Topical application of 5‐aminolaevulinic acid, methyl 5‐aminolaevulinate and hexyl 5‐aminolaevulinate on normal human skin

Background  5‐Aminolaevulinic acid (ALA) and its ester derivatives are used in photodynamic therapy. Despite extensive investigations, the differences in biodistribution and pharmacokinetics of protoporphyrin IX (PpIX) induced by ALA and its derivatives are still not well understood, notably for humans.

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