A TASTELESS DERIVATIVE OF CHLORAMPHENICOL

ALTHOUGH chloramphenicol has the advantage over both penicillin and streptomycin of being effective by mouth, this property is partly nullified by its extremely bitter taste. Recent work has shown, however, that certain derivatives of chloramphenicol, such as esters: and heterocyclic derivatives of the type (I)2, whilst retaining the antibiotic activity, no longer possess the bitter taste. It therefore appeared probable that cyclic esters such as the phosphite (11) would possess similar properties.