Structure and Direction of Message in the Immune Network and Circuits

The major function of the immune system is the maintenance of macromolecular and cellular homeostasis in the body. Altered self and foreign macromolecules represent an aggressive challenge for the host because they have a tendency to alter the structure of messages which ensure the maintenance of homeostasis. The results of these alterations lead to the response against self-antigens (autoimmunity) or to foreign antigens (immune defense reactions).

[1]  C. Bona,et al.  Autoantibodies of various specificities encoded by genes from the VH J558 family bind to foreign antigens and share idiotopes of antibodies specific for self and foreign antigens , 1987, The Journal of experimental medicine.

[2]  J. Oudin,et al.  Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[3]  E. Sercarz,et al.  The Design of Regulatory Circuitry: Predominant Idiotypy and the Idea of Regulatory Parsimony a , 1983, Annals of the New York Academy of Sciences.

[4]  C. Bona,et al.  Immunochemical and molecular characterization of regulatory idiotopes expressed by monoclonal antibodies exhibiting or lacking beta 2-6 fructosan binding activity , 1985, The Journal of experimental medicine.

[5]  M. Steward.  Staphylococci and Staphylococcal Infections: Recent Progress , 1975 .

[6]  R. Cronkhite,et al.  A novel idiotopic determinant on phosphorylcholine-binding immunoglobulins restricted to isotype and allotype. , 1986, Journal of Immunology.

[7]  Umberto Eco,et al.  A theory of semiotics , 1976, Advances in semiotics.

[8]  S. Black,et al.  Regulatory circuits and antibody responses , 1980, European journal of immunology.

[9]  W. Paul,et al.  Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones , 1981, The Journal of experimental medicine.

[10]  J. Hiernaux,et al.  Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Jerne Nk.  Towards a network theory of the immune system. , 1974 .

[12]  C. Bona,et al.  Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[13]  R. Gershon.  T CELL REGULATION: THE “SECOND LAW OF THYMODYNAMICS” , 1974 .