among adolescents in substance abuse treatment. , 2012, Journal of the American Academy of Child and Adolescent Psychiatry.

[148]  A. A. Scott,et al.  Adolescent inhalant use and executive cognitive functioning. , 2014, Child: care, health and development.

[149]  K. Corcoran,et al.  Ecstasy (MDMA) exposure and neuropsychological functioning: A polydrug perspective , 2005, Journal of the International Neuropsychological Society.

[150]  N. Pérez-Acevedo,et al.  Sex-specific effect of the anabolic steroid, 17α-methyltestosterone, on inhibitory avoidance learning in periadolescent rats , 2013, Behavioural Processes.

[151]  H. Mansvelder,et al.  Short- and long-term consequences of nicotine exposure during adolescence for prefrontal cortex neuronal network function. , 2012, Cold Spring Harbor Perspectives in Medicine.

[152]  Jennifer E. Merrill,et al.  Willingness to drink as a function of peer offers and peer norms in early adolescence. , 2014, Journal of studies on alcohol and drugs.

[153]  E. Groce The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research , 2018, Journal of Medical Regulation.

[154]  Rose A Rudd,et al.  Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015. , 2016, MMWR. Morbidity and mortality weekly report.

[155]  F. Crews,et al.  Mechanisms of neurodegeneration and regeneration in alcoholism. , 2009, Alcohol and alcoholism.

[156]  M. Bogenschutz It’s time to take psilocybin seriously as a possible treatment for substance use disorders , 2017, The American journal of drug and alcohol abuse.

[157]  Jordan M. Buck,et al.  The effects of adolescent methamphetamine exposure , 2015, Front. Neurosci..

[158]  W. Pelham,et al.  Childhood ADHD and adolescent substance use: an examination of deviant peer group affiliation as a risk factor. , 2003, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[159]  R. Schwartz Adolescent Abuse of Dextromethorphan , 2005, Clinical pediatrics.

[160]  M. J. Meloy,et al.  Brain development in heavy-drinking adolescents. , 2015, The American journal of psychiatry.

[161]  Jennifer L. Pearson,et al.  Indicators of dependence for different types of tobacco product users: Descriptive findings from Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) study. , 2017, Drug and alcohol dependence.

[162]  S. Mewaldt,et al.  Dose-response analysis of the behavioral effects of diazepam: I. Learning and memory , 2004, Psychopharmacology.

[163]  S. Tapert,et al.  Cannabis and alcohol use, and the developing brain , 2017, Behavioural Brain Research.

[164]  Thomas J. Dishion,et al.  The family check-up with high-risk young adolescents: Preventing early-onset substance use by parent monitoring , 2003 .

[165]  H. Cabral,et al.  Early adolescent executive functioning, intrauterine exposures and own drug use. , 2011, Neurotoxicology and teratology.

[166]  E. Gilpin,et al.  Determining the probability of future smoking among adolescents. , 2001, Addiction.

[167]  N. Martin,et al.  Do early experiences with cannabis vary in cigarette smokers? , 2013, Drug and alcohol dependence.

[168]  P. Rutigliano,et al.  The timeline followback reports of psychoactive substance use by drug-abusing patients: psychometric properties. , 2000, Journal of consulting and clinical psychology.

[169]  S. Tapert,et al.  Neural predictors of alcohol use and psychopathology symptoms in adolescents , 2016, Development and Psychopathology.

[170]  H. White,et al.  Towards the assessment of adolescent problem drinking. , 1989, Journal of studies on alcohol.

[171]  H. Fitzgerald,et al.  Parent, family, and neighborhood effects on the development of child substance use and other psychopathology from preschool to the start of adulthood. , 2009, Journal of studies on alcohol and drugs.

[172]  S. Tapert,et al.  Neuropsychological performance in adolescent marijuana users with co-occurring alcohol use: A three-year longitudinal study. , 2015, Neuropsychology.

[173]  M. Hallberg,et al.  Gamma-hydroxybutyrate (GHB) induces cognitive deficits and affects GABAB receptors and IGF-1 receptors in male rats , 2014, Behavioural Brain Research.

[174]  Linda Chang,et al.  Neuropsychological deficits in adolescent methamphetamine abusers , 2010, Psychopharmacology.

[175]  Adriana Galvan,et al.  The adolescent brain. , 2008, Developmental review : DR.

[176]  Z. Szabo,et al.  Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (±)3,4-methylenedioxymethamphetamine (“ecstasy”) users: relationship to cognitive performance , 2008, Psychopharmacology.

[177]  Gabriel I. Cook,et al.  Sex differences in the cognitive effects of tobacco abstinence: a pilot study. , 2012, Experimental and clinical psychopharmacology.

[178]  C. Hopfer,et al.  Implications of Marijuana Legalization for Adolescent Substance Use , 2014, Substance abuse.

[179]  P. Sham,et al.  Impulsivity, cognitive function, and their relationship in heroin-dependent individuals , 2013, Journal of clinical and experimental neuropsychology.

[180]  L. Sobell,et al.  Reliability of the Timeline Followback for cocaine, cannabis, and cigarette use. , 2014, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[181]  M. Schuckit,et al.  The relationships of the level of response to alcohol and additional characteristics to alcohol use disorders across adulthood: a discrete-time survival analysis. , 2009, Alcoholism, clinical and experimental research.

[182]  A. McKinney A review of the next day effects of alcohol on subjective mood ratings. , 2010, Current drug abuse reviews.

[183]  R. Poland,et al.  Pharmacokinetics of Hoasca alkaloids in healthy humans. , 1999, Journal of ethnopharmacology.

[184]  Timothy D. Ritchie,et al.  Developing and validating the "composite measure of problem behaviors". , 2011, Journal of clinical psychology.

[185]  S. Manson,et al.  Illicit Peyote Use Among American Indian Adolescents in Substance Abuse Treatment: A Preliminary Investigation , 2006, Substance use & misuse.

[186]  K. Bucholz,et al.  Initial reactions to tobacco and cannabis smoking: a twin study. , 2014, Addiction.

[187]  Alan Gevins,et al.  Neurocognitive effects of brivaracetam, levetiracetam, and lorazepam , 2010, Epilepsia.

[188]  B. J. Casey,et al.  Structural and functional brain development and its relation to cognitive development , 2000, Biological Psychology.

[189]  Liesbeth Reneman,et al.  Relationship between trait impulsivity and cortical volume, thickness and surface area in male cocaine users and non-drug using controls. , 2014, Drug and alcohol dependence.

[190]  R. Mahendran,et al.  Salvia divinorum: An overview of the usage, misuse, and addiction processes , 2016, Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists.

[191]  J. M. Miller,et al.  Exploring Butane Hash Oil Use: A Research Note , 2016, Journal of psychoactive drugs.

[192]  R. Griffiths,et al.  Inhaled vs. oral alprazolam: subjective, behavioral and cognitive effects, and modestly increased abuse potential , 2014, Psychopharmacology.

[193]  H. Curran,et al.  Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being , 2011, Psychological Medicine.

[194]  J. Temple,et al.  The Safety of Ingested Caffeine: A Comprehensive Review , 2017, Front. Psychiatry.

[195]  D. Cao,et al.  Characterization of edible marijuana product exposures reported to United States poison centers , 2016, Clinical toxicology.

[196]  L. Hyde,et al.  Adolescent dispositions for antisocial behavior in context: the roles of neighborhood dangerousness and parental knowledge. , 2009, Journal of abnormal psychology.

[197]  Jill Manit,et al.  National Survey on Drug Use and Health , 2009 .

[198]  K. Winters,et al.  Likelihood of developing an alcohol and cannabis use disorder during youth: association with recent use and age. , 2008, Drug and alcohol dependence.

[199]  L. Clark,et al.  Neural substrates of cognitive flexibility in cocaine and gambling addictions , 2015, British Journal of Psychiatry.

[200]  J. Suzuki,et al.  Hallucinogen Use Disorders. , 2016, Child and adolescent psychiatric clinics of North America.

[201]  C. Kahler,et al.  Development and validation of an adolescent smoking consequences questionnaire. , 2005, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[202]  M. Cohen-Zion,et al.  Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after a month of abstinence , 2007, Journal of the International Neuropsychological Society.

[203]  Timothy C. Durazzo,et al.  Alcohol Use Disorder with and without Stimulant Use: Brain Morphometry and Its Associations with Cigarette Smoking, Cognition, and Inhibitory Control , 2015, PloS one.

[204]  John E Donovan,et al.  Childhood risk factors for early-onset drinking. , 2011, Journal of studies on alcohol and drugs.

[205]  M. Rietschel,et al.  Neuropsychosocial profiles of current and future adolescent alcohol misusers , 2014, Nature.

[206]  Michael E Rybak,et al.  Caffeine intake in children in the United States and 10-y trends: 2001-2010. , 2014, The American journal of clinical nutrition.

[207]  Y. Kaminer,et al.  Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: a systematic review. , 2014, Addiction.

[208]  S. Shiffman,et al.  Validity of the hangover symptoms scale: evidence from an electronic diary study. , 2012, Alcoholism, clinical and experimental research.

[209]  Carles Soriano-Mas,et al.  Re‐appraisal of negative emotions in cocaine dependence: dysfunctional corticolimbic activation and connectivity , 2014, Addiction biology.

[210]  S. Brown,et al.  Marijuana and cocaine effect expectancies and drug use patterns. , 1991, Journal of consulting and clinical psychology.

[211]  Torsten Rohlfing,et al.  Influences of Age, Sex, and Moderate Alcohol Drinking on the Intrinsic Functional Architecture of Adolescent Brains , 2018, Cerebral cortex.

[212]  E. Grafstein,et al.  Frequent methamphetamine injection predicts emergency department utilization among street-involved youth. , 2012, Public health.

[213]  J. Donovan Really Underage Drinkers: The Epidemiology of Children’s Alcohol Use in the United States , 2007, Prevention Science.

[214]  S. Novak,et al.  Comparing Injection and Non-Injection Routes of Administration for Heroin, Methamphetamine, and Cocaine Users in the United States , 2011, Journal of addictive diseases.

[215]  Torsten Rohlfing,et al.  Cognitive, emotion control, and motor performance of adolescents in the NCANDA study: Contributions from alcohol consumption, age, sex, ethnicity, and family history of addiction. , 2016, Neuropsychology.

[216]  A. Mayer,et al.  Hyperactivation of the cognitive control network in cocaine use disorders during a multisensory Stroop task. , 2013, Drug and alcohol dependence.

[217]  Wieland Peschel Quality Control of Traditional Cannabis Tinctures: Pattern, Markers, and Stability , 2016, Scientia pharmaceutica.

[218]  C. Thurstone,et al.  Diversion of medical marijuana: when sharing is not a virtue. , 2013, Journal of the American Academy of Child and Adolescent Psychiatry.

[219]  P. Harrigan,et al.  Methamphetamine injecting is associated with phylogenetic clustering of hepatitis C virus infection among street-involved youth in Vancouver, Canada. , 2015, Drug and alcohol dependence.

[220]  J. Donovan Estimated Blood Alcohol Concentrations for Child and Adolescent Drinking and Their Implications for Screening Instruments , 2009, Pediatrics.

[221]  W. Liao,et al.  Comprehensive Application of Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club Drug-induced Cognitive Deficiency , 2015, Scientific Reports.

[222]  S. F. Feldstein Ewing,et al.  How Has Legal Recreational Cannabis Affected Adolescents in Your State? A Window of Opportunity. , 2017, American journal of public health.

[223]  I. Grant,et al.  Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure. , 2004, Drug and alcohol dependence.

[224]  Ying-wei Qiu,et al.  Potential gray matter unpruned in adolescents and young adults dependent on dextromethorphan-containing cough syrups: evidence from cortical and subcortical study , 2016, Brain Imaging and Behavior.

[225]  K. Kendler,et al.  A twin study of early cannabis use and subsequent use and abuse/dependence of other illicit drugs , 2004, Psychological Medicine.

[226]  P. Monti,et al.  Validity and Reliability of the Alcohol Expectancy Questionnaire-Adolescent, Brief , 2007, Journal of child & adolescent substance abuse.

[227]  Matthew W. Johnson,et al.  Hallucinogen use predicts reduced recidivism among substance-involved offenders under community corrections supervision , 2014, Journal of psychopharmacology.

[228]  P. Shear,et al.  Anxiety, depression, and behavioral symptoms of executive dysfunction in ecstasy users: contributions of polydrug use. , 2007, Drug and alcohol dependence.

[229]  S. Ennett,et al.  Attributes that Differentiate Children Who Sip Alcohol from Abstinent Peers , 2013, Journal of youth and adolescence.

[230]  P. Harris,et al.  Research electronic data capture (REDCap) - A metadata-driven methodology and workflow process for providing translational research informatics support , 2009, J. Biomed. Informatics.

[231]  K. Meador,et al.  Acute lorazepam effects on neurocognitive performance , 2012, Epilepsy & Behavior.

[232]  C. Pomerleau,et al.  Reliability of the Fagerstrom Tolerance Questionnaire and the Fagerstrom Test for Nicotine Dependence. , 1994, Addictive behaviors.

[233]  Suzanne M. Houston,et al.  The neurobiology of childhood structural brain development: conception through adulthood. , 2014, Current topics in behavioral neurosciences.

[234]  J. Nonnemaker,et al.  Initiation with menthol cigarettes and youth smoking uptake. , 2013, Addiction.

[235]  J. Hewitt,et al.  Common and drug-specific genetic influences on subjective effects to alcohol, tobacco and marijuana use. , 2011, Addiction.

[236]  M. Schuckit,et al.  The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects. , 2008, Alcohol and alcoholism.

[237]  Kosha Ruparel,et al.  Age‐related differences in working memory deficits during nicotine withdrawal , 2014, Addiction biology.

[238]  M Zloh,et al.  Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on delta9-THC and delta9-THC-acid. , 2008, Phytochemistry.

[239]  Laurence Steinberg,et al.  Peer influence on risk taking, risk preference, and risky decision making in adolescence and adulthood: an experimental study. , 2005, Developmental psychology.

[240]  T. Dishion,et al.  Intervening in Adolescent Problem Behavior: A Family-Centered Approach , 2003 .

[241]  A. A. Scott,et al.  An examination of information-processing skills among inhalant-using adolescents. , 2012, Child: care, health and development.

[242]  Joanna Jacobus,et al.  Altered white matter integrity in adolescent binge drinkers. , 2009, Alcoholism, clinical and experimental research.

[243]  Joanne N. Corbin Intervening in Adolescent Problem Behavior: A Family-Centered Approach , 2004 .

[244]  R. Murray,et al.  Daily use, especially of high-potency cannabis, drives the earlier onset of psychosis in cannabis users. , 2014, Schizophrenia bulletin.

[245]  K I Bolla,et al.  Differential effects of cocaine and cocaine alcohol on neurocognitive performance , 2000, Neurology.

[246]  C. Marczinski,et al.  Taurine, caffeine, and energy drinks: Reviewing the risks to the adolescent brain , 2017, Birth defects research.

[247]  Sarah W. Feldstein Ewing,et al.  Which matters most? Demographic, neuropsychological, personality, and situational factors in long-term marijuana and alcohol trajectories for justice-involved male youth. , 2015, Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors.

[248]  A. Scholey,et al.  Hair MDMA Samples Are Consistent with Reported Ecstasy Use: Findings from a Study Investigating Effects of Ecstasy on Mood and Memory , 2010, Neuropsychobiology.

[249]  Suzanne E. Welcome,et al.  Longitudinal Mapping of Cortical Thickness and Brain Growth in Normal Children , 2022 .

[250]  M. Bondi,et al.  Verbal learning and memory in alcohol abusers and polysubstance abusers with concurrent alcohol abuse , 1998, Journal of the International Neuropsychological Society.

[251]  B. Wexler,et al.  Brain Activity During Cocaine Craving and Gambling Urges: An fMRI Study , 2016, Neuropsychopharmacology.

[252]  Jagath C. Rajapakse,et al.  Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18 , 1996 .

[253]  P. Allen,et al.  Taking a first puff: cigarette smoking experiences among ethnically diverse adolescents. , 1999, Ethnicity & health.

[254]  R. Hallock,et al.  A survey of hallucinogenic mushroom use, factors related to usage, and perceptions of use among college students. , 2013, Drug and alcohol dependence.

[255]  Sheri J. Hartman,et al.  Predictive Validity of the Expanded Susceptibility to Smoke Index. , 2014, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[256]  S. Blakemore,et al.  The Developmental Mismatch in Structural Brain Maturation during Adolescence , 2014, Developmental Neuroscience.

[257]  D. Yurgelun-Todd,et al.  Psychological and Cognitive Effects of Long-Term Peyote Use Among Native Americans , 2005, Biological Psychiatry.

[258]  S. Gruber,et al.  Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. , 2011, Addiction.

[259]  B. Molina,et al.  Types of alcohol use experience from childhood through adolescence. , 2013, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[260]  F. Cantrell,et al.  Peyote and mescaline exposures: a 12-year review of a statewide poison center database , 2010, Clinical toxicology.

[261]  Brian A. King,et al.  Tobacco Use Among Middle and High School Students--United States, 2011-2015. , 2016, MMWR. Morbidity and mortality weekly report.

[262]  J L Collins,et al.  Youth risk behavior surveillance--United States, 1993. , 1995, The Journal of school health.

[263]  M. Gandal,et al.  Cannabis-induced psychosis associated with high potency “wax dabs” , 2016, Schizophrenia Research.

[264]  H. Geurts,et al.  Effects of methylphenidate on executive functioning in attention-deficit/hyperactivity disorder across the lifespan: a meta-regression analysis , 2016, Psychological Medicine.

[265]  Paola Dazzan,et al.  Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study. , 2015, The lancet. Psychiatry.