impaired proliferative capacity in acute and chronic SIVmac251 infection SIV-specific CD8+T-cells express high levels of PD1 and cytokines but have

[1]  M. Hoelscher,et al.  CD8 T-Cell Recognition of Multiple Epitopes within Specific Gag Regions Is Associated with Maintenance of a Low Steady-State Viremia in Human Immunodeficiency Virus Type 1-Seropositive Patients , 2006, Journal of Virology.

[2]  M. Lederman,et al.  Microbial translocation is a cause of systemic immune activation in chronic HIV infection , 2006, Nature Medicine.

[3]  J. Estaquier,et al.  Death of CD4+ T Cells from Lymph Nodes during Primary SIVmac251 Infection Predicts the Rate of AIDS Progression1 , 2006, The Journal of Immunology.

[4]  K. Okumura,et al.  B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts1 , 2006, The Journal of Immunology.

[5]  R. Balderas,et al.  Corrigendum: Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction , 2006, Nature Medicine.

[6]  R. Koup,et al.  PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection , 2006, The Journal of experimental medicine.

[7]  G. Freeman,et al.  Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade , 2006, The Journal of experimental medicine.

[8]  Todd M. Allen,et al.  HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1 , 2006, PLoS medicine.

[9]  Philip J. R. Goulder,et al.  PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression , 2006, Nature.

[10]  Brianne R. Barker,et al.  Virus-Specific Cellular Immune Correlates of Survival in Vaccinated Monkeys after Simian Immunodeficiency Virus Challenge , 2006, Journal of Virology.

[11]  R. Balderas,et al.  Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction , 2006, Nature Medicine.

[12]  Laurie Lamoreaux,et al.  Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry. , 2006, Journal of immunological methods.

[13]  Mario Roederer,et al.  HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. , 2006, Blood.

[14]  D. Montefiori,et al.  Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge , 2006, The Journal of experimental medicine.

[15]  P. Romero,et al.  Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation1 , 2006, The Journal of Immunology.

[16]  R. Ahmed,et al.  Restoring function in exhausted CD8 T cells during chronic viral infection , 2006, Nature.

[17]  C. Hellerbrand,et al.  PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis , 2006 .

[18]  Richard A Koup,et al.  T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. , 2004, Immunity.

[19]  E. Wherry,et al.  Antigen-independent memory CD8 T cells do not develop during chronic viral infection. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[20]  G. Freeman,et al.  PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. , 2004, Cellular immunology.

[21]  R. Koup,et al.  Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know , 2004, Nature Medicine.

[22]  Michael Cammer,et al.  Structural and functional analysis of the costimulatory receptor programmed death-1. , 2004, Immunity.

[23]  T. Reinhart,et al.  Productive infection of dendritic cells by simian immunodeficiency virus in macaque intestinal tissues , 2003, The Journal of pathology.

[24]  J. Estaquier,et al.  Caspase-dependent and -independent T-cell death pathways in pathogenic simian immunodeficiency virus infection: relationship to disease progression , 2003, Cell Death and Differentiation.

[25]  M. Gougeon,et al.  Cell death and immunity: Apoptosis as an HIV strategy to escape immune attack , 2003, Nature Reviews Immunology.

[26]  E. Wherry,et al.  Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment , 2003, Journal of Virology.

[27]  P. Marrack,et al.  Control of T cell viability. , 2003, Annual review of immunology.

[28]  R. Koup,et al.  Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. , 2003, Immunity.

[29]  D. Watkins,et al.  Emergence of cytotoxic T lymphocyte escape mutants following antiretroviral treatment suspension in rhesus macaques infected with SIVmac251. , 2003, Virology.

[30]  D. Montefiori,et al.  Vaccination of Macaques with Long-Standing SIVmac251 Infection Lowers the Viral Set Point After Cessation of Antiretroviral Therapy1 , 2002, The Journal of Immunology.

[31]  Haidong Dong,et al.  Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion , 2002, Nature Medicine.

[32]  Steven M. Wolinsky,et al.  Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes , 2002, Nature.

[33]  Todd M. Allen,et al.  Dominance of CD8 Responses Specific for Epitopes Bound by a Single Major Histocompatibility Complex Class I Molecule during the Acute Phase of Viral Infection , 2002, Journal of Virology.

[34]  J. Schmitz,et al.  Vaccine Protection Against Functional CTL Abnormalities in Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys1 , 2002, The Journal of Immunology.

[35]  D. Watkins,et al.  Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen , 2001, The Journal of Immunology.

[36]  J. Altman,et al.  Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells. , 2001, Immunity.

[37]  A. McMichael,et al.  Virus infections: escape, resistance, and counterattack. , 2001, Immunity.

[38]  Todd M. Allen,et al.  Impairment of Gag-Specific CD8+ T-Cell Function in Mucosal and Systemic Compartments of Simian Immunodeficiency Virus mac251- and Simian-Human Immunodeficiency Virus KU2-Infected Macaques , 2001, Journal of Virology.

[39]  N. Letvin,et al.  CD8+ cytotoxic T lymphocyte responses to lentiviruses and herpesviruses. , 2001, Current opinion in immunology.

[40]  S. Rowland-Jones,et al.  Cellular immune responses to HIV , 2001, Nature.

[41]  M. Ostrowski,et al.  Simian Immunodeficiency Virus (SIV) Infection of a Rhesus Macaque Induces SIV-Specific CD8+ T Cells with a Defect in Effector Function That Is Reversible on Extended Interleukin-2 Incubation , 2001, Journal of Virology.

[42]  Todd M. Allen,et al.  Functional Impairment of Simian Immunodeficiency Virus-Specific CD8+ T Cells during the Chronic Phase of Infection , 2001, Journal of Virology.

[43]  S. Rowland-Jones,et al.  Skewed maturation of memory HIV-specific CD8 T lymphocytes , 2001, Nature.

[44]  Alessandro Sette,et al.  Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia , 2000, Nature.

[45]  K. Metzner,et al.  Direct measurement of CD8+ T cell responses in macaques infected with simian immunodeficiency virus. , 2000, Virology.

[46]  Douglas D. Richman,et al.  HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function , 2000, The Journal of experimental medicine.

[47]  J. Schmitz,et al.  Emergence of CTL coincides with clearance of virus during primary simian immunodeficiency virus infection in rhesus monkeys. , 1999, Journal of immunology.

[48]  L. Weinberger,et al.  Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques , 1999, The Journal of experimental medicine.

[49]  D. Montefiori,et al.  Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. , 1999, Science.

[50]  S. Dandekar,et al.  Intestinal Intraepithelial Lymphocytes Are Primed for Gamma Interferon and MIP-1β Expression and Display Antiviral Cytotoxic Activity despite Severe CD4+ T-Cell Depletion in Primary Simian Immunodeficiency Virus Infection , 1998, Journal of Virology.

[51]  J. Sprent,et al.  Anti-viral immunity: Spotting virus-specific T cells , 1998, Current Biology.

[52]  Todd M. Allen,et al.  Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex , 1998, The Journal of experimental medicine.

[53]  R P Johnson,et al.  Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. , 1998, Science.

[54]  M A Nowak,et al.  Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. , 1998, Science.

[55]  T. Curiel,et al.  Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes , 1995, Nature Medicine.

[56]  G. Shaw,et al.  Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection , 1994, Journal of virology.

[57]  Rolf M. Zinkernagel,et al.  Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells , 1993, Nature.

[58]  T. Honjo,et al.  Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. , 1992, The EMBO journal.

[59]  J. Levy,et al.  CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. , 1986, Science.

[60]  G. Freeman,et al.  The B7 family revisited. , 2005, Annual review of immunology.

[61]  D. Venzon,et al.  Avipox-based simian immunodeficiency virus (SIV) vaccines elicit a high frequency of SIV-specific CD4+ and CD8+ T-cell responses in vaccinia-experienced SIVmac251-infected macaques. , 2004, Vaccine.