Selective inhibition of BET bromodomains

[1]  Christopher B. Burge,et al.  c-Myc Regulates Transcriptional Pause Release , 2010, Cell.

[2]  Stephen V Frye,et al.  The art of the chemical probe. , 2010, Nature chemical biology.

[3]  A. Barabasi,et al.  Blueprint for antimicrobial hit discovery targeting metabolic networks , 2010, Proceedings of the National Academy of Sciences.

[4]  Tim J. Wigle,et al.  Screening for Inhibitors of Low-Affinity Epigenetic Peptide-Protein Interactions: An AlphaScreen™-Based Assay for Antagonists of Methyl-Lysine Binding Proteins , 2010, Journal of biomolecular screening.

[5]  C. Austin,et al.  A homogeneous method for investigation of methylation-dependent protein–protein interactions in epigenetics , 2009, Nucleic acids research.

[6]  K. Ozato,et al.  Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription. , 2009, Molecular biology of the cell.

[7]  M. Geyer,et al.  Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution* , 2009, The Journal of Biological Chemistry.

[8]  P. Howley,et al.  Regulation of Aurora B Expression by the Bromodomain Protein Brd4 , 2009, Molecular and Cellular Biology.

[9]  Tudor I. Oprea,et al.  A crowdsourcing evaluation of the NIH chemical probes. , 2009, Nature chemical biology.

[10]  M. Rubin,et al.  Diagnosis of NUT Midline Carcinoma Using a NUT-specific Monoclonal Antibody , 2009, The American journal of surgical pathology.

[11]  M. Ptashne.  Binding reactions: epigenetic switches, signal transduction and cancer , 2009, Current Biology.

[12]  Thomas S. Lin,et al.  Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia. , 2009, Blood.

[13]  C. Chiang,et al.  Faculty Opinions recommendation of Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. , 2009 .

[14]  Ming-Ming Zhou,et al.  Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA , 2008, Molecular and Cellular Biology.

[15]  P. Cole,et al.  Chemical probes for histone-modifying enzymes. , 2008, Nature chemical biology.

[16]  C. French.  Demystified molecular pathology of NUT midline carcinomas , 2008, Journal of Clinical Pathology.

[17]  J. Aster,et al.  BRD–NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells , 2008, Oncogene.

[18]  P. Anderson,et al.  Real-time and quantitative imaging of mammalian stress granules and processing bodies. , 2008, Methods in enzymology.

[19]  S. Knapp,et al.  A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases , 2007, Proceedings of the National Academy of Sciences.

[20]  Qiang Zhou,et al.  Brd4 Recruits P-TEFb to Chromosomes at Late Mitosis To Promote G1 Gene Expression and Cell Cycle Progression , 2007, Molecular and Cellular Biology.

[21]  Rodrigo Lopez,et al.  Clustal W and Clustal X version 2.0 , 2007, Bioinform..

[22]  F. Niesen,et al.  The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability , 2007, Nature Protocols.

[23]  M. Botchan,et al.  Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. , 2006, Molecular cell.

[24]  P. Howley,et al.  Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes , 2006, Journal of Virology.

[25]  Jay Painter,et al.  Electronic Reprint Biological Crystallography Optimal Description of a Protein Structure in Terms of Multiple Groups Undergoing Tls Motion Biological Crystallography Optimal Description of a Protein Structure in Terms of Multiple Groups Undergoing Tls Motion , 2005 .

[26]  S. Knapp,et al.  Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. , 2005, Journal of medicinal chemistry.

[27]  Qiang Zhou,et al.  Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. , 2005, Molecular cell.

[28]  Randy J Read,et al.  Electronic Reprint Biological Crystallography Likelihood-enhanced Fast Translation Functions Biological Crystallography Likelihood-enhanced Fast Translation Functions , 2022 .

[29]  Xiang-Jiao Yang,et al.  Multisite protein modification and intramolecular signaling , 2005, Oncogene.

[30]  Kevin Cowtan,et al.  research papers Acta Crystallographica Section D Biological , 2005 .

[31]  J. L. Hill,et al.  Translocation (11;15;19): a Highly Specific Chromosome Rearrangement Associated With Poorly Differentiated Thymic Carcinoma in Young Patients , 2003, American journal of clinical oncology.

[32]  J. Fletcher,et al.  BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. , 2003, Cancer research.

[33]  S. Schreiber,et al.  Signaling Network Model of Chromatin , 2002, Cell.

[34]  F. Collart,et al.  A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site. , 2002, Protein expression and purification.

[35]  Ming-Ming Zhou,et al.  Bromodomain: an acetyl‐lysine binding domain , 2002, FEBS letters.

[36]  J. Linden,et al.  2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors. , 2002, Journal of medicinal chemistry.

[37]  P. D. Dal Cin,et al.  BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). , 2001, The American journal of pathology.

[38]  C. Sawyers,et al.  Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. , 2001, The New England journal of medicine.

[39]  P. Evans,et al.  The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p , 2000, The EMBO journal.

[40]  P. Seeburg,et al.  Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. , 2000, Science.

[41]  J. Lippincott-Schwartz,et al.  A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G2-to-M Transition , 2000, Molecular and Cellular Biology.

[42]  Anastassis Perrakis,et al.  Automated protein model building combined with iterative structure refinement , 1999, Nature Structural Biology.

[43]  E. Buchdunger,et al.  In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. , 1999, Journal of the National Cancer Institute.

[44]  Zhongqi Zhang,et al.  A universal algorithm for fast and automated charge state deconvolution of electrospray mass-to-charge ratio spectra , 1998, Journal of the American Society for Mass Spectrometry.

[45]  J. Milton,et al.  Identification of multiple cyclin subunits of human P-TEFb. , 1998, Genes & development.

[46]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[47]  Z. Otwinowski,et al.  Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.

[48]  V. Walsh,et al.  The MRC Laboratory of Molecular Biology , 1997, Current Biology.

[49]  D. Price,et al.  Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase* , 1996, The Journal of Biological Chemistry.

[50]  Jürg Zimmermann,et al.  Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells , 1996, Nature Medicine.

[51]  T. Meyer,et al.  Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. , 1996, Cancer research.

[52]  D. Price,et al.  Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation (*) , 1995, The Journal of Biological Chemistry.

[53]  N. Lydon,et al.  Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[54]  M. O'Donnell,et al.  Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor. , 1991, Journal of medicinal chemistry.

[55]  U. Kees,et al.  Intrathoracic carcinoma in an 11-year-old girl showing a translocation t(15;19). , 1991, The American journal of pediatric hematology/oncology.

[56]  J F Brandts,et al.  Rapid measurement of binding constants and heats of binding using a new titration calorimeter. , 1989, Analytical biochemistry.

[57]  Zhen-yi Wang,et al.  Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. , 1988, Haematology and blood transfusion.

[58]  P. Vonvoigtlander,et al.  Alprazolam: Review of pharmacological, pharmacokinetic, and clinical data , 1985 .

[59]  K. Marushige.  Activation of chromatin by acetylation of histone side chains. , 1976, Proceedings of the National Academy of Sciences of the United States of America.